Selenium and selenoprotein deficiencies induce widespread pyogranuloma formation in mice, while high levels of dietary selenium decrease liver tumor size driven by TGFα. [PDF]
PLoS ONE, 2013 Changes in dietary selenium and selenoprotein status may influence both anti- and pro-cancer pathways, making the outcome of interventions different from one study to another.
Mohamed E Moustafa +13 more
doaj +5 more sources
deep-Sep: a deep learning-based method for fast and accurate prediction of selenoprotein genes in bacteria [PDF]
mSystemsSelenoproteins are a special group of proteins with major roles in cellular antioxidant defense. They contain the 21st amino acid selenocysteine (Sec) in the active sites, which is encoded by an in-frame UGA codon.
Yao Xiao, Yan Zhang
doaj +2 more sources
Gender differences in plasma element concentrations and associations between selenoprotein P and iron metabolism in a community-based cohort study [PDF]
Scientific ReportsEssential trace elements, such as iron (Fe) and selenium (Se), play physiological roles in our body, whereas environmental toxic metals, such as arsenic (As), cadmium (Cd), and mercury (Hg), are known to be associated with various disease risks. However,
Yoshiro Saito +11 more
doaj +2 more sources
Novel selenoprotein neighborhoods suggest specialized biochemical processes [PDF]
mSystemsProkaryotic genomes encode selenoproteins sparsely, roughly one protein per 5,000. Finding novel selenoprotein families can expose unknown biological processes that are enabled, or at least enhanced, by having a selenium atom replace a sulfur atom in ...
Daniel H. Haft, Igor Tolstoy
doaj +2 more sources
eIF3 Interacts with Selenoprotein mRNAs
Biomolecules, 2022 The synthesis of selenoproteins requires the co-translational recoding of an in-frame UGASec codon. Interactions between the Selenocysteine Insertion Sequence (SECIS) and the SECIS binding protein 2 (SBP2) in the 3′untranslated region (3′UTR) of ...
Hassan Hayek +2 more
doaj +1 more source
Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans
Frontiers in Nutrition, 2021 Selenoprotein P is a hepatokine with antioxidative properties that eliminate a physiologic burst of reactive oxygen species required for intracellular signal transduction.
Yuki Isobe +13 more
doaj +1 more source
Redox Biology, 2023 TXNL1 (also named TRP32, for thioredoxin related protein of 32 kDa) is a cytosolic thioredoxin-fold protein expressed in all cell types and conserved from yeast to mammals, but with yet poorly known function.
Attila Andor +6 more
doaj +1 more source
A randomized trial of selenium supplementation and risk of type-2 diabetes, as assessed by plasma adiponectin [PDF]
, 2012 Background: Evidence that selenium affects the risk of type-2 diabetes is conflicting, with observational studies and a few randomized trials showing both lower and higher risk linked to the level of selenium intake and status. We investigated the effect
Eliseo Guallar +6 more
core +12 more sources
Journal of Biological Chemistry, 2009 Selenium is an essential micronutrient for man and animals. The role of selenium has been attributed largely to its presence in selenoproteins as the 21st amino acid, selenocysteine (Sec, U). Sec is encoded by TGA in DNA. A unique mechanism is used to decode the UGA codon in mRNA to co-translationally incorporate Sec into the growing polypeptide ...
Jun, Lu, Arne, Holmgren
openaire +2 more sources
Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts
Nature Communications, 2021 Selenoproteins containing selenium in the form of selenocysteine are critical for bone remodeling. However, their underlying mechanism of action is not fully understood.
Hyunsook Kim +15 more
semanticscholar +1 more source