Results 11 to 20 of about 12,163 (193)
Journal of Biological Chemistry, 2009 Selenium is an essential micronutrient for man and animals. The role of selenium has been attributed largely to its presence in selenoproteins as the 21st amino acid, selenocysteine (Sec, U). Sec is encoded by TGA in DNA. A unique mechanism is used to decode the UGA codon in mRNA to co-translationally incorporate Sec into the growing polypeptide ...
Jun, Lu, Arne, Holmgren
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Molecules, 2023 Selenium (Se) is a naturally occurring essential micronutrient that is required for human health. The existing form of Se includes inorganic and organic. In contrast to the inorganic Se, which has low bioavailability and high cytotoxicity, organic Se exhibits higher bioavailability, lower toxicity, and has a more diverse composition and structure. This
Ziqi Qi, Alex Duan, Ken Ng
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Frontiers in Animal Science, 2022 Many supplemental Se-dependent metabolic effects are mediated through the function of selenoproteins. The full complement and relative abundance of selenoproteins expressed by highly metabolic cattle tissues have not been characterized in cattle.
Qing Li +3 more
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Aquaculture Nutrition, 2023 Selenoprotein is a feed additive that can overcome oxidative stress in intensive Pacific white shrimp (Litopenaeus vannamei) culture. This study evaluated the effects of selenoprotein supplementation at various doses on Pacific white shrimp’s ...
Rafi Kemal +4 more
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The expression of essential selenoproteins during development requires SECIS-binding protein 2–like
Life Science Alliance, 2022 This work reveals that the Sbp2 paralogue, Secisbp2-like, is required for selective selenoprotein synthesis when the function of Sbp2 is compromised. The dietary requirement for selenium is based on its incorporation into selenoproteins, which contain ...
Nora T Kiledjian +3 more
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Selenoproteins and Metastasis [PDF]
, 2017 Cancer survival is largely impacted by the dissemination of cancer cells from the original tumor site to secondary tissues or organs through metastasis. Targets for antimetastatic therapies have recently become a focus of research, but progress will require a better understanding of the molecular mechanisms driving metastasis.
Michael P, Marciel, Peter R, Hoffmann
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Selenium regulation of selenoprotein enzyme activity and transcripts in a pilot study with Founder strains from the Collaborative Cross. [PDF]
PLoS ONE, 2018 Rodents and humans have 24-25 selenoproteins, and these proteins contain the 21st amino acid, selenocysteine, incorporated co-translationally into the peptide backbone in a series of reactions dependent on at least 6 unique gene products. In selenium (Se)
Roger A Sunde
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Bioinformatics of Selenoproteins
Antioxidants & Redox Signaling, 2020 Significance: Bioinformatics has brought important insights into the field of selenium research. The progress made in the development of computational tools in the last two decades, coordinated with growing genome resources, provided new opportunities to study selenoproteins.
Didac, Santesmasses +2 more
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Veterinarski glasnik, 2015 Selenium is an essential trace element with multi significant role in the body. In contrast to other trace elements that appear as cofactors of certain enzymes, its physiological role is directly related to functions of proteins in composition of which it is cotranslationally installed by atypical amino acid selenocysteine.
Milanović, Svetlana +2 more
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Trends in selenium utilization in marine microbial world revealed through the analysis of the global ocean sampling (GOS) project. [PDF]
PLoS Genetics, 2008 Selenium is an important trace element that occurs in proteins in the form of selenocysteine (Sec) and in tRNAs in the form of selenouridine. Recent large-scale metagenomics projects provide an opportunity for understanding global trends in trace element
Yan Zhang, Vadim N Gladyshev
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