Results 91 to 100 of about 1,017,023 (300)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Individual Spatial Consistency and Dietary Flexibility in the Migratory Behavior of Northern Gannets Wintering in the Northeast Atlantic

Frontiers in Ecology and Evolution, 2019
Migration is a fundamental behavioral process prevalent among a wide variety of animal taxa. As individuals are increasingly shown to present consistent responses to environmental cues for breeding or foraging, it may be expected that approaches to ...
W. James Grecian, Hannah J. Williams, Hannah J. Williams, Stephen C. Votier, Stuart Bearhop, Ian R. Cleasby, Ian R. Cleasby, David Grémillet, David Grémillet, Keith C. Hamer, Mélanie Le Nuz, Amélie Lescroël, Amélie Lescroël, Jason Newton, Samantha C. Patrick, Richard A. Phillips, Ewan D. Wakefield, Thomas W. Bodey, Thomas W. Bodey   +18 more
doaj   +1 more source

Cucurbitacin E inhibits the Yes‑associated protein signaling pathway and suppresses brain metastasis of human non‑small cell lung cancer in a murine model. [PDF]

, 2019
Human non‑small cell lung cancer (NSCLC) is associated with an extremely poor prognosis especially for the 40% of patients who develop brain metastasis, and few treatment strategies exist.
Hsu, Ping-Chih, Jablons, David M, Liu, Shu, Tian, Bo, Urisman, Anatoly, Wang, Yu-Cheng, Xu, Zhidong, Yang, Cheng-Ta, Yang, Yi-Lin, You, Liang   +9 more
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Captivity alters behaviour but not seasonal brain size change in semi-naturally housed shrews

Royal Society Open Science
Captivity, frequently used in animal research, can profoundly alter brain size, cognitive abilities and activity levels. Critically, persistent exposure to stressors in captive environments can lead to chronic stress and subsequently to a range of health
Cecilia Baldoni, Konstantinos Raptis, Marina Farantouri, Ivan Lenzi, Ka Sing Lim, Myles H. M. Menz, Marion Muturi, Marco Reisert, Maria Alejandra Bedoya Duque, William R. Thomas, Liliana M. Dávalos, John D. Nieland, Dominik von Elverfeldt, Dina K. N. Dechmann   +13 more
doaj   +1 more source

Gaps in modelling animal migration with evolutionary game theory: infection can favour the loss of migration. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2023
Shaw AK, Torstenson M, Craft ME, Binning SA.   +3 more
europepmc   +1 more source

Trends, Determinants and Constraints of Temporary Sheep Migration in Rajasthan — An Economic Analysis [PDF]

The study has analysed the temporary migration of sheep as a response to the demand-supply disequilibrium of fodder and water and has explored its trends, determinants and constraints by using the data collected from rural areas of semi-arid Rajasthan ...
Gupta, D.C., Mann, J.S., Suresh, A.
core   +1 more source

Modelling Vertical Migration:Combined Effects of Environment and Animal [PDF]

, 2011
Vertical migration is one of the most important types of animal migrations, encompassing most zooplankton and many fish species in the world’s ...
Giske, Jarl
core  

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source