Results 131 to 140 of about 1,328,750 (347)

Is it morally permissible to eat meat? [PDF]

open access: yes
Many approaches have been taken regarding this topic, some of them are anthropological or scientific that pursue the understanding of why we eat meat, but from the philosophical lens this question is solved in the field of applied ethics, which is the ...
Diez De Fex, Ana Maria
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

STUDIES ON BIOCHEMICAL CHANGES AND THERAPEUTIC MANAGEMENT OF METABOLIC SYNDROME IN DOGS [PDF]

open access: yesJournal of Veterinary and Animal Sciences, 2017
Twelve obese dogs with metabolic syndrome were treated with ezetimibe @ 0.1mg/ kg bodyweight for a period of 30 days.
Siji.S.Raj   +5 more
doaj  

Towards a coherent theory of animal equality [PDF]

open access: yes, 2014
In this article I want to construct in a simple and systematic way an ethical theory of animal equality. The goal is a consistent theory, containing a set of clear and coherent universalized ethical principles that best fits our strongest moral ...
Bruers, Stijn
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Neither light nor language [PDF]

open access: yes, 2014
This paper takes the context of responding to the film, Dark Light (2014) by Maria O’Connor, as a provocation to engage with aspects of the work of Jacques Derrida on the animal and the human. Dark Light develops as an essay film that references a series
Jackson, ML
core  

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

open access: yesFEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner   +6 more
wiley   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

open access: yesFEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp   +13 more
wiley   +1 more source

Animal Ethics and Animal Consciousness

open access: yesAnimal Behavior and Cognition, 2017
Bernard E. Rollin
doaj   +1 more source

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