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Selenoprotein Gene Nomenclature [PDF]
Journal of Biological Chemistry, 2016 The human genome contains 25 genes coding for selenocysteine-containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis. Selenoprotein enzymes with known functions are designated according to these functions: TXNRD1, TXNRD2, and TXNRD3 (thioredoxin reductases), GPX1, GPX2, GPX3, GPX4, and
Gladyshev, Vadim +52 more
openaire +11 more sources
Veterinarski Glasnik, 2015 Selenium is an essential trace element with multi significant role in the body. In contrast to other trace elements that appear as cofactors of certain enzymes, its physiological role is directly related to functions of proteins in composition ...
Milanović Svetlana +2 more
doaj +3 more sources
Molecules, 2023 Selenium (Se) is a naturally occurring essential micronutrient that is required for human health. The existing form of Se includes inorganic and organic.
Ziqi Qi, Alex Duan, Ken Ng
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A randomized trial of selenium supplementation and risk of type-2 diabetes, as assessed by plasma adiponectin [PDF]
, 2012 Background: Evidence that selenium affects the risk of type-2 diabetes is conflicting, with observational studies and a few randomized trials showing both lower and higher risk linked to the level of selenium intake and status. We investigated the effect
Eliseo Guallar +6 more
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Metabolism of Selenium, Selenocysteine, and Selenoproteins in Ferroptosis in Solid Tumor Cancers
Biomolecules, 2022 A potential target of precision nutrition in cancer therapeutics is the micronutrient selenium (Se). Se is metabolized and incorporated as the amino acid selenocysteine (Sec) into 25 human selenoproteins, including glutathione peroxidases (GPXs) and ...
Briana K. Shimada +3 more
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Journal of Biological Chemistry, 2009 Selenium is an essential micronutrient for man and animals. The role of selenium has been attributed largely to its presence in selenoproteins as the 21st amino acid, selenocysteine (Sec, U). Sec is encoded by TGA in DNA. A unique mechanism is used to decode the UGA codon in mRNA to co-translationally incorporate Sec into the growing polypeptide ...
Jun, Lu, Arne, Holmgren
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Relaxation of selective constraints causes independent selenoprotein extinction in insect genomes. [PDF]
PLoS ONE, 2008 BACKGROUND: Selenoproteins are a diverse family of proteins notable for the presence of the 21st amino acid, selenocysteine. Until very recently, all metazoan genomes investigated encoded selenoproteins, and these proteins had therefore been believed to ...
Charles E Chapple, Roderic Guigó
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Selenium supplementation influences mice testicular selenoproteins driven by gut microbiota
Scientific Reports, 2022 Selenium is a well-known essential element with important roles in human reproductive health mainly due to its antioxidant character. This study aimed to investigate the potential role of selenoproteins on gut microbiota and male reproductive health.
Sara Ramírez-Acosta +5 more
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Frontiers in Immunology, 2021 The essential micronutrient Selenium (Se) is co-translationally incorporated as selenocysteine into proteins. Selenoproteins contain one or more selenocysteines and are vital for optimum immunity.
Rachel L. Markley +25 more
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Frontiers in Molecular Neuroscience, 2023 Selenium and selenoproteins play a role in many biological functions, particularly in brain development and function. This review outlines the role of each class of selenoprotein in human brain function.
Supriya Behl +3 more
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