Results 71 to 80 of about 1,328,750 (347)

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Levinasian Ethics and Animal Rights

The Windsor Yearbook of Access to Justice, 2008
What can we say, in good faith, about the moral status of animals? This article explores the above question through the prism of Emmanuel Levinas’ theory of ethics. I begin by examining the ambiguous position of non-human animals in Levinas’ writings.
Jonathan Crowe
doaj   +1 more source

Does organic farming face distinctive livestock welfare issues? - A conceptual analysis [PDF]

, 2001
The recent development and growth of organic livestock farming and the related development of national and international regulations has fuelled discussions among scientists and philosophers concerning the proper conceptualisation of animal welfare ...
Alrøe, Hugo Fjelsted, Kristensen, Erik Steen, Vaarst, Mette   +2 more
core  

A new dawn? The Roman Catholic Church and environmental issues [PDF]

, 1997
This is a PDF version of an article published in New Blackfriars© 1997. The definitive version is available at www.blackwell-synergy.com.This article discusses the stance of the Roman Catholic Church on environmental issues and argues that the Church ...
ACORA, Atkins M., Balthasar H., Clark S., Deane-Drummond C., Deane-Drummond C., Deane-Drummond C., Fox M., Linzey A., McCarthy J., McCarthy J., McDonagh S., Murray R., Sorrell R.D., Stanton H., Zizioulas J.   +15 more
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Animal Ethics and the Political [PDF]

, 2016
Some of the most important contributions to animal ethics over the past decade or so have come from political, as opposed to moral, philosophers. As such, some have argued that there been a ‘political turn’ in the field. If there has been such a turn, it
Adams C., Alasdair Cochrane, Anderson E., Callicott J.B., Cochrane A., Cochrane A., Cohen C., Donaldson S., Donaldson S., Donovan J., Driessen C., Feinberg J., Flanders C., Francione G., Francione G., Francione G., Garner R., Garner R., Hadley J., Hauser M., Hills A., Midgley M., Milburn J., Milligan T., Milligan T., Mills C., Nibert D., Noddings N., Nozick R., Nussbaum M., Palmer C., Rawls J., Rawls J., Regan T., Regan T., Robert Garner, Rollin B., Rollin B., Singer P., Siobhan O’Sullivan, Torres B., Wissenburg M., Woodhall A.   +42 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

PARTIAL SEIZURES IN PUPPIES DUE TO Otodectus cyanotisINFESTATION- A REPORT OF TWO CASES [PDF]

Journal of Veterinary and Animal Sciences, 2017
A seizure is the clinical manifestation of an excessive discharge of hyperexcitable cerebrocortical neurons. Partial seizures have a focal onset in one of the cerebral hemisphere and limited spreading within the brain (Quesnel, 2010).
Deepa Chirayath, K Syamala, Silpa Sasi, T.R. Rajin   +3 more
doaj  

Animal suicide: An account worth giving? Commentary on Peña-Guzmán on Animal Suicide [PDF]

, 2018
Peña-Guzmán (2017) argues that empirical evidence and evolutionary theory compel us to treat the phenomenon of suicide as continuous in the animal kingdom.
Mikhalevich, Irina
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source