Results 21 to 30 of about 25,135,144 (317)
The pentose phosphate pathway regulates chronic neuroinflammation and dopaminergic neurodegeneration
Journal of Neuroinflammation, 2019 Background Metabolic dysfunction and neuroinflammation are increasingly implicated in Parkinson’s disease (PD). The pentose phosphate pathway (PPP, a metabolic pathway parallel to glycolysis) converts glucose-6-phosphate into pentoses and generates ...
Dezhen Tu +5 more
doaj +1 more source
204个国家和地区1990‐2019年因空腹血糖升高导致的全球卒中疾病负担:全球疾病负担研究分析
Journal of Diabetes, 2022 Background High fasting plasma glucose (HFPG) is the leading risk factor contributing to the increase of stroke burden in the past three decades. However, the global distribution of stroke burden specifically attributable to HFPG was not studied in depth.
Yang Liu +8 more
doaj +1 more source
Selecting an Appropriate Animal Model of Depression
International Journal of Molecular Sciences, 2019 Depression has become one of the most severe psychiatric disorders and endangers the health of living beings all over the world. In order to explore the molecular mechanism that underlies depression, different kinds of animal models of depression are ...
Yuanzhen Hao +3 more
semanticscholar +1 more source
Role of animal models in biomedical research: a review
Laboratory Animal Research, 2022 The animal model deals with the species other than the human, as it can imitate the disease progression, its’ diagnosis as well as a treatment similar to human.
P. Mukherjee, S. Roy, D. Ghosh, S. Nandi
semanticscholar +1 more source
Combinatorial Control of Recruitment of a Variant PRC1.6 Complex in Embryonic Stem Cells
Cell Reports, 2018 Summary: Though genetic data suggest that Polycomb group proteins (PcGs) are central chromatin modifiers and repressors that have been implicated in control of embryonic stem cell (ESC) pluripotency, the precise mechanism of PcG complex recruitment ...
Yikai Huang +8 more
doaj +1 more source
EBioMedicine, 2020 Background: Alteration of commensal bacterial composition is associated with many inflammatory diseases. However, few studies have pinpointed the specific bacterial genes that may suppress host immune responses against microbes and maintain homeostasis ...
Dayuan Zou +14 more
doaj +1 more source
Syrian Hamster as an Animal Model for the Study on Infectious Diseases
Frontiers in Immunology, 2019 Infectious diseases still remain one of the biggest challenges for human health. In order to gain a better understanding of the pathogenesis of infectious diseases and develop effective diagnostic tools, therapeutic agents, and preventive vaccines, a ...
Jinxin Miao +3 more
semanticscholar +1 more source
Choosing the right animal model for infectious disease research
Animal Models and Experimental Medicine, 2018 A complex biological system is often required to study the myriad of host‐pathogen interactions associated with infectious diseases, especially since the current basis of biology has reached the molecular level.
J. Swearengen
semanticscholar +1 more source
The 2020 Five Domains Model: Including Human–Animal Interactions in Assessments of Animal Welfare
Animals, 2020 Simple Summary This review outlines the latest in a succession of updates of the Five Domains Model, which, at each stage, incorporated contemporary verified scientific thinking of relevance to animal welfare assessment.
D. Mellor +6 more
semanticscholar +1 more source
Zebrafish: A complete animal model to enumerate the nanoparticle toxicity
Journal of Nanobiotechnology, 2016 Presently, nanotechnology is a multi-trillion dollar business sector that covers a wide range of industries, such as medicine, electronics and chemistry.
C. Chakraborty +3 more
semanticscholar +1 more source