Results 21 to 30 of about 27,808 (261)

Loss of selenoprotein W in murine macrophages alters the hierarchy of selenoprotein expression, redox tone, and mitochondrial functions during inflammation

Redox Biology, 2022
Macrophages play a pivotal role in mediating inflammation and subsequent resolution of inflammation. The availability of selenium as a micronutrient and the subsequent biosynthesis of selenoproteins, containing the 21st amino acid selenocysteine (Sec ...
Sougat Misra, Tai-Jung Lee, Aswathy Sebastian, J. McGuigan, Chang Liao, Imhoi Koo, A. Patterson, R. M. Rossi, Molly A. Hall, I. Albert, K. S. Prabhu   +10 more
semanticscholar   +1 more source

Role of selenoprotein P expression in the function of pancreatic β cells: Prevention of ferroptosis-like cell death and stress-induced nascent granule degradation.

Free Radical Biology & Medicine, 2022
Selenoprotein P (SELENOP) is a major selenium (Se)-containing protein (selenoprotein) in human plasma that is mainly synthesized in the liver. SELENOP transports Se to the cells, while SELENOP synthesized in peripheral tissues is incorporated in a ...
Nanako Kitabayashi, Shohei Nakao, Yuichiro Mita, Kotoko Arisawa, Takayuki Hoshi, T. Toyama, Kiyo-aki Ishii, T. Takamura, N. Noguchi, Yoshiro Saito   +9 more
semanticscholar   +1 more source

Expression of Selenoproteins Is Maintained in Mice Carrying Mutations in SECp43, the tRNA Selenocysteine 1 Associated Protein (Trnau1ap). [PDF]

PLoS ONE, 2015
Selenocysteine tRNA 1 associated protein (Trnau1ap) has been characterized as a tRNA[Ser]Sec-binding protein of 43 kDa, hence initially named SECp43. Previous studies reported its presence in complexes containing tRNA[Ser]Sec implying a role of SECp43 as
Yassin Mahdi, Xue-Ming Xu, Bradley A Carlson, Noelia Fradejas, Paul Günter, Doreen Braun, Eileen Southon, Lino Tessarollo, Dolph L Hatfield, Ulrich Schweizer   +9 more
doaj   +1 more source

Selenoprotein P Concentrations in the Cerebrospinal Fluid and Serum of Individuals Affected by Amyotrophic Lateral Sclerosis, Mild Cognitive Impairment and Alzheimer’s Dementia

International Journal of Molecular Sciences, 2022
Selenoprotein P, a selenium-transporter protein, has been hypothesized to play a role in the etiology of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Alzheimer’s dementia (AD).
T. Urbano, M. Vinceti, J. Mandrioli, A. Chiari, T. Filippini, R. Bedin, M. Tondelli, C. Simonini, G. Zamboni, Misaki Shimizu, Yoshiro Saito   +10 more
semanticscholar   +1 more source

Relaxation of selective constraints causes independent selenoprotein extinction in insect genomes. [PDF]

PLoS ONE, 2008
BACKGROUND: Selenoproteins are a diverse family of proteins notable for the presence of the 21st amino acid, selenocysteine. Until very recently, all metazoan genomes investigated encoded selenoproteins, and these proteins had therefore been believed to ...
Charles E Chapple, Roderic Guigó
doaj   +1 more source

Increases in Hepatokine Selenoprotein P Levels Are Associated With Hepatic Hypoperfusion and Predict Adverse Prognosis in Patients With Heart Failure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Although multiorgan networks are involved in the pathophysiology of heart failure (HF), interactions of the heart and the liver have not been fully understood.
Ryohei Takeishi, Tomofumi Misaka, Yasuhiro Ichijo, Shinji Ishibashi, Mitsuko Matsuda, Yukio Yamadera, Himika Ohara, Yukiko Sugawara, Yu Hotsuki, Koichiro Watanabe, Fumiya Anzai, Yu Sato, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Kazuhiko Nakazato, Akiomi Yoshihisa, Yasuchika Takeishi   +18 more
doaj   +1 more source

Human Genetic Disorders Resulting in Systemic Selenoprotein Deficiency

International Journal of Molecular Sciences, 2021
Selenium, a trace element fundamental to human health, is incorporated as the amino acid selenocysteine (Sec) into more than 25 proteins, referred to as selenoproteins.
E. Schoenmakers, K. Chatterjee
semanticscholar   +1 more source

Selenoproteins [PDF]

Veterinarski glasnik, 2015
Selenium is an essential trace element with multi significant role in the body. In contrast to other trace elements that appear as cofactors of certain enzymes, its physiological role is directly related to functions of proteins in composition of which it is cotranslationally installed by atypical amino acid selenocysteine.
Milanović, Svetlana, Jovanović, Ivan B., Valčić, Olivera   +2 more
openaire   +2 more sources

The algal selenoproteomes

BMC Genomics, 2020
Background Selenium is an essential trace element, and selenocysteine (Sec, U) is its predominant form in vivo. Proteins that contain Sec are selenoproteins, whose special structural features include not only the TGA codon encoding Sec but also the SECIS
Liang Jiang, Yiqian Lu, Lin Zheng, Gaopeng Li, Lianchang Chen, Maona Zhang, Jiazuan Ni, Qiong Liu, Yan Zhang   +8 more
doaj   +1 more source

Pituitary and liver selenoprotein transcriptome profiles of grazing steers and their sensitivity to the form of selenium in vitamin-mineral mixes

Frontiers in Animal Science, 2022
Many supplemental Se-dependent metabolic effects are mediated through the function of selenoproteins. The full complement and relative abundance of selenoproteins expressed by highly metabolic cattle tissues have not been characterized in cattle.
Qing Li, Kuey C. Chen, Phillip J. Bridges, James C. Matthews   +3 more
doaj   +1 more source