Results 21 to 30 of about 11,591 (176)
Assessment of reagents for selenocysteine conjugation and the stability of selenocysteine adducts [PDF]
Organic & Biomolecular Chemistry, 2016 The allenamide functional group reacts with selenocysteine with notably high efficiency, leads to antibody conjugates with remarkable stability, and shows exquisite selectivity for selenocysteine conjugation.
Lee, Pedzisa +3 more
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Selenium Metabolism and Selenoproteins in Prokaryotes: A Bioinformatics Perspective
Biomolecules, 2022 Selenium (Se) is an important trace element that mainly occurs in the form of selenocysteine in selected proteins. In prokaryotes, Se is also required for the synthesis of selenouridine and Se-containing cofactor. A large number of selenoprotein families
Yan Zhang +5 more
doaj +1 more source
Going Forward and Back: The Complex Evolutionary History of the GPx
Biology, 2021 There is large diversity among glutathione peroxidase (GPx) enzymes regarding their function, structure, presence of the highly reactive selenocysteine (SeCys) residue, substrate usage, and reducing agent preference.
Thomaz Stumpf Trenz +5 more
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On the road to selenocysteine [PDF]
Proceedings of the National Academy of Sciences, 2004 Decades ago, a mammalian tRNA that exclusively bound the UGA stop codon was identified by using the triplet binding assay that was instrumental in deciphering the genetic code (1). The possibility of a naturally occurring suppressor tRNA presented the dilemma of explaining the biological function of such a molecule.
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Plants, 2023 Cadmium (Cd) is a common agricultural soil pollutant, which does serious harm to the environment and the human body. In this study, Brassica juncea was treated with different concentrations of CdCl2 and Na2SeO3.
Linling Li +6 more
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Nature Communications, 2016 Specialized translation elongation factors (eEFSec and SelB) promote selenocysteine incorporation into proteins. Here, the authors report the structure of human eEFSec, examine its interactions with guanine nucleotides, and propose a non-canonical ...
Malgorzata Dobosz-Bartoszek +6 more
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Biomedicines, 2018 Spider venoms are a rich source of insecticidal peptide toxins. Their development as bioinsecticides has, however, been hampered due to concerns about potential lack of stability and oral bioactivity.
Volker Herzig +11 more
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Selenium in the Treatment of Graves’ Hyperthyroidism and Eye Disease
Frontiers in Endocrinology, 2021 Based on the role of oxidative stress in the pathogenesis of Graves’ hyperthyroidism (GH) and Graves’ Orbitopathy (GO), a therapy with the antioxidant agent selenium has been proposed and a number of studies have been performed, both in vitro and in vivo.
Giulia Lanzolla +2 more
doaj +1 more source
Programmed Deviations of Ribosomes From Standard Decoding in Archaea
Frontiers in Microbiology, 2021 Genetic code decoding, initially considered to be universal and immutable, is now known to be flexible. In fact, in specific genes, ribosomes deviate from the standard translational rules in a programmed way, a phenomenon globally termed recoding ...
Federica De Lise +12 more
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An Ecological Basis for Dual Genetic Code Expansion in Marine Deltaproteobacteria
Frontiers in Microbiology, 2021 Marine benthic environments may be shaped by anthropogenic and other localized events, leading to changes in microbial community composition evident decades after a disturbance.
Veronika Kivenson +2 more
doaj +1 more source