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Selenoproteins and Metastasis [PDF]
, 2017 Cancer survival is largely impacted by the dissemination of cancer cells from the original tumor site to secondary tissues or organs through metastasis. Targets for antimetastatic therapies have recently become a focus of research, but progress will require a better understanding of the molecular mechanisms driving metastasis.
Michael P, Marciel, Peter R, Hoffmann
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Trends in selenium utilization in marine microbial world revealed through the analysis of the global ocean sampling (GOS) project. [PDF]
PLoS Genetics, 2008 Selenium is an important trace element that occurs in proteins in the form of selenocysteine (Sec) and in tRNAs in the form of selenouridine. Recent large-scale metagenomics projects provide an opportunity for understanding global trends in trace element
Yan Zhang, Vadim N Gladyshev
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A novel protein kinase-like domain in a selenoprotein, widespread in the tree of life. [PDF]
, 2012 Selenoproteins serve important functions in many organisms, usually providing essential oxidoreductase enzymatic activity, often for defense against toxic xenobiotic substances.
Marcin Grynberg +15 more
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Veterinarski glasnik, 2015 Selenium is an essential trace element with multi significant role in the body. In contrast to other trace elements that appear as cofactors of certain enzymes, its physiological role is directly related to functions of proteins in composition of which it is cotranslationally installed by atypical amino acid selenocysteine.
Milanović, Svetlana +2 more
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Selenium in biology: Facts and medical perspectives [PDF]
, 2000 Several decades after the discovery of setenium as an essential trace element in vertebrates approximately 20 eukaryotic and more than 15 prokaryotic selenoproteins containing the 21(st) proteinogenic amino acid, selenocysteine, have been identified ...
Flohé, Leopold +5 more
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Nature Communications, 2022 Stop codon recoding is a unique mechanism for selenoprotein biogenesis. Here, the authors report regulatory systems for selenoprotein expression during skeletal muscle differentiation by regulating A-to-I RNA editing and stop codon recoding.
Yuta Noda, Shunpei Okada, Tsutomu Suzuki
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Chemical Synthesis of Human Selenoprotein F and Elucidation of Its Thiol-Disulfide Oxidoreductase Activity [PDF]
, 2022 Selenoprotein F (SelF) is an endoplasmic reticulum-residing eukaryotic protein that contains a selenocysteine (Sec) residue. It has been suggested to be involved in a number of physiological processes by acting as a thiol-disulfide oxidoreductase, but ...
Hongmei, Liu, Chunmao, He, Peisi, Liao
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BMC Genomics, 2010 Background Computational methods for identifying selenoproteins have been developed rapidly in recent years. However, it is still difficult to identify the open reading frame (ORF) of eukaryotic selenoprotein gene, because the TGA codon for a ...
Jiang Liang, Liu Qiong, Ni Jiazuan
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Selenium, Selenoproteins, and Immunity [PDF]
Nutrients, 2018 Selenium is an essential micronutrient that plays a crucial role in development and a wide variety of physiological processes including effect immune responses. The immune system relies on adequate dietary selenium intake and this nutrient exerts its biological effects mostly through its incorporation into selenoproteins. The selenoproteome contains 25
Joseph Avery, Peter Hoffmann
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Modern concept of biological identification of selenoproteins
Regulatory Mechanisms in Biosystems, 2018 Humans possess 25 selenoproteins, approximately half of which are enzymes (selenoenzymes) required for preventing, regulating, or reversing oxidative damage, while others participate in providing calcium metabolism, thyroid hormone maintenance, protein ...
N. V. Stanishevska
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