Results 121 to 130 of about 1,085,479 (217)

Comment on Walsh P, et al. Lung ultrasound allows for earlier diagnosis of bronchiolitis than auscultation: an animal experiment and human case series. J Ultrasound, 2022. [PDF]

J Ultrasound, 2023
La Regina DP, Petrarca L, Nenna R, Iovine E, Mancino E, Midulla F.   +5 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Copper and cuproptosis-related genes as indictors for the diagnosis of injury time in traumatic brain injury: human cases and animal experiment. [PDF]

Front Cell Neurosci
Gu R, Yu X, Tan Y, Li G, Suo L, Ding R, Yao H.   +6 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Relationship between plasma atherogenic index and subclinical hypothyroidism: an analysis of NHANES data and animal experiment. [PDF]

Front Endocrinol (Lausanne)
Chen Q, Li Y, Ruan Y, Jin L, Yao S, Han Z, Hong X, Wang Z, Li L, He W, Yang L, Heng X.   +11 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Utilization of animal experiment-based simulation surgery platforms in the education of endoscopic thyroidectomy: a preliminary study. [PDF]

BMC Med Educ
Yan H, Zhu R, Yue N, Han Z, Yu X, Tanu C, Wang P, Yu X.   +7 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Animal experiment on osseointegration of porous titanium root analogue implants with composite CSn-TAK242 coating. [PDF]

Front Bioeng Biotechnol
Li H, Luo D, Gao Y, Wang D, Yang J, Xu Z.   +5 more
europepmc   +1 more source

Research of Importance of Thiol, CRP and Lactate in Diagnosing Mesenteric Ischemia At An Early Stage: Animal Model. [PDF]

Ulus Travma Acil Cerrahi Derg, 2023
Canlıkarakaya F, Yüksel BC, Er S, Keçelioğlu Y, Neselioglu S.   +4 more
europepmc   +1 more source