Results 31 to 40 of about 14,403 (240)

Selenoprotein P concentrations and risk of progression from mild cognitive impairment to dementia

Scientific Reports, 2023
There is a growing literature investigating the effects of selenium on the central nervous system and cognitive function. However, little is known about the role of selenoprotein P, the main selenium transporter, which can also have adverse biological ...
Marco Vinceti, Teresa Urbano, Annalisa Chiari, Tommaso Filippini, Lauren A. Wise, Manuela Tondelli, Bernhard Michalke, Misaki Shimizu, Yoshiro Saito   +8 more
doaj   +1 more source

Selenoprotein Gene Nomenclature [PDF]

, 2019
The human genome contains 25 genes coding for selenocysteine-containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis.
Driscoll, Donna, Hatfield, Dolph, Hesketh, John, Diamond, Alan, Burk, Raymond, Schweizer, Ulrich, Gladyshev, Vadim, Simonović, Miljan, Rayman, Margaret, Zhang, Yan, Kim, Hwa-Young, Prabhu, K. Sandeep, Ursini, Fulvio, Conrad, Marcus, Carlson, Bradley, Copeland, Paul, Berry, Marla, Lescure, Alain, Mariotti, Marco, Sunde, Roger, Huang, Kaixun, Bruford, Elspeth, Holmgren, Arne, Lobanov, Alexei, Ferreiro, Ana, Loscalzo, Joseph, Arnér, Elias S., Brigelius-Flohé, Regina, Maiorino, Matilde, Castellano, Sergi, Lei, Xin Gen, Howard, Michael, Whanger, Philip, Salinas, Gustavo, Krol, Alain, Köhrle, Josef, Schomburg, Lutz, Liu, Qiong, Lee, Byung Cheon, Hondal, Robert, Lee, Byeong Jae, Tweedie, Susan, Hoffmann, Peter, Chavatte, Laurent, Handy, Diane, Kim, Ick Young, Tsuji, Petra, Schmidt, Edward, Guigó, Roderic, Flohé, Leopold, Kryukov, Gregory, Green, Fiona, Rozovsky, Sharon   +52 more
core   +1 more source

Selenium and selenoprotein deficiencies induce widespread pyogranuloma formation in mice, while high levels of dietary selenium decrease liver tumor size driven by TGFα.

PLoS ONE, 2013
Changes in dietary selenium and selenoprotein status may influence both anti- and pro-cancer pathways, making the outcome of interventions different from one study to another.
Mohamed E Moustafa, Bradley A Carlson, Miriam R Anver, Gerd Bobe, Nianxin Zhong, Jerrold M Ward, Christine M Perella, Victoria J Hoffmann, Keith Rogers, Gerald F Combs, Ulrich Schweizer, Glenn Merlino, Vadim N Gladyshev, Dolph L Hatfield   +13 more
doaj   +1 more source

Selenoproteins and their emerging roles in signaling pathways

Regulatory Mechanisms in Biosystems, 2020
The functional activity of selenoproteins has a wide range of effects on complex pathogenetic processes, including teratogenesis, immuno-inflammatory, neurodegenerative.
N. V. Stanishevska
doaj   +1 more source

Beyond antioxidants: Selenium and skeletal muscle mitochondria

Frontiers in Veterinary Science, 2022
The element, Selenium (Se), has an essential nutritive and biological role as a trace mineral known primarily for its vital antioxidant functions as a constituent of the selenoenzyme, glutathione peroxidase.
Lauren T. Wesolowski, Pier L. Semanchik, Sarah H. White-Springer   +2 more
doaj   +1 more source

A randomized trial of selenium supplementation and risk of type-2 diabetes, as assessed by plasma adiponectin [PDF]

, 2012
Background: Evidence that selenium affects the risk of type-2 diabetes is conflicting, with observational studies and a few randomized trials showing both lower and higher risk linked to the level of selenium intake and status. We investigated the effect
Steinbrenner, Holger, Eliseo Guallar, Roberto Pastor-Barriuso, Stranges, S, Steinbrenner Holger, Blundell-Pound, G, Eliseo Guallar (27363), Gabrielle Blundell-Pound, Pastor-Barriuso, R, Margaret P Rayman, Pastor-Barriuso, Roberto, Blundell-Pound Gabrielle, Rayman, Margaret, Blundell-Pound, Gabrielle, Holger Steinbrenner, Stranges, Saverio, Roberto Pastor-Barriuso (62759), Gabrielle Blundell-Pound (135140), Stranges Saverio, Guallar, E, Guallar, Eliseo, Saverio Stranges, Rayman, Margaret P, Pastor-Barriuso, R., Holger Steinbrenner (135147), Steinbrenner, H, Rayman, MP, Saverio Stranges (73786), Pastor-Barriuso Roberto, Margaret P. Rayman (135136), Rayman Margaret P., Guallar Eliseo   +31 more
core   +1 more source

Roles of Selenoproteins in Brain Function and the Potential Mechanism of Selenium in Alzheimer’s Disease

Frontiers in Neuroscience, 2021
Selenium (Se) and its compounds have been reported to have great potential in the prevention and treatment of Alzheimer’s disease (AD). However, little is known about the functional mechanism of Se in these processes, limiting its further clinical ...
Zhong-Hao Zhang, Zhong-Hao Zhang, Guo-Li Song, Guo-Li Song, Guo-Li Song   +4 more
doaj   +1 more source

Selenium in Prostate Cancer: Prevention, Progression, and Treatment

Pharmaceuticals, 2023
Selenium, a trace mineral with various biological functions, has become a focal point in prostate cancer research. This review aims to present a comprehensive overview of selenium’s involvement in prostate cancer, covering its impact on prevention ...
Jinjiang Jiang, Bo Chen, Bo Tang, Qiang Wei   +3 more
doaj   +1 more source

Selenoprotein P levels in patients with diabetes mellitus with complications [PDF]

, 2022
Aims: Increasing evidence has shown that selenoprotein P levels are elevated in type 2 diabetes mellitus and are associated with insulin resistance and release.
Yücel, Hasan Esat, Ilanbey, Bilal, Kocamış, Özkan, Uçar, Cahit   +3 more
core   +1 more source

Hydroxy-Selenomethionine Improves the Selenium Status and Helps to Maintain Broiler Performances under a High Stocking Density and Heat Stress Conditions through a Better Redox and Immune Response

Antioxidants, 2021
This study has determined whether hydroxy-selenomethionine (OH-SeMet) exerts a better protective action on broilers against environmental stress than sodium selenite (SS) or seleno-yeast (SY).
Hua Sun, Ling Zhao, Zi-Jian Xu, Michele De Marco, Mickael Briens, Xiang-Hua Yan, Lv-Hui Sun   +6 more
doaj   +1 more source