Results 91 to 100 of about 965,579 (357)

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

open access: yesAdvanced Biology, EarlyView.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li   +10 more
wiley   +1 more source

Validation and Improvement of the Beef Production Sub-index in Ireland for Beef Cattle [PDF]

open access: yes, 2009
End of project reportThe objectives of the following study were to: a. Quantify the effect of sire genetic merit for BCI on: 1. feed intake, growth and carcass traits of progeny managed under bull or steer beef production systems. 2.
Berry, Donagh   +5 more
core  

HMGB1 Derived from the Pyroptotic Microenvironment Promotes Macrophage Extracellular Traps in Hirschsprung‐Associated Enterocolitis

open access: yesAdvanced Biology, EarlyView.
HMGB1 derived from the pyroptotic environment in Hirschsprung‐associated enterocolitis mediates the formation of macrophage extracellular traps through TLR4 ‐p38 MAPK/p65 NF‐kB signaling pathways. Macrophage extracellular traps induce increased ROS production and pyroptosis of colonic epithelial cells.
Rui Zhang   +6 more
wiley   +1 more source

Fermented liquid feed for pigs [PDF]

open access: yes, 2010
Since the announcement of the ban on the use of antibiotics as antimicrobial growth promoters in the feed of pigs in 2006 the investigation towards alternative feed additives has augmented considerably.
De Smet, Stefaan   +4 more
core   +2 more sources

Bridging Nature and Technology: A Perspective on Role of Machine Learning in Bioinspired Ceramics

open access: yesAdvanced Engineering Materials, EarlyView.
Machine learning (ML) is revolutionizing the development of bioinspired ceramics. This article investigates how ML can be used to design new ceramic materials with exceptional performance, inspired by the structures found in nature. The research highlights how ML can predict material properties, optimize designs, and create advanced models to unlock a ...
Hamidreza Yazdani Sarvestani   +2 more
wiley   +1 more source

PD-1/PD-L1 axis induced host immunosuppression via PI3K/Akt/mTOR signalling pathway in piglets infected by Glaesserella Parasuis

open access: yesBMC Veterinary Research
Glaesserella parasuis, an important respiratory bacterial pathogen, causes Glässer’s disease in piglets, with potential immunosuppression. We established a piglet infection model and explored the immunosuppression mechanism to improve our understanding ...
Jingyang Li   +13 more
doaj   +1 more source

Microalgae for Biofuels and Animal Feeds [PDF]

open access: yesEnergies, 2013
The potential of microalgae biomass production for low-cost commodities—biofuels and animal feeds—using sunlight and CO2 is reviewed. Microalgae are currently cultivated in relatively small-scale systems, mainly for high value human nutritional products.
openaire   +2 more sources

A Case‐Based Reasoning Approach to Model Manufacturing Constraints for Impact Extrusion

open access: yesAdvanced Engineering Materials, EarlyView.
A hybrid modeling approach is presented that combines constraint‐based process modeling and case‐based reasoning. The model formalizes manufacturing constraints and integrates simulation data to model complex manufacturing processes. The approach supports manufacturability analysis during product design through an adaptive modeling environment.
Kevin Herrmann   +5 more
wiley   +1 more source

The multifaceted role of ferroptosis in infection and injury and its nutritional regulation in pigs

open access: yesJournal of Animal Science and Biotechnology
Ferroptosis is a newly identified form of regulated cell death (RCD) characterized by iron overload and excessive lipid peroxidation. To date, numerous studies in human and mouse models have shown that ferroptosis is closely related to tissue damage and ...
Bei Zhou   +3 more
doaj   +1 more source

Effects of fermented bamboo fiber on intestinal health and fecal pollutants in weaned piglets

open access: yesFrontiers in Nutrition
IntroductionWeaning stress adversely affects piglet growth and development, thereby reducing the economic efficiency of pig farming operations. Furthermore, pig feces are a major source of environmental pollution, underscoring the need for effective ...
Yubiao Jia   +11 more
doaj   +1 more source

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