Results 11 to 20 of about 11,591 (176)

Effects of Selenocysteine Substitution on the Cyclotide Kalata B2. [PDF]

Chembiochem
Selenocysteine (Sec) substitution of any of the native complementary cysteine (Cys) residues of the cyclotide kalata B2 preserves the structure, cytotoxicity, and membrane‐binding activity while enhancing its folding efficiency. The study shows the conservative nature and folding benefit of selenocysteine replacement in kalata B2.
de Boda RLB, Henriques ST, Huang YH, Hernandez CC, Sabido PMG, Craik DJ.   +5 more
europepmc   +2 more sources

The molecular biology of selenocysteine [PDF]

Biomolecular Concepts, 2013
Selenium is an essential trace element that is incorporated into 25 human proteins as the amino acid selenocysteine (Sec). The incorporation of this amino acid turns out to be a fascinating problem in molecular biology because Sec is encoded by a stop ...
Gonzalez-Flores Jonathan N., Shetty Sumangala P., Dubey Aditi, Copeland Paul R.   +3 more
doaj   +3 more sources

Exploring the Antioxidant Roles of Cysteine and Selenocysteine in Cellular Aging and Redox Regulation [PDF]

Biomolecules
Aging is a complex, universal biological process characterized by the progressive and irreversible decline of physiological functions across multiple organ systems.
Marta Pace, Chiara Giorgi, Giorgia Lombardozzi, Annamaria Cimini, Vanessa Castelli, Michele d’Angelo   +5 more
doaj   +2 more sources

In silico discovery of selenocysteine-containing variants of Group 4 [NiFe] hydrogenases [PDF]

Frontiers in Microbiology
[NiFe] hydrogenases reversibly catalyze hydrogen oxidation and proton reduction at a Ni–Fe active site coordinated by four cysteine (Cys) residues in two CXXC motifs within the catalytic large subunit.
Masamitsu Takano, Masao Inoue, Riku Aono, Anna Ochi, Hisaaki Mihara   +4 more
doaj   +2 more sources

Recent advances in exploring the composition and evolution of the prokaryotic selenoproteome [PDF]

Applied and Environmental Microbiology
Selenoproteins, a unique class of proteins critical for cellular antioxidant defense, are characterized by the incorporation of selenocysteine (Sec) in their active sites.
Yan Zhang, Shuting Wang, Hengtao Li, Xuan Chen   +3 more
doaj   +2 more sources

Indirect Routes to Aminoacyl-tRNA: The Diversity of Prokaryotic Cysteine Encoding Systems

Frontiers in Genetics, 2022
Universally present aminoacyl-tRNA synthetases (aaRSs) stringently recognize their cognate tRNAs and acylate them with one of the proteinogenic amino acids.
Takahito Mukai, Takahito Mukai, Kazuaki Amikura, Xian Fu, Dieter Söll, Dieter Söll, Ana Crnković, Ana Crnković   +7 more
doaj   +1 more source

Comparative analysis of CO2 reduction by soluble Escherichia coli formate dehydrogenase H and its selenocysteine-to-cysteine substitution variant

Journal of CO2 Utilization, 2023
Metal-dependent formate dehydrogenases (Me-FDHs) are highly active CO2-reducing enzymes operating at low redox potentials and employ either molybdenum or tungsten to reduce the bound substrate.
Feilong Li, Silvan Scheller, Michael Lienemann   +2 more
doaj   +1 more source

Selenocysteine in Trypanosoma evansi: Identification of the Genes selb, selc, seld, pstk, seltryp and the Selenophosphate Synthetase Protein

Acta Protozoologica, 2021
Selenoproteins have been described in all three domains of life and their function has been mainly associated with oxidative stress defense.
Kaio Cesar Simiano Tavares, Maria Gabriela Casagrande Dambrós, André Saraiva Leão Antunes, Pietro Martin Danziato, Patricia Hermes Stoco, Aline Daiane Schlindwein, Renato Simões Moreira, Luiz Claudio Miletti   +7 more
doaj   +1 more source

From Recoding to Peptides for MHC Class I Immune Display: Enriching Viral Expression, Virus Vulnerability and Virus Evasion

Viruses, 2021
Many viruses, especially RNA viruses, utilize programmed ribosomal frameshifting and/or stop codon readthrough in their expression, and in the decoding of a few a UGA is dynamically redefined to specify selenocysteine.
John F. Atkins, Kate M. O’Connor, Pramod R. Bhatt, Gary Loughran   +3 more
doaj   +1 more source

Optimized methyl donor and reduced precursor degradation pathway for seleno-methylselenocysteine production in Bacillus subtilis

Microbial Cell Factories, 2023
Background Seleno-methylselenocysteine (SeMCys) is an effective component of selenium supplementation with anti-carcinogenic potential that can ameliorate neuropathology and cognitive deficits.
Xian Yin, Meiyi Zhao, Yu Zhou, Hulin Yang, Yonghong Liao, Fenghuan Wang   +5 more
doaj   +1 more source