Results 21 to 30 of about 10,333 (214)

Selenoprotein Gene Nomenclature [PDF]

Journal of Biological Chemistry, 2016
The human genome contains 25 genes coding for selenocysteine-containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis. Selenoprotein enzymes with known functions are designated according to these functions: TXNRD1, TXNRD2, and TXNRD3 (thioredoxin reductases), GPX1, GPX2, GPX3, GPX4, and
Gladyshev, Vadim, Arnér, Elias, Berry, Marla, Brigelius-Flohé, Regina, Bruford, Elspeth, Burk, Raymond, Carlson, Bradley, Castellano, Sergi, Chavatte, Laurent, Conrad, Marcus, Copeland, Paul, Diamond, Alan, Driscoll, Donna, Ferreiro, Ana, Flohé, Leopold, Green, Fiona, Guigó, Roderic, Handy, Diane, Hatfield, Dolph, Hesketh, John, Hoffmann, Peter, Holmgren, Arne, Hondal, Robert, Howard, Michael, Huang, Kaixun, Kim, Hwa-Young, Kim, Ick Young, Köhrle, Josef, Krol, Alain, Kryukov, Gregory, Lee, Byeong Jae, Lee, Byung Cheon, Lei, Xin Gen, Liu, Qiong, Lescure, Alain, Lobanov, Alexei, Loscalzo, Joseph, Maiorino, Matilde, Mariotti, Marco, Sandeep Prabhu, K., Rayman, Margaret, Rozovsky, Sharon, Salinas, Gustavo, Schmidt, Edward, Schomburg, Lutz, Schweizer, Ulrich, Simonović, Miljan, Sunde, Roger, Tsuji, Petra, Tweedie, Susan, Ursini, Fulvio, Whanger, Philip, Zhang, Yan   +52 more
openaire   +8 more sources

The function of intrinsically disordered selenoproteins

, 2023
Rozovsky, SharonSELENOS and SELENOK are intrinsically disordered selenoproteins that take part in the endoplasmic-reticulum-associated degradation (ERAD) pathway, which degrades misfolded proteins and maintains cellular protein hemostasis.
Cheng, Rujin
core   +1 more source

Selenoproteins and Metastasis [PDF]

, 2017
Cancer survival is largely impacted by the dissemination of cancer cells from the original tumor site to secondary tissues or organs through metastasis. Targets for antimetastatic therapies have recently become a focus of research, but progress will require a better understanding of the molecular mechanisms driving metastasis.
Michael P, Marciel, Peter R, Hoffmann
openaire   +2 more sources

The Neurobiology of Selenium: Looking Back and to the Future

Frontiers in Neuroscience, 2021
Eighteen years ago, unexpected epileptic seizures in Selenop-knockout mice pointed to a potentially novel, possibly underestimated, and previously difficult to study role of selenium (Se) in the mammalian brain.
Ulrich Schweizer, Simon Bohleber, Wenchao Zhao, Noelia Fradejas-Villar   +3 more
doaj   +1 more source

Bioinformatics of Selenoproteins

Antioxidants & Redox Signaling, 2020
Significance: Bioinformatics has brought important insights into the field of selenium research. The progress made in the development of computational tools in the last two decades, coordinated with growing genome resources, provided new opportunities to study selenoproteins.
Didac, Santesmasses, Marco, Mariotti, Vadim N, Gladyshev   +2 more
openaire   +3 more sources

Metabolic‐Redox Remodeling of Inflammatory Synovium by Mannose‐Modified Selenium Nanoparticles for Osteoarthritis Therapy [PDF]

Advanced science
Elevated GLUT1‐driven glycolysis and disrupted selenoprotein‐dependent redox homeostasis drive osteoarthritic progression. Intra‐articular mannose‐modified selenium nanoparticles (M‐SeNPs) selectively target hypermetabolic synovial cells to reprogram aberrant glycolysis and restore endogenous antioxidant defenses.
Zou Y, Xu C, Li B, Chan L, Xu Y, Su H, Peng R, Luo F, Peng Y, Li Z, Wong V, Zheng X, Ma X, Zha Z, Chen T, Zhang H.   +15 more
europepmc   +2 more sources

Role of Selenoproteins in Redox Regulation of Signaling and the Antioxidant System: A Review

Antioxidants, 2020
Selenium is a vital trace element present as selenocysteine (Sec) in proteins that are, thus, known as selenoproteins. Humans have 25 selenoproteins, most of which are functionally characterized as oxidoreductases, where the Sec residue plays a catalytic
Ying Zhang, Yeon Jin Roh, Seong-Jeong Han, Iha Park, Hae Min Lee, Yong Sik Ok, Byung Cheon Lee, Seung-Rock Lee   +7 more
doaj   +1 more source

Gene expression evaluation of antioxidant enzymes in patients with hepatocellular carcinoma: RT-qPCR and bioinformatic analyses [PDF]

Genetics and Molecular Biology, 2021
Any condition leading to chronic liver disease is a potential oncogenic agent for hepatocellular carcinoma (HCC). Alterations in the expression of antioxidant enzymes could alter the redox balance. Our aim was to evaluate the expression of the genes GPX1,
Andressa de Freitas Alves, Ana Carolina de Moura, Huander Felipe Andreolla, Ana Beatriz Gorini da Veiga, Marilu Fiegenbaum, Márcia Giovenardi, Silvana Almeida   +6 more
doaj   +1 more source

Selenium in biology: Facts and medical perspectives [PDF]

, 2000
Several decades after the discovery of setenium as an essential trace element in vertebrates approximately 20 eukaryotic and more than 15 prokaryotic selenoproteins containing the 21(st) proteinogenic amino acid, selenocysteine, have been identified ...
Flohé, Leopold, Gärtner, Roland, Köhrle, Josef, Brigelius-Flohé, Regina, Böck, August, Meyer, Ortwin, Regina Brigelius-Flohé, Josef Köhrle, Ortwin Meyer, August Böck, Leopold Flohé, Roland Gärtner   +11 more
core   +2 more sources

selenoproteins mRNA levels.pzf

, 2022
selenoproteins mRNA ...
Siran Tan (11971310)
core   +1 more source