Results 71 to 80 of about 14,403 (240)

Role of selenium in the pathophysiology of cardiorenal anaemia syndrome

ESC Heart Failure, Volume 12, Issue 2, Page 770-780, April 2025.
Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)].
Shigeyuki Arai, Minoru Yasukawa, Shigeru Shibata   +2 more
wiley   +1 more source

Modification of Selenoprotein mRNAs by Cap Tri-methylation [PDF]

, 2017
Several selenoprotein mRNAs undergo 5' cap maturation events whereby their classical monomethylated m(7)G cap becomes trimethylated (m3(2,2,7)G) by the trimethylguanosine synthase 1 (Tgs1).
Gribling-Burrer, Anne-Sophie, Anne-Sophie Gribling-Burrer, Allmang-Cura, Christine, Eriani, Gilbert, Christine Allmang, Gilbert Eriani   +5 more
core   +1 more source

Computational identification of the selenocysteine tRNA (tRNASec) in genomes. [PDF]

PLoS Computational Biology, 2017
Selenocysteine (Sec) is known as the 21st amino acid, a cysteine analogue with selenium replacing sulphur. Sec is inserted co-translationally in a small fraction of proteins called selenoproteins.
Didac Santesmasses, Marco Mariotti, Roderic Guigó   +2 more
doaj   +1 more source

The Role of Selenoprotein Tissue Homeostasis in MetS Programming: Energy Balance and Cardiometabolic Implications

Antioxidants, 2022
Selenium (Se) is an essential trace element mainly known for its antioxidant, anti-inflammatory, and anti-apoptotic properties, as it is part of the catalytic center of 25 different selenoproteins.
María Luisa Ojeda, Olimpia Carreras, Fátima Nogales   +2 more
doaj   +1 more source

deep-Sep: a deep learning-based method for fast and accurate prediction of selenoprotein genes in bacteria

mSystems
Selenoproteins are a special group of proteins with major roles in cellular antioxidant defense. They contain the 21st amino acid selenocysteine (Sec) in the active sites, which is encoded by an in-frame UGA codon.
Yao Xiao, Yan Zhang
doaj   +1 more source

Disruption of Selenium Handling During Puberty Causes Sex-Specific Neurological Impairments in Mice

Antioxidants, 2019
Selenium is an essential trace element linked to normal development and antioxidant defense mechanisms through its incorporation into selenoproteins via the amino acid, selenocysteine (Sec).
Penny M. Kremer, Daniel J. Torres, Ann C. Hashimoto, Marla J. Berry   +3 more
doaj   +1 more source

Activation of Nrf2 by Electrophiles Is Largely Independent of the Selenium Status of HepG2 Cells

Antioxidants, 2021
Selenoenzymes, whose activity depends on adequate selenium (Se) supply, and phase II enzymes, encoded by target genes of nuclear factor erythroid 2-related factor 2 (Nrf2), take part in governing cellular redox homeostasis.
Sarah Tauber, Maria Katharina Sieckmann, Katrin Erler, Wilhelm Stahl, Lars-Oliver Klotz, Holger Steinbrenner   +5 more
doaj   +1 more source

Nucleophile Exchange Mechanistic Paths in Chalcogenolate‐Dichalcogenide Systems: Insight From Computational Chemistry

European Journal of Organic Chemistry, EarlyView.
The change of the chalcogen! This computational study explores trends in Group 16 nucleophile exchange model reactions, providing mechanistic insight in gas phase and in solvent as well as biological implications, which can guide the design of improved biomimetic catalysts.
Alessandro Rubbi, Andrea Trovato, Laura Orian   +2 more
wiley   +1 more source

Relative tissue expression of selenoprotein transcripts. [PDF]

, 2015
Relative transcript expression was determined by RTPCR relative to the level of selenoprotein transcript in the liver, as described in the text, in triplicate. The primer pairs used for these analyses are shown in Table 3.
Colin M. Sunde (754050), Milton L. Sunde (754051), Roger A. Sunde (442285), Jacqueline K. Evenson (754052), Gavin R. Sunde (754049)   +4 more
core   +1 more source

Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models

Nature Communications, 2017
Selenoprotein P is secreted by the liver and when present in excess it promotes development of type 2 diabetes. Here the authors develop neutralizing antibodies to target human and mouse selenoprotein P, and show that they improve insulin secretion and ...
Yuichiro Mita, Kaho Nakayama, Shogo Inari, Yukina Nishito, Yuya Yoshioka, Naoko Sakai, Kanade Sotani, Takahiro Nagamura, Yuki Kuzuhara, Kumi Inagaki, Miki Iwasaki, Hirofumi Misu, Masaya Ikegawa, Toshinari Takamura, Noriko Noguchi, Yoshiro Saito   +15 more
doaj   +1 more source