Role of Selenoproteins in Redox Regulation of Signaling and the Antioxidant System: A Review
Antioxidants, 2020 Selenium is a vital trace element present as selenocysteine (Sec) in proteins that are, thus, known as selenoproteins. Humans have 25 selenoproteins, most of which are functionally characterized as oxidoreductases, where the Sec residue plays a catalytic
Ying Zhang +7 more
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The Neurobiology of Selenium: Looking Back and to the Future
Frontiers in Neuroscience, 2021 Eighteen years ago, unexpected epileptic seizures in Selenop-knockout mice pointed to a potentially novel, possibly underestimated, and previously difficult to study role of selenium (Se) in the mammalian brain.
Ulrich Schweizer +3 more
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Gene expression evaluation of antioxidant enzymes in patients with hepatocellular carcinoma: RT-qPCR and bioinformatic analyses [PDF]
Genetics and Molecular Biology, 2021 Any condition leading to chronic liver disease is a potential oncogenic agent for hepatocellular carcinoma (HCC). Alterations in the expression of antioxidant enzymes could alter the redox balance. Our aim was to evaluate the expression of the genes GPX1,
Andressa de Freitas Alves +6 more
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Accurate quantification of selenoproteins in human plasma/serum by isotope dilution ICP-MS : focus on selenoprotein P [PDF]
, 2017 Acknowledgements The research leading to these results was funded by the EMRP Joint Research Project “Metrology for metalloproteins” (HLT-05 2012). The EMRP is jointly funded by the EMRP participating countries within EURAMET and the European Union.Peer ...
Busto, M. Estela del Castillo +8 more
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Journal of Animal Science and Biotechnology, 2023 Background The skeletal muscle of pigs is vulnerable to oxidative damage, resulting in growth retardation. Selenoproteins are important components of antioxidant systems for animals, which are generally regulated by dietary selenium (Se) level.
Jinzhong Jing +12 more
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Selenium in biology: Facts and medical perspectives [PDF]
, 2000 Several decades after the discovery of setenium as an essential trace element in vertebrates approximately 20 eukaryotic and more than 15 prokaryotic selenoproteins containing the 21(st) proteinogenic amino acid, selenocysteine, have been identified ...
Brigelius-Flohé, Regina +5 more
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Deciphering the Role of Selenoprotein M
Antioxidants, 2023 Selenocysteine (Sec), the 21st amino acid, is structurally similar to cysteine but with a sulfur to selenium replacement. This single change retains many of the chemical properties of cysteine but often with enhanced catalytic and redox activity ...
Lance G. A. Nunes +4 more
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The single-nucleotide polymorphism (GPX4c718t) in the glutathione peroxidase 4 gene influences endothelial cell function : Interaction with selenium and fatty acids [PDF]
, 2013 © 2013 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH Verlag GmbH & Co.
Akbaraly +31 more
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Environmental and Circadian Regulation Combine to Shape the Rhythmic Selenoproteome
Cells, 2022 The circadian clock orchestrates an organism’s endogenous processes with environmental 24 h cycles. Redox homeostasis and the circadian clock regulate one another to negate the potential effects of our planet’s light/dark cycle on the generation of ...
Holly Kay +2 more
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Selenoproteins and Metastasis [PDF]
, 2017 Cancer survival is largely impacted by the dissemination of cancer cells from the original tumor site to secondary tissues or organs through metastasis. Targets for antimetastatic therapies have recently become a focus of research, but progress will require a better understanding of the molecular mechanisms driving metastasis.
Michael P, Marciel, Peter R, Hoffmann
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