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Selenoproteins [PDF]

open access: yesVeterinarski Glasnik, 2015
Selenium is an essential trace element with multi significant role in the body. In contrast to other trace elements that appear as cofactors of certain enzymes, its physiological role is directly related to functions of proteins in composition ...
Milanović Svetlana   +2 more
doaj   +3 more sources

Selenoproteins in Health

open access: yesMolecules, 2023
Selenium (Se) is a naturally occurring essential micronutrient that is required for human health. The existing form of Se includes inorganic and organic.
Ziqi Qi, Alex Duan, Ken Ng
doaj   +4 more sources

Evolution of selenoproteins in the metazoan [PDF]

open access: yesBMC Genomics, 2012
Background The selenocysteine (Sec) containing proteins, selenoproteins, are an important group of proteins present throughout all 3 kingdoms of life.
Jiang Liang, Ni Jiazuan, Liu Qiong
doaj   +3 more sources

Selenoproteins [PDF]

open access: yesJournal of Biological Chemistry, 2009
Selenium is an essential micronutrient for man and animals. The role of selenium has been attributed largely to its presence in selenoproteins as the 21st amino acid, selenocysteine (Sec, U). Sec is encoded by TGA in DNA. A unique mechanism is used to decode the UGA codon in mRNA to co-translationally incorporate Sec into the growing polypeptide ...
Jun, Lu, Arne, Holmgren
openaire   +2 more sources

Relaxation of selective constraints causes independent selenoprotein extinction in insect genomes. [PDF]

open access: yesPLoS ONE, 2008
BACKGROUND: Selenoproteins are a diverse family of proteins notable for the presence of the 21st amino acid, selenocysteine. Until very recently, all metazoan genomes investigated encoded selenoproteins, and these proteins had therefore been believed to ...
Charles E Chapple, Roderic Guigó
doaj   +1 more source

Selenium supplementation influences mice testicular selenoproteins driven by gut microbiota

open access: yesScientific Reports, 2022
Selenium is a well-known essential element with important roles in human reproductive health mainly due to its antioxidant character. This study aimed to investigate the potential role of selenoproteins on gut microbiota and male reproductive health.
Sara Ramírez-Acosta   +5 more
doaj   +1 more source

Macrophage Selenoproteins Restrict Intracellular Replication of Francisella tularensis and Are Essential for Host Immunity

open access: yesFrontiers in Immunology, 2021
The essential micronutrient Selenium (Se) is co-translationally incorporated as selenocysteine into proteins. Selenoproteins contain one or more selenocysteines and are vital for optimum immunity.
Rachel L. Markley   +25 more
doaj   +1 more source

The role of selenoproteins in neurodevelopment and neurological function: Implications in autism spectrum disorder

open access: yesFrontiers in Molecular Neuroscience, 2023
Selenium and selenoproteins play a role in many biological functions, particularly in brain development and function. This review outlines the role of each class of selenoprotein in human brain function.
Supriya Behl   +3 more
doaj   +1 more source

Bioinformatics of Selenoproteins

open access: yesAntioxidants & Redox Signaling, 2020
Significance: Bioinformatics has brought important insights into the field of selenium research. The progress made in the development of computational tools in the last two decades, coordinated with growing genome resources, provided new opportunities to study selenoproteins.
Didac, Santesmasses   +2 more
openaire   +3 more sources

Selenoprotein Gene Nomenclature [PDF]

open access: yesJournal of Biological Chemistry, 2016
The human genome contains 25 genes coding for selenocysteine-containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis. Selenoprotein enzymes with known functions are designated according to these functions: TXNRD1, TXNRD2, and TXNRD3 (thioredoxin reductases), GPX1, GPX2, GPX3, GPX4, and
Gladyshev, Vadim   +52 more
openaire   +8 more sources

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