Results 211 to 220 of about 27,577,089 (399)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Author Correction: The RalGAPα1–RalA signal module protects cardiac function through regulating calcium homeostasis

Nature Communications, 2022
Sangsang Zhu, Chao Quan, Ruizhen Wang, Derong Liang, Shu Su, Ping Rong, Kun Zhou, Xinyu Yang, Qiaoli Chen, Min Li, Qian Du, Jingzi Zhang, Lei Fang, Hong-Yu Wang, Shuai Chen   +14 more
doaj   +1 more source

Antidepressant-like effects of extinction learning as an animal model of behavioral therapy. [PDF]

Mol Psychiatry
Liu J, Bulin SE, Morilak DA.
europepmc   +1 more source

Neurogenesis-Dependent and -Independent Effects of Fluoxetine in an Animal Model of Anxiety/Depression

Neuron, 2009
D. David, B. Samuels, Q. Rainer, Jing-wen Wang, D. Marsteller, Indira Mendez, M. Drew, Douglas A. Craig, B. Guiard, J. Guilloux, R. Artymyshyn, A. Gardier, C. Gerald, I. Antonijevic, E. D. Leonardo, R. Hen   +15 more
semanticscholar   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Correction: Characterization of the role of the antioxidant proteins metallothioneins 1 and 2 in an animal model of Alzheimer's disease. [PDF]

Cell Mol Life Sci
Manso Y, Carrasco J, Comes G, Adlard PA, Bush AI, Hidalgo J.   +5 more
europepmc   +2 more sources

Octodon degus: a natural animal model of aging and Alzheimer's disease. [PDF]

Lab Anim (NY)
Hurley MJ, Garduño BM, Deacon RMJ, Holmes TC, Xu X, Cogram P.   +5 more
europepmc   +1 more source

Animal Models

, 2019
Maximino, Caio, Arndt, S.S., van der Staay, F.J.   +2 more
openaire   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Key refinements to a large animal model for measurement of real-time lymphatic transport. [PDF]

BMC Med Imaging
Fanning JE, Bustos V, Jang P, Ser J, Kim E, Kinney J, Yamashita A, Choi HS, Singhal D.   +8 more
europepmc   +1 more source