Results 111 to 120 of about 1,347,369 (302)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Going veg: care of the animals or care of the self? [PDF]
, 2017 Mainstream animal ethics theories, such as Singer’s and Regan’s, argue in favor of dietary behaviors excluding at all animal derived products. According to those accounts, in our societies and in our present conditions of life discarding food obtained ...
Pollo, S.
core
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
HAEMATOBIOCHEMICAL CHANGES ASSOCIATED WITH CUTANEOUS VASCULITIS IN DOGS [PDF]
Journal of Veterinary and Animal Sciences, 2019 The present study documents the haematological and serum biochemical parameters in cutaneous vasculitis in dogs. Cutaneous vasculitis is the inflammation of blood vessels of dermis and subcutaneous tissue.
G.R. Chaitra +4 more
doaj
A call to implement preclinical study registration in animal ethics review. [PDF]
PLoS Biol, 2023 Jeffers MS +6 more
europepmc +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Reflective Empiricism and Empirical Animal Ethics. [PDF]
Animals (Basel), 2022 Winther H.
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
What Is Wrong with Eating Pets? Wittgensteinian Animal Ethics and Its Need for Empirical Data. [PDF]
Animals (Basel), 2023 Linder E, Grimm H.
europepmc +1 more source