Results 51 to 60 of about 1,347,369 (302)

Real‐World Pediatric Blinatumomab Administration: Access to Outpatient Care Delivery and Impact of a Hospital‐Dispensed Model

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Blinatumomab has been shown to be highly effective for patients with pediatric B‐ALL and has recently become standard of care therapy. Due to its past use in the clinical trial setting, there is limited information available about real‐world administration.
Katelyn Oranges, Kelly A. Duffy, Sara McDonough, Evelyn Kurpiewski, R. Jennifer Randall, Allison Barz Leahy, Haley M. Newman, Joyce P. Lee, Stephen P. Hunger, Anne F. Reilly, David T. Teachey, Susan R. Rheingold, Daniel J. Zheng   +12 more
wiley   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

For Hierarchy in Animal Ethics [PDF]

, 2018
In my forthcoming book, How to Count Animals, More or Less (based on my 2016 Uehiro Lectures in Practical Ethics), I argue for a hierarchical approach to animal ethics according to which animals have moral standing but nonetheless have a lower moral ...
Kagan, Shelly
core  

Inpatient Food Insecurity and Pediatric Hematology Oncology Hospitalization Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Children with cancer and blood disorders are at risk for food insecurity (FI). We aimed to describe the association of inpatient food insecurity (IFI) and hospitalization outcomes among patients admitted to the pediatric hematology oncology service. Of 325 caregivers screened for IFI, 60 (18.6%) screened positive.
Joanna M. Robles, Greg Russell, Leila H. DeWitt, Kimberly Montez, Callie L. Brown   +4 more
wiley   +1 more source

Ethics, space, and somatic sensibilities: comparing relationships between scientific researchers and their human and animal experimental subjects [PDF]

, 2011
Drawing on geographies of affect and nature-society relations, we propose a radical rethinking of how scientists, social scientists, and regulatory agencies conceptualise human and animal participants in scientif ic research. The scientific rationale for
Birke L, Boo M J, Buchanan-Smith H M, Butler R, Calarco M, Ehni H, FAWC, Fenwick N P, Grandin T, Grosz E, Haraway D, Harlow H, Hinchliffe S, Jones O, Katz J, Keller E F, Latour B, Lawler J, Leach M, Lorimer J, Nast H J, Paterson M, RCN, RCN, Roe E, Rudge T, Russell W M S, Singer P, Stengers I, Thrift N, Vorstenbosch J M C, Wemelsfelder F, Whatmore S, Wolfe C   +33 more
core   +1 more source

Germline TP53 Mutations Causing Diamond–Blackfan Anemia: A French Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Diamond–Blackfan anemia is a rare congenital erythroblastopenia typically caused by mutations in ribosomal protein genes. Recently, gain‐of‐function mutations in TP53 have been identified as a novel cause of Diamond–Blackfan anemia. We report two French patients who both harbored a heterozygous TP53 deletion (NM_000546.5: c.1077delA; p ...
Rafael Moisan, Lydie Da Costa, Ludivine David Nguyen, Heloise Chosseler, Audrey Riquet, Benedicte Bruno, Melissa Barbati   +6 more
wiley   +1 more source

Conceptual foundations for a clarified meaning of the 3Rs principles in animal experimentation

Animal Welfare
Russell and Burch’s 1959 original definitions of the 3Rs (replacement, reduction and refinement) are widely used today as standards for the ethical use of non-human animals in research, although they have a number of limitations. Authors and institutions
Edwin Louis-Maerten, Christian Rodriguez Perez, Rosa Maria Cajiga, Kirsten Persson, Bernice Simone Elger   +4 more
doaj   +1 more source

Nouvelles convergences entre éthique environnementale et éthique animale : vers une éthique climatique non anthropocentriste

VertigO, 2020
This article investigates new convergences between animal ethics and environmental ethics by focusing on the effects as well as the causes of climate change.
Michel Bourban , Lisa Broussois 
doaj   +1 more source

Two Views of Animals in Environmental Ethics [PDF]

, 2016
This chapter concerns the role accorded to animals in the theories of the English-speaking philosophers who created the field of environmental ethics in the latter half of the twentieth century.
Gary, Comstock
core  

An insufferable business : ethics, nonhuman animals and biomedical experiments [PDF]

, 2015
Each year millions of nonhuman animals suffer in biomedical research for human health benefits. Clinical ethics demand that nonhuman animals are used in the development of pharmaceuticals and vaccines.
Peggs, Kay
core   +2 more sources