Results 31 to 40 of about 344,168 (253)
miRNA‐29 regulates epidermal and mesenchymal functions in skin repair
FEBS Letters, EarlyView.miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan +10 more
wiley +1 more source
Killing and Feeling Bad: Animal Experimentation and Moral Stress [PDF]
, 2016 This paper is prompted by the introspective account of animal experimentation provided by Marks in his paper ‘Killing Schrödinger’s Feral Cat’ in this journal. I offer an ethical interpretation of Marks\u27 paper, and add personal reflections based on my
King, Mike R
core +1 more source
Importance of animal experimentation in gynecology and obstetrics [PDF]
, 2011 Universidade de São Paulo faculdade de Medicina Departamento de Obstetrícia e GinecologiaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de ObstetríciaUNIFESP, EPM, Depto.
BARACAT, Edmund Chada +2 more
core +2 more sources
FEBS Letters, EarlyView.Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez +3 more
wiley +1 more source
HRC Research Primer: Animal Experimentation [PDF]
, 2008 The number of animals used in medical, pharmaceutical, and product research each year is at least 115 million worldwide, using official figures. The actual number is believed to be much higher. Generally speaking, most people surveyed in the U.S.
core
FEBS Letters, EarlyView.We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring +6 more
wiley +1 more source
Animal Experimentation: Working Towards a Paradigm Change [PDF]
, 2019 Animal experimentation has been one of the most controversial areas of animal use, mainly due to the intentional harms inflicted upon animals for the sake of hoped-for benefits in humans.
Herrmann, Kathrin, (ed.) +1 more
core +1 more source
Universal and unique features of kinesin motors: Insights from a comparison of fungal and animal conventional kinesins [PDF]
, 1999 Kinesins are microtubule motors that use the energy derived from the hydrolysis of ATP to move unidirectionally along microtubules, The founding member of this still growing superfamily is conventional kinesin, a dimeric motor that moves processively ...
Hackney D.D. +5 more
core +1 more source
FEBS Letters, EarlyView.Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke +2 more
wiley +1 more source
Animal Experimentation in Research: Statement on the Transposition of EU Directive 2010/63 into German Law [PDF]
, 2012 The present Statement not only describes the ethical bases and the legal framework for animal experimentation research, but also focuses on the broader field of biological and medical research from various perspectives.
Deutsche Akademie der Naturforscher Leopoldina +1 more
core +1 more source