Results 211 to 220 of about 25,135,144 (317)

Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis

FEBS Open Bio, EarlyView.
Statins, identified via the Comparative Toxicogenomics Database, promote monocytic differentiation and apoptosis in non‐APL AML cells by upregulating DPYSL2A through a KLF4‐dependent pathway. Mevalonate supplementation reversed these effects, indicating involvement of the mevalonate pathway.
Mina Noura, Kota Shoji, Michidai Nobe, Moe Ishikawa, Miu Tanaka, Akiko Okayama, Souichi Adachi, Hidemasa Matsuo   +7 more
wiley   +1 more source

Reproductive Dysfunction in Experimental Autoimmune Encephalomyelitis, an Animal Model of Multiple Sclerosis. [PDF]

Exp Neurobiol
Shin T, Kim SJ, Kang T, Jeong H, Ahn M, Jung K, Kim J.   +6 more
europepmc   +1 more source

Therapeutic implication of pharmacological evidences of excitatory dysregulation in animal models of ASD

, 2019
Chan Young Shin
openalex   +1 more source

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, EarlyView.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source

Local surgical trauma in the penile tunica albuginea of the rat: a new animal model of Peyronie's disease. [PDF]

Sex Med
Li Z, Hu H, Zheng X, Liu B, Zhao L, Han Z, Zhou Z, Xu J, Yin Y, Tang Y.   +9 more
europepmc   +1 more source

Key role for inhibins in effective T cell activation, migration and Th17 differentiation

FEBS Open Bio, EarlyView.
Activins/inhibins modulate immune responses. Here, we show that inhibins can be produced very early after T cell activation and can act in an autocrine way, favoring Th1 versus Th17 differentiation and CCL19/CCL21 mediated migration. Recombinant inhibin A can restore the Th1/Th17 balance, highlighting the role of inhibins as key regulators of T cell ...
Sandra Ortega‐Francisco, Roxana Olguín‐Alor, Lizbeth Bolaños‐Castro, Alexandra Morales‐Cruz, Marisol De La Fuente‐Granada, Gloria Soldevila   +5 more
wiley   +1 more source

Cortical Stimulation-Based Transcriptome Shifts on Parkinson's Disease Animal Model. [PDF]

ASN Neuro
Nam J, Shin H, You C, Baeg E, Kim JG, Yang S, Han MR.   +6 more
europepmc   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

Orexin-A and motion sickness: a systematic review of animal model studies. [PDF]

Front Pharmacol
Cai X, Zhao L, Wang X, Chen J, Yuan Y, Gao B, You Y.   +6 more
europepmc   +1 more source

Rational attenuation of canine distemper virus (CDV) to develop a morbillivirus animal model that mimics measles in humans

Katharina S. Schmitz, Linda J. Rennick, Natasha L. Tilston‐Lunel, Anouskha D. Comvalius, Brigitta M. Laksono, Daryl Geers, Peter van Run, Rory D. de Vries, Rik L. de Swart, W. Paul Duprex   +9 more
openalex   +1 more source