Results 51 to 60 of about 14,403 (240)
A Method for Identification of Selenoprotein Genes in Archaeal Genomes [PDF]
, 2009 The genetic codon UGA has a dual function: serving as a terminator and encoding selenocysteine. However, most popular gene annotation programs only take it as a stop signal, resulting in misannotation or completely missing selenoprotein genes.
Yanzhao Huang +5 more
core +1 more source
Table_1_Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans.docx [PDF]
, 2021 Selenoprotein P is a hepatokine with antioxidative properties that eliminate a physiologic burst of reactive oxygen species required for intracellular signal transduction.
Yuki Isobe (2898251) +13 more
core +1 more source
A Crystalline and Thermally Stable Selenocysteine Selenenic Acid
Angewandte Chemie International Edition, EarlyView.The long‐sought catalytic intermediate of selenoproteins, selenocysteine selenenic acid (Sec–SeOH), is isolated for the first time at ambient temperature. A bioinspired selenopeptide sequence encapsulated within a protective molecular cradle and an oxidant‐free route from selenenyl iodide (Sec–SeI) enable the isolation of Sec–SeOH. Contrary to the long‐
Ryosuke Masuda, Satoru Kuwano, Kei Goto
wiley +1 more source
SEP15 (15 kDa selenoprotein) [PDF]
, 2011 Review on SEP15 (15 kDa selenoprotein), with data on DNA, on the protein encoded, and where the gene is ...
E Reszka +7 more
core +1 more source
The Effect of tRNA[Ser]Sec Isopentenylation on Selenoprotein Expression [PDF]
, 2021 Transfer RNA[Ser]Sec carries multiple post-transcriptional modifications. The A37G mutation in tRNA[Ser]Sec abrogates isopentenylation of base 37 and has a profound effect on selenoprotein expression in mice. Patients with a homozygous pathogenic p.R323Q
Wenchao Zhao +13 more
core +1 more source
Animal Research and One Health, EarlyView.Selenomethionine can ameliorate arachidonic acid‐induced colonic injury through synergistic mechanisms, including alleviating inflammatory responses, improving barrier integrity, enhancing antioxidant capacity by upregulating selenoprotein expression, selectively regulating AA metabolism to reduce pro‐inflammatory oxylipins and promote the production ...
Huihui Tian +8 more
wiley +1 more source
Evolution of selenoproteins in the metazoan [PDF]
BMC Genomics, 2012 Abstract Background The selenocysteine (Sec) containing proteins, selenoproteins, are an important group of proteins present throughout all 3 kingdoms of life. With the rapid progression of selenoprotein research in the post-genomic era, application of bioinformatics methods to the identification of selenoproteins in ...
Jiang Liang, Ni Jiazuan, Liu Qiong
openaire +3 more sources
Activation of the selenoprotein SEPS1 gene expression by pro-inflammatory cytokines in HepG2 cells [PDF]
, 2006 SEPS1 (also called selenoprotein S, SelS) plays an important role in the production of inflammatory cytokines and its expression is activated by endoplasmic reticulum (ER) stress.
Gao, Yuan +9 more
core +1 more source
Cells, 2019 The translation of selenoprotein mRNAs involves a non-canonical ribosomal event in which an in-frame UGA is recoded as a selenocysteine (Sec) codon instead of being read as a stop codon.
Caroline Vindry +4 more
doaj +1 more source
Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy
BMEMat, EarlyView.Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu +5 more
wiley +1 more source