Results 11 to 20 of about 11,168 (173)
Sensors, 2020 The content of selenocysteine in cells has an important effect on a variety of human diseases, and the detection of selenocysteine by fluorescent sensors in vivo has shown many advantages. In order to further develop fast-reaction-time, good-selectivity,
Zongcheng Wang +2 more
exaly +3 more sources
Facile Recoding of Selenocysteine in Nature [PDF]
Angewandte Chemie - International Edition, 2016 AbstractSelenocysteine (Sec or U) is encoded by UGA, a stop codon reassigned by a Sec‐specific elongation factor and a distinctive RNA structure. To discover possible code variations in extant organisms we analyzed 6.4 trillion base pairs of metagenomic sequences and 24 903 microbial genomes for tRNASec species.
Takahito Mukai +2 more
exaly +6 more sources
Antioxidants, 2019 The enzyme selenocysteine β-lyase (SCLY) was first isolated in 1982 from pig livers, followed by its identification in bacteria. SCLY works as a homodimer, utilizing pyridoxal 5’-phosphate as a cofactor, and catalyzing the specific ...
Lucia Seale, Seale Lucia A
exaly +3 more sources
Retinal Gatekeepers: Molecular Mechanism and Therapeutic Role of Cysteine and Selenocysteine [PDF]
BiomoleculesOxidative stress is a key contributor to retinal degeneration, as the retina is highly metabolically active and exposed to constant light stimulation. This review explores the crucial roles of cysteine and selenocysteine in redox homeostasis and retinal ...
Eleonora Maceroni +4 more
doaj +2 more sources
The molecular biology of selenocysteine [PDF]
Biomolecular Concepts, 2013 Selenium is an essential trace element that is incorporated into 25 human proteins as the amino acid selenocysteine (Sec). The incorporation of this amino acid turns out to be a fascinating problem in molecular biology because Sec is encoded by a stop ...
Gonzalez-Flores Jonathan N. +3 more
doaj +3 more sources
Exploring the Antioxidant Roles of Cysteine and Selenocysteine in Cellular Aging and Redox Regulation [PDF]
BiomoleculesAging is a complex, universal biological process characterized by the progressive and irreversible decline of physiological functions across multiple organ systems.
Marta Pace +5 more
doaj +2 more sources
Selenocysteine-containing proteins in mammals
Journal of Biomedical Science, 1999 Since the recent discovery of selenocysteine as the 21st amino acid in protein, the field of selenium biology has rapidly expanded. Twelve mammalian selenoproteins have been characterized to date and each contains selenocysteine that is incorporated in response to specific UGA code words.
Vadim Gladyshev +2 more
exaly +4 more sources
Novel selenoprotein neighborhoods suggest specialized biochemical processes [PDF]
mSystemsProkaryotic genomes encode selenoproteins sparsely, roughly one protein per 5,000. Finding novel selenoprotein families can expose unknown biological processes that are enabled, or at least enhanced, by having a selenium atom replace a sulfur atom in ...
Daniel H. Haft, Igor Tolstoy
doaj +2 more sources
Recent advances in exploring the composition and evolution of the prokaryotic selenoproteome [PDF]
Applied and Environmental MicrobiologySelenoproteins, a unique class of proteins critical for cellular antioxidant defense, are characterized by the incorporation of selenocysteine (Sec) in their active sites.
Yan Zhang +3 more
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DeepSecMS Advances DIA‐Based Selenoproteome Profiling Through Cys‐to‐Sec Proxy Training [PDF]
Advanced ScienceSelenoproteins, defined as proteins containing the 21st amino acid, selenocysteine (Sec, U), are functionally important but rare, with only 25 selenoproteins characterized in the entire human proteome to date.
Chenfang Si +5 more
doaj +2 more sources