Results 91 to 100 of about 2,326,634 (293)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Efficiency of different strategies to mitigate ascertainment bias when using SNP panels in diversity studies

BMC Genomics, 2018
Background Single nucleotide polymorphism (SNP) panels have been widely used to study genomic variations within and between populations. Methods of SNP discovery have been a matter of debate for their potential of introducing ascertainment bias, and ...
Dorcus Kholofelo Malomane, Christian Reimer, Steffen Weigend, Annett Weigend, Ahmad Reza Sharifi, Henner Simianer   +5 more
doaj   +1 more source

Genetic modification of food animals [PDF]

Current Opinion in Biotechnology, 2017
Animal breeders have used a variety of methods in selective breeding programs to genetically improve food animal species. Recently this has included the use of both genetic engineering and genome editing, particularly for targeting improvement in traits for which there is no within-species or within-breed genetic variation.
openaire   +2 more sources

Genetic heterogeneity of residual variance - estimation of variance components using double hierarchical generalized linear models [PDF]

, 2010
Background The sensitivity to microenvironmental changes varies among animals and may be under genetic control. It is essential to take this element into account when aiming at breeding robust farm animals.
Erling Strandberg, Rönnegård, Lars, Mulder, Herman A., Felleki Majbritt, Fikse, Freddy, Rönnegård Lars, Majbritt Felleki, Ronnegard, L., Fikse Freddy, Felleki, M., Lars Rönnegård, Freddy Fikse, Herman A Mulder, Strandberg Erling, Mulder, H.A., Strandberg, Erling, Fikse, F., Felleki, Majbritt, Mulder Herman A, Strandberg, E., Rönnegård, Lars,, Felleki, Majbritt,   +21 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Mixture models in quantitative genetics and applications to animal breeding

Revista Brasileira de Zootecnia, 2007
Finite mixture models are helpful for uncovering heterogeneity due to hidden structure; for example, unknown major genes. The first part of this article gives examples and reviews quantitative genetics issues of continuous characters having a finite ...
Daniel Gianola, Paul J. Boettcher, Jørgen Ødegård, Bjørg Heringstad   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Behavioral Genetics and Animal Science

, 2013
Behavior is shaped by both genetics and experience--nature and nurture. This book synthesizes research from behavioral genetics and animal and veterinary science, bridging the gap between these fields.
Per, Jensen,, Dominic, Wright,
core