Results 51 to 60 of about 1,017,023 (300)

Radiation-induced lung damage promotes breast cancer lung-metastasis through CXCR4 signaling [PDF]

, 2015
Radiotherapy is a mainstay in the postoperative treatment of breast cancer as it reduces the risks of local recurrence and mortality after both conservative surgery and mastectomy.
Bracke, Marc, De Wagter, Carlos, De Wever, Olivier, Descamps, Benedicte, Feys, Lynn, Vanhove, Christian, Veldeman, Liv, Vermeulen, Stefan, Vral, Anne   +8 more
core   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Internet on animals: Wi‐Fi‐enabled devices provide a solution for big data transmission in biologging

Methods in Ecology and Evolution, 2023
Biologging devices are deployed on animals to collect ultra‐fine‐scale movement data that reveal subsecond patterns in locomotion or long‐term patterns in motion and space use.
Timm A. Wild, Martin Wikelski, Stephen Tyndel, Gustavo Alarcón‐Nieto, Barbara C. Klump, Lucy M. Aplin, Mirko Meboldt, Hannah J. Williams   +7 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Overall Dynamic Body Acceleration in Straw-Colored Fruit Bats Increases in Headwinds but Not With Airspeed

Frontiers in Ecology and Evolution, 2019
Atmospheric conditions impact how animals use the aerosphere, and birds and bats should modify their flight to minimize energetic expenditure relative to changing wind conditions.
M. Teague O'Mara, M. Teague O'Mara, M. Teague O'Mara, Anne K. Scharf, Anne K. Scharf, Anne K. Scharf, Jakob Fahr, Jakob Fahr, Michael Abedi-Lartey, Michael Abedi-Lartey, Martin Wikelski, Martin Wikelski, Martin Wikelski, Dina K. N. Dechmann, Dina K. N. Dechmann, Dina K. N. Dechmann, Kamran Safi, Kamran Safi, Kamran Safi   +18 more
doaj   +1 more source

Factors influencing wind turbine avoidance behaviour of a migrating soaring bird

Scientific Reports, 2022
Wind energy production has expanded as an alternative to carbon emitting fossil fuels, but is causing impacts on wildlife that need to be addressed. Soaring birds show concerning rates of collision with turbine rotor blades and losses of critical habitat.
Carlos D. Santos, Hariprasath Ramesh, Rafael Ferraz, Aldina M. A. Franco, Martin Wikelski   +4 more
doaj   +1 more source

Circadian and Seasonal Patterns of Body Temperature in Arctic Migratory and Temperate Non-migratory Geese

Frontiers in Ecology and Evolution, 2021
Arctic migration presents unique challenges to circadian physiology. In addition to the metabolic cost of maintaining a relatively high body temperature (Tb) above ambient temperature, migratory birds are also exposed to rapidly changing light conditions
Götz Eichhorn, Götz Eichhorn, Götz Eichhorn, Michiel P. Boom, Michiel P. Boom, Henk P. van der Jeugd, Amerins Mulder, Martin Wikelski, Martin Wikelski, Shane K. Maloney, Grace H. Goh   +10 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Determinants of rural household income diversification in Senegal and Kenya [PDF]

, 2012
This paper investigates the determinants of income diversification using data on rural farm households from two Sub-Saharan African countries; Senegal and Kenya. Data were analyzed using regression techniques.
Alobo, Sarah
core