PER1 Phosphorylation Specifies Feeding Rhythm in Mice
Cell Reports, 2014 Organization of circadian behavior, physiology, and metabolism is important for human health. An S662G mutation in hPER2 has been linked to familial advanced sleep-phase syndrome (FASPS).
Zhiwei Liu +10 more
doaj +1 more source
Scientific Reports, 2022 The use of minipigs (Sus scrofa) as a platform for toxicological and pharmacological research is well established. In the present study, we investigated the effect of formaldehyde (FA) exposure on helper T cell-mediated splenic immune responses in ...
Jeongsik Park +5 more
doaj +1 more source
Spatiotemporal regulation of insulin signaling by liquid–liquid phase separation
Cell Discovery, 2022 Insulin signals through its receptor to recruit insulin receptor substrates (IRS) and phosphatidylinositol 3-kinase (PI3K) to the plasma membrane for production of phosphatidylinositol-3,4,5-trisphosphate (PIP3) from phosphatidylinositol-4,5-bisphosphate
Kun Zhou +10 more
doaj +1 more source
Probabilistic models of individual and collective animal behavior [PDF]
, 2017 Recent developments in automated tracking allow uninterrupted, high-resolution recording of animal trajectories, sometimes coupled with the identification of stereotyped changes of body pose or other behaviors of interest.
Bodova, Katarina +4 more
core +6 more sources
ACS-20/FATP4 mediates the anti-ageing effect of dietary restriction in C. elegans
Nature Communications, 2023 Dietary restriction is an effective anti-ageing intervention across species. However, the molecular mechanisms from the metabolic aspects of view are still underexplored. Here we show ACS-20 as a key mediator of dietary restriction on healthy ageing from
Zi Wang +12 more
doaj +1 more source
Fundamental Moral Attitudes to Animals and Their Role in Judgment: An Empirical Model to Describe Fundamental Moral Attitudes to Animals and Their Role in Judgment on the Culling of Healthy Animals During an Animal Disease Epidemic [PDF]
, 2009 In this paper, we present and defend the theoretical framework of an empirical model to describe people’s fundamental moral attitudes (FMAs) to animals, the stratification of FMAs in society and the role of FMAs in judgment on the culling of healthy ...
Brom, F.W.A., Cohen, N.E., Stassen, E.N.
core +2 more sources
SLEAP: A deep learning system for multi-animal pose tracking
Nature Methods, 2022 The desire to understand how the brain generates and patterns behavior has driven rapid methodological innovation in tools to quantify natural animal behavior. While advances in deep learning and computer vision have enabled markerless pose estimation in
Talmo D. Pereira +20 more
semanticscholar +1 more source
204个国家和地区1990‐2019年因空腹血糖升高导致的全球卒中疾病负担:全球疾病负担研究分析
Journal of Diabetes, 2022 Background High fasting plasma glucose (HFPG) is the leading risk factor contributing to the increase of stroke burden in the past three decades. However, the global distribution of stroke burden specifically attributable to HFPG was not studied in depth.
Yang Liu +8 more
doaj +1 more source
Selecting an Appropriate Animal Model of Depression
International Journal of Molecular Sciences, 2019 Depression has become one of the most severe psychiatric disorders and endangers the health of living beings all over the world. In order to explore the molecular mechanism that underlies depression, different kinds of animal models of depression are ...
Yuanzhen Hao +3 more
semanticscholar +1 more source
The pentose phosphate pathway regulates chronic neuroinflammation and dopaminergic neurodegeneration
Journal of Neuroinflammation, 2019 Background Metabolic dysfunction and neuroinflammation are increasingly implicated in Parkinson’s disease (PD). The pentose phosphate pathway (PPP, a metabolic pathway parallel to glycolysis) converts glucose-6-phosphate into pentoses and generates ...
Dezhen Tu +5 more
doaj +1 more source