Results 21 to 30 of about 3,851,825 (350)

Spatiotemporal regulation of insulin signaling by liquid–liquid phase separation

Cell Discovery, 2022
Insulin signals through its receptor to recruit insulin receptor substrates (IRS) and phosphatidylinositol 3-kinase (PI3K) to the plasma membrane for production of phosphatidylinositol-3,4,5-trisphosphate (PIP3) from phosphatidylinositol-4,5-bisphosphate
Kun Zhou, Qiaoli Chen, Jiamou Chen, Derong Liang, Weikuan Feng, Minjun Liu, Qi Wang, Ruizhen Wang, Qian Ouyang, Chao Quan, Shuai Chen   +10 more
doaj   +1 more source

Screening and identification of miR-181a-5p in oral squamous cell carcinoma and functional verification in vivo and in vitro

BMC Cancer, 2023
Background Oral squamous cell carcinoma (OSCC) is a common malignant tumor associated with poor prognosis. MicroRNAs (miRNAs) play crucial regulatory roles in the cancer development.
Guoqiang Xu, Yiyan Yang, Junting Yang, Lanfei Xiao, Xiaotang Wang, Litao Qin, Jiping Gao, Ruijing Xuan, Xiaofen Wu, Zhaoyang Chen, Rui Sun, Guohua Song   +11 more
doaj   +1 more source

Probabilistic models of individual and collective animal behavior [PDF]

, 2017
Recent developments in automated tracking allow uninterrupted, high-resolution recording of animal trajectories, sometimes coupled with the identification of stereotyped changes of body pose or other behaviors of interest.
Bodova, Katarina, Harpaz, Roy, Mitchell, Gabriel J., Schneidman, Elad, Tkacik, Gasper   +4 more
core   +6 more sources

The pentose phosphate pathway regulates chronic neuroinflammation and dopaminergic neurodegeneration

Journal of Neuroinflammation, 2019
Background Metabolic dysfunction and neuroinflammation are increasingly implicated in Parkinson’s disease (PD). The pentose phosphate pathway (PPP, a metabolic pathway parallel to glycolysis) converts glucose-6-phosphate into pentoses and generates ...
Dezhen Tu, Yun Gao, Ru Yang, Tian Guan, Jau-Shyong Hong, Hui-Ming Gao   +5 more
doaj   +1 more source

204个国家和地区1990‐2019年因空腹血糖升高导致的全球卒中疾病负担:全球疾病负担研究分析

Journal of Diabetes, 2022
Background High fasting plasma glucose (HFPG) is the leading risk factor contributing to the increase of stroke burden in the past three decades. However, the global distribution of stroke burden specifically attributable to HFPG was not studied in depth.
Yang Liu, Wenxin Wang, Xuewei Huang, Xingyuan Zhang, Lijin Lin, Juan‐Juan Qin, Fang Lei, Jingjing Cai, Bo Cheng   +8 more
doaj   +1 more source

Combinatorial Control of Recruitment of a Variant PRC1.6 Complex in Embryonic Stem Cells

Cell Reports, 2018
Summary: Though genetic data suggest that Polycomb group proteins (PcGs) are central chromatin modifiers and repressors that have been implicated in control of embryonic stem cell (ESC) pluripotency, the precise mechanism of PcG complex recruitment ...
Yikai Huang, Wukui Zhao, Congcong Wang, Yaru Zhu, Mengjie Liu, Huan Tong, Yin Xia, Qing Jiang, Jinzhong Qin   +8 more
doaj   +1 more source

A SNP of bacterial blc disturbs gut lysophospholipid homeostasis and induces inflammation through epithelial barrier disruption

EBioMedicine, 2020
Background: Alteration of commensal bacterial composition is associated with many inflammatory diseases. However, few studies have pinpointed the specific bacterial genes that may suppress host immune responses against microbes and maintain homeostasis ...
Dayuan Zou, Jingwen Pei, Jianfeng Lan, Hong Sang, Hongjuan Chen, Haoliang Yuan, Di Wu, Yuanyuan Zhang, Yufang Wang, Dingyu Wang, Yujie Zou, Di Chen, Jianan Ren, Xiang Gao, Zhaoyu Lin   +14 more
doaj   +1 more source

Collective Animal Behavior from Bayesian Estimation and Probability Matching [PDF]

, 2011
Animals living in groups make movement decisions that depend, among other factors, on social interactions with other group members. Our present understanding of social rules in animal collectives is based on empirical fits to observations and we lack ...
A Houston, A Oaten, AC Courville, AJ King, AJW Ward, AJW Ward, Alfonso Pérez-Escudero, B Doligez, C Clark, CAH Bousquet, CJ Proctor, D Alais, DC Knill, DC Knill, DJ Sumpter, DJT Sumpter, DR Wozny, E Mach, ER Behrend, ET Jaynes, G Box, G Rieucau, G Schwarz, Gonzalo G. de Polavieja, H Helmholtz, I Coolen, Iain D. Couzin, ID Couzin, ID Couzin, ID Couzin, ID Couzin, J Alonso, J Neyman, J Staddon, JA Marshall, JB Tenenbaum, JI Gold, JI Gold, JJ Templeton, JJ Templeton, JK Kruschke, JM Biernaskie, JM McNamara, JW Smith, KL Kirk, KP Kording, KP Körding, LA Giraldeau, MO Ernst, N Vulkan, Nordell, PW Battaglia, R Herrnstein, R Jacobs, R Jeanson, RH Wagner, S Blanchet, S Fretwell, SL Lima, SRX Dall, T Boulinier, TJ Valone, TJ Valone, TJ Valone, U Greggers, W Gaissmaier, WA Link, Y Katz, Y van Bergen   +68 more
core   +9 more sources

Animal Models of Dyssynchrony [PDF]

Journal of Cardiovascular Translational Research, 2011
Cardiac resynchronization therapy (CRT) is an important therapy for patients with heart failure and conduction pathology, but the benefits are heterogeneous between patients and approximately a third of patients do not show signs of clinical or echocardiographic response.
Lars B. van Middendorp, Kevin Vernooy, Marc Strik   +2 more
openaire   +2 more sources

Papillomavirus E5: the smallest oncoprotein with many functions [PDF]

, 2011
Papillomaviruses (PVs) are established agents of human and animal cancers. They infect cutaneous and mucous epithelia. High Risk (HR) Human PVs (HPVs) are consistently associated with cancer of the uterine cervix, but are also involved in the ...
Borzacchiello, G., Campo, M.S., Corteggio, A., Nasir, L., Paolini, F., Roperto, S., Venuti, A.   +6 more
core   +4 more sources