Results 71 to 80 of about 17,575 (209)

Selenium‐Based Nanoplatforms: An Emerging Theranostic Paradigm for Gynecological Cancers

Advanced Science, EarlyView.
This reivew summarizes Selenium as a multifunctional anticancer regulator in gynecological cancers. It reduces tumor risk, enhances therapeutic efficacy, and reduces treatment toxicity. Selenium also overcomes chemoraditherapy resistance, improving overall treatment outcomes. ABSTRACT Gynecological cancers present significant therapeutic challenges due
Hejing Liu, Yujia Zhou, Zihan Zhang, Rong Ma, Luyi Ruan, Liqing Miao, Boxin Zhang, Huihui Ji, Tianfeng Chen, Xueqiong Zhu   +9 more
wiley   +1 more source

Multi‐omics data mining combined with experimental validation reveals ferroptosis‐ and autophagy‐associated hub genes as diagnostic candidates and immune modulators in atherosclerosis

Animal Models and Experimental Medicine, EarlyView.
Using the GSE225650 dataset, we performed differential expression gene (DEG) screening, Weighted Gene Coexpression Network Analysis (WGCNA), and immune infiltration profiling on atherosclerosis (AS) samples, yielding 104 shared candidate genes. Subsequently, these 104 candidate genes were intersected with ferroptosis‑ and autophagy‑related gene sets ...
Xinou Zheng, Jinling Zheng, Xuezhuang Li, Hua Chen, Li Zhang, Yuqiong Zhao, Yahao Ling   +6 more
wiley   +1 more source

Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis [PDF]

, 2016
Selenium, an essential micronutrient known for its cancer prevention properties, is incorporated into a class of selenocysteine-containing proteins (selenoproteins).
Asara, John M., Brown, Kristin K., Chang, Christopher J., Chhangawala, Sagar, Cox, Andrew G., Dickinson, Bryan, Evason, Kimberley J., Gladyshev, Vadim N., Goessling, Wolfram, Heidel, Jerry, Houvras, Yariv, Hwang, Katie L., Kim, Andrew J., Lee, Byung Cheon, Lien, Evan C., Nissim, Sahar, Saunders, Diane, Tsomides, Allison, Yuan, Min   +18 more
core   +1 more source

Pancreatic atrophy caused by dietary selenium deficiency induces hypoinsulinemic hyperglycemia via global down-regulation of selenoprotein encoding genes in broilers. [PDF]

PLoS ONE, 2017
This study was envisaged to comprehensively profile genes in selected tissues along with a few biochemical indicators and integrate resulting information with dietary selenium (Se) deficiency symptoms in broilers.
Jingyang Xu, Longqiong Wang, Jiayong Tang, Gang Jia, Guangmang Liu, Xiaoling Chen, Jingyi Cai, Haiying Shang, Hua Zhao   +8 more
doaj   +1 more source

Selenomethionine Regulates the Arachidonic Acid Metabolism‐Ferroptosis‐Inflammation Axis to Ameliorate Colitis

Animal Research and One Health, EarlyView.
Selenomethionine can ameliorate arachidonic acid‐induced colonic injury through synergistic mechanisms, including alleviating inflammatory responses, improving barrier integrity, enhancing antioxidant capacity by upregulating selenoprotein expression, selectively regulating AA metabolism to reduce pro‐inflammatory oxylipins and promote the production ...
Huihui Tian, Longzhu Zhou, Xiaohui Feng, Jialu Shen, Xiaoping Du, Qingyu Zhao, Yuchang Qin, Junmin Zhang, Chaohua Tang   +8 more
wiley   +1 more source

Sex-specific and inter-individual differences in biomarkers of selenium status identified by a calibrated ELISA for selenoprotein P [PDF]

, 2017
Selenoprotein P (SELENOP) is a liver-derived transporter of selenium (Se) in blood, and a meaningful biomarker of Se status. Se is an essential trace element for the biosynthesis of enzymatically-active selenoproteins, protecting the organism from ...
Hybsier, Sandra, Schulz, Torsten, Wu, Zida, Demuth, Ilja, Minich, Waldemar B., Renko, Kostja, Rijntjes, Eddy, Köhrle, Josef, Strasburger, Christian J., Steinhagen-Thiessen, Elisabeth, Schomburg, Lutz   +10 more
core   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Systemic adipokines, hepatokines and interleukin-6 in HCV-monoinfected and HCV/HIV coinfected patients treated with direct antiviral agents (DAAs) [PDF]

, 2018
In this study, we demonstrated that that altered levels ofadipokines/hepatokines in HCV-infected patients, including HIV coinfected, can be restored by treatment with direct antiviral agents (DAAs), thus indicating the important metabolic changes ...
Alfieri, Giulia, Corano-Scheri, Giuseppe, D'Ettorre, Gabriella, Fard, Saeid Najafi, Lichtner, Miriam, Mascia, Claudia, Mastroianni, Claudio Maria, Pavone, Paolo, Pinacchio, Claudia, Tieghi, Tiziana, Vullo, Vincenzo   +10 more
core   +1 more source

Role of selenium in the pathophysiology of cardiorenal anaemia syndrome

ESC Heart Failure, Volume 12, Issue 2, Page 770-780, April 2025.
Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)].
Shigeyuki Arai, Minoru Yasukawa, Shigeru Shibata   +2 more
wiley   +1 more source

Uptake and Utilization of Selenium from Selenoprotein P [PDF]

Biological Trace Element Research, 2017
Selenoprotein P (SELENOP) is a serum glycoprotein that is required for proper selenium distribution in mammals, particularly in supplying selenium to the brain and testes. As the sole mechanism for providing essential selenium to developing spermatozoa, SELENOP metabolism is central to male fertility in all mammals.
Sumangala Shetty, John R. Marsicano, Paul R. Copeland   +2 more
openaire   +2 more sources