Results 21 to 30 of about 7,542 (180)
Selenoproteins and Metastasis [PDF]
, 2017 Cancer survival is largely impacted by the dissemination of cancer cells from the original tumor site to secondary tissues or organs through metastasis. Targets for antimetastatic therapies have recently become a focus of research, but progress will require a better understanding of the molecular mechanisms driving metastasis.
Michael P, Marciel, Peter R, Hoffmann
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Role of Selenoproteins in Redox Regulation of Signaling and the Antioxidant System: A Review
Antioxidants, 2020 Selenium is a vital trace element present as selenocysteine (Sec) in proteins that are, thus, known as selenoproteins. Humans have 25 selenoproteins, most of which are functionally characterized as oxidoreductases, where the Sec residue plays a catalytic
Ying Zhang +7 more
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The Neurobiology of Selenium: Looking Back and to the Future
Frontiers in Neuroscience, 2021 Eighteen years ago, unexpected epileptic seizures in Selenop-knockout mice pointed to a potentially novel, possibly underestimated, and previously difficult to study role of selenium (Se) in the mammalian brain.
Ulrich Schweizer +3 more
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Gene expression evaluation of antioxidant enzymes in patients with hepatocellular carcinoma: RT-qPCR and bioinformatic analyses [PDF]
Genetics and Molecular Biology, 2021 Any condition leading to chronic liver disease is a potential oncogenic agent for hepatocellular carcinoma (HCC). Alterations in the expression of antioxidant enzymes could alter the redox balance. Our aim was to evaluate the expression of the genes GPX1,
Andressa de Freitas Alves +6 more
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Journal of Animal Science and Biotechnology, 2023 Background The skeletal muscle of pigs is vulnerable to oxidative damage, resulting in growth retardation. Selenoproteins are important components of antioxidant systems for animals, which are generally regulated by dietary selenium (Se) level.
Jinzhong Jing +12 more
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Deciphering the Role of Selenoprotein M
Antioxidants, 2023 Selenocysteine (Sec), the 21st amino acid, is structurally similar to cysteine but with a sulfur to selenium replacement. This single change retains many of the chemical properties of cysteine but often with enhanced catalytic and redox activity ...
Lance G. A. Nunes +4 more
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Environmental and Circadian Regulation Combine to Shape the Rhythmic Selenoproteome
Cells, 2022 The circadian clock orchestrates an organism’s endogenous processes with environmental 24 h cycles. Redox homeostasis and the circadian clock regulate one another to negate the potential effects of our planet’s light/dark cycle on the generation of ...
Holly Kay +2 more
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Selenium, Selenoproteins, and Immunity [PDF]
Nutrients, 2018 Selenium is an essential micronutrient that plays a crucial role in development and a wide variety of physiological processes including effect immune responses. The immune system relies on adequate dietary selenium intake and this nutrient exerts its biological effects mostly through its incorporation into selenoproteins. The selenoproteome contains 25
Joseph Avery, Peter Hoffmann
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Selenoproteins are essential for proper keratinocyte function and skin development. [PDF]
PLoS ONE, 2010 Dietary selenium is known to protect skin against UV-induced damage and cancer and its topical application improves skin surface parameters in humans, while selenium deficiency compromises protective antioxidant enzymes in skin.
Aniruddha Sengupta +6 more
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Cells, 2023 Cardiac lipotoxicity is an important contributor to cardiovascular complications during obesity. Given the fundamental role of the endoplasmic reticulum (ER)-resident Selenoprotein T (SELENOT) for cardiomyocyte differentiation and protection and for the ...
Carmine Rocca +19 more
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