Results 41 to 50 of about 24,108,879 (155)

Table_1_Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans.xlsx

, 2021
Selenoprotein P is a hepatokine with antioxidative properties that eliminate a physiologic burst of reactive oxygen species required for intracellular signal transduction.
Yuki Isobe (2898251), Hiroyuki Nakamura (200082), Takehiro Kanamori (8255321), Hiromasa Tsujiguchi (4258522), Atsushi Tajima (40311), Akinori Hara (452250), Takayuki Kannon (10175561), Yumie Takeshita (307060), Hiroki Asakura (4258519), Toshinari Takamura (158655), Kiyo-aki Ishii (10175564), Tatsuya Yamashita (3067323), Shuichi Kaneko (156576), Hiroaki Takayama (2530507)   +13 more
core   +1 more source

Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models

Nature Communications, 2017
Selenoprotein P is secreted by the liver and when present in excess it promotes development of type 2 diabetes. Here the authors develop neutralizing antibodies to target human and mouse selenoprotein P, and show that they improve insulin secretion and ...
Yuichiro Mita, Kaho Nakayama, Shogo Inari, Yukina Nishito, Yuya Yoshioka, Naoko Sakai, Kanade Sotani, Takahiro Nagamura, Yuki Kuzuhara, Kumi Inagaki, Miki Iwasaki, Hirofumi Misu, Masaya Ikegawa, Toshinari Takamura, Noriko Noguchi, Yoshiro Saito   +15 more
doaj   +1 more source

Evolution of selenoproteins in the metazoan

BMC Genomics, 2012
Background The selenocysteine (Sec) containing proteins, selenoproteins, are an important group of proteins present throughout all 3 kingdoms of life.
Jiang Liang, Ni Jiazuan, Liu Qiong
doaj   +1 more source

Relationship between Selenium and Hematological Markers in Young Adults with Normal Weight or Overweight/Obesity

Antioxidants, 2019
Selenium deficiency has been linked to anemia of inflammation, which is mediated by hepcidin. However, there are few studies providing evidence of the role of hepcidin in this relationship.
Doreen Yvonne Larvie, Jeanne Lynn Doherty, George L. Donati, Seth Mensah Armah   +3 more
doaj   +1 more source

Carrier‐Free Berberine/Nitidine Chloride Self‐Assembled Nanoparticles Induce Ferroptosis to Overcome Bortezomib Resistance in Multiple Myeloma

Advanced Science, EarlyView.
A schematic illustrating the fabrication process and ferroptosis‐mediated therapeutic mechanism of carrier‐free self‐assembled BBR/NC‐SAPs for overcoming bortezomib resistance in multiple myeloma. ABSTRACT Therapeutic relapse driven by bortezomib resistance represents a formidable clinical barrier in the management of multiple myeloma (MM).
Yiwen Lv, Shuang Liu, Hong Wu, Guiluan Li, Ying Rong, Guangchao Li, Yangmin Zhu, Qi Zhong, Ruiming Ou, Huijuan Shen, Zhi Liu, Jing Huang, Zhenwei Wang, Pei Lin, Qing Zhang, Guopan Yu, Zhao Yin   +16 more
wiley   +1 more source

Association of Selenoprotein P Levels With Proteinuria Severity in Newly Diagnosed Type 2 Diabetes Mellitus

Selçuk Tıp Dergisi
Objective: Diabetic nephropathy is one of the leading causes of chronic kidney disease and progression to end-stage renal failure. Identifying new biomarkers that correlate with nephropathy severity may improve risk stratification and clinical
Mustafa Turgut Yildizgoren, MEVLÜT HAKAN GÖKTEPE, Adem Ay, Gürkan Yarbas, Bilal Ilanbey, Cahit Uçar   +5 more
doaj   +1 more source

Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity

Advanced Science, EarlyView.
Se‐Ssp was engineered as a potent immunomodulator for activating innate immunity via the TLR and cGAS‐STING pathways, therefore converting “cold” tumors into “hot” tumors to achieve high efficacy and long‐term therapeutic outcomes. ABSTRACT Immunotherapy has shed light on clinical oncology for several decades.
Yuqi Yang, Xiaowei Cai, Xiaoyan Zhong, Tian Qiu, Qinwei Lu, Jiahao Qin, Fei Gong, Yecheng Huang, Chenyu Jiang, Youdong Chen, Yuan Cheng, Liang Cheng   +11 more
wiley   +1 more source

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

Selenium influences tissue levels of selenoprotein W in sheep. [PDF]

, 2010
[[abstract]]Because selenium increases the levels of other selenoproteins, the influence of this element on selenoprotein W was examined in wether sheep fed either a low selenium diet (0.02 mg/kg) or the same diet supplemented with 3 mg selenium as ...
Yeh, J. Y.;Gu, Q.;Beilstein, M. A.;Forsberg, N. E.;Whanger, P. D
core  

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source