Evidence of epistasis between Interleukin-1 and Selenoprotein-S with susceptibility to rheumatoid arthritis [PDF]
, 2009 Objective: Selenoprotein-S (SELS) is involved in the stress response within the endoplasmic reticulum (ER) and inflammation. Recently, promoter variants in the SELS gene were shown to be associated with plasma levels of interleukin (IL)6, IL1β and tumour
Binks, M.H. +5 more
core +2 more sources
Localization and regulation of pancreatic selenoprotein P [PDF]
Journal of Molecular Endocrinology, 2012 Progressive loss of pancreatic β-cell mass is a crucial feature of type 2 diabetes mellitus. As β-cells express very low amounts of the antioxidant enzymes catalase and glutathione peroxidase (GPx), they appear to be particularly vulnerable to oxidative damage in the pathogenesis of diabetes.
Holger, Steinbrenner +8 more
openaire +2 more sources
Paradoxical roles of antioxidant enzymes:Basic mechanisms and health implications [PDF]
, 2015 Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from aerobic metabolism, as a result of accidental electron leakage as well as regulated enzymatic processes.
Amit R. Reddi +38 more
core +1 more source
Role of microRNA-7 and selenoprotein P in hepatocellular carcinoma
Tumor Biology, 2017 There is an obvious need to diagnose hepatocellular carcinoma using novel non-invasive and sensitive biomarkers. In this regard, the aim of this study was to evaluate and correlate both relative quantification of microRNA-7 using quantitative real time ...
Marwa Tarek +5 more
doaj +1 more source
Selenium supplementation for the primary prevention of cardiovascular disease [PDF]
, 2013 Background: Selenium is a key component of a number of selenoproteins which protect against oxidative stress and have the potential to prevent chronic diseases including cardiovascular disease (CVD).
Clarke, Aileen +5 more
core +1 more source
Molecular mechanism of selenoprotein P synthesis
Biochimica et Biophysica Acta (BBA) - General Subjects, 2018 Selenoprotein synthesis requires the reinterpretation of a UGA stop codon as one that encodes selenocysteine (Sec), a process that requires a set of dedicated translation factors. Among the mammalian selenoproteins, Selenoprotein P (SELENOP) is unique as it contains a selenocysteine-rich domain that requires multiple Sec incorporation events.In this ...
Sumangala, Shetty, Paul R, Copeland
openaire +3 more sources
Mercury and selenium binding biomolecules in terrestrial mammals (Cervus elaphus and Sus scrofa) from a mercury exposed area [PDF]
, 2017 Acknowledgements The authors are grateful to Junta de Comunidades de Castilla-La Mancha (PCC-05-004-2, PAI06-0094, PCI-08-0096, PEII09-0032-5329) and the Ministerio de Economía y Competitividad (CTQ2013-48411-P) for financial support. M.J.
Fariñas, N. Rodríguez +5 more
core +1 more source
Poultry Science, 2022 : This study's objective was to investigate the effects of dietary Se (in the form of selenomethionine) on the antioxidant activity and selenoprotein gene expressions in layer breeder roosters.
Cheng Long +10 more
doaj +1 more source
Impact of treatment planning target volumen (PTV) size on radiation induced diarrhoea following selenium supplementation in gynecologic radiation oncology - a subgroup analysis of a multicenter, phase III trial [PDF]
, 2013 Background: In a previous analysis (Int J Radiat Oncol Biol Phys 70:828-835,2010), we assessed whether an adjuvant supplementation with selenium (Se) improves Se status and reduces the radiation-induced side-effects of patients treated by adjuvant ...
Adamietz, Irenäus A. +14 more
core +1 more source
Selenoprotein Metabolism and Function: Evidence for More than One Function for Selenoprotein P [PDF]
The Journal of Nutrition, 2003 Biological functions of selenium are exerted by selenoproteins that contain selenocysteine in their primary structure. Selenocysteine is synthesized and inserted into proteins cotranslationally by a complex process. Families of selenoproteins include the glutathione peroxidases, the iodothyronine deiodinases and the thioredoxin reductases.
Raymond F, Burk +2 more
openaire +2 more sources