Results 21 to 30 of about 26,422,673 (403)

PER1 Phosphorylation Specifies Feeding Rhythm in Mice

open access: yesCell Reports, 2014
Organization of circadian behavior, physiology, and metabolism is important for human health. An S662G mutation in hPER2 has been linked to familial advanced sleep-phase syndrome (FASPS).
Zhiwei Liu   +10 more
doaj   +1 more source

Formaldehyde exposure induces differentiation of regulatory T cells via the NFAT-mediated T cell receptor signalling pathway in Yucatan minipigs

open access: yesScientific Reports, 2022
The use of minipigs (Sus scrofa) as a platform for toxicological and pharmacological research is well established. In the present study, we investigated the effect of formaldehyde (FA) exposure on helper T cell-mediated splenic immune responses in ...
Jeongsik Park   +5 more
doaj   +1 more source

Zebrafish as animal model for aquaculture nutrition research. [PDF]

open access: yes, 2014
The aquaculture industry continues to promote the diversification of ingredients used in aquafeed in order to achieve a more sustainable aquaculture production system. The evaluation of large numbers of diets in aquaculture species is costly and requires
Feijoo, Carmen G   +2 more
core   +2 more sources

Animal Models in Osteosarcoma [PDF]

open access: yesFrontiers in Oncology, 2014
Osteosarcoma (OS) is the most common non-hematologic primary tumor of bone in children and adults. High-dose cytotoxic chemotherapy and surgical resection have improved prognosis, with long-term survival for non-metastatic disease approaching 70%. However, most OS tumors are high grade and tend to rapidly develop pulmonary metastases.
C. Parker Gibbs   +2 more
openaire   +4 more sources

ACS-20/FATP4 mediates the anti-ageing effect of dietary restriction in C. elegans

open access: yesNature Communications, 2023
Dietary restriction is an effective anti-ageing intervention across species. However, the molecular mechanisms from the metabolic aspects of view are still underexplored. Here we show ACS-20 as a key mediator of dietary restriction on healthy ageing from
Zi Wang   +12 more
doaj   +1 more source

Myocardial Dysfunction in an Animal Model of Cancer Cachexia [PDF]

open access: yes, 2011
Aims Fatigue is a common occurrence in cancer patients regardless of tumor type or anti-tumor therapies and is an especially problematic symptom in persons with incurable tumor disease.
Crawford, Danielle   +7 more
core   +2 more sources

Spatiotemporal regulation of insulin signaling by liquid–liquid phase separation

open access: yesCell Discovery, 2022
Insulin signals through its receptor to recruit insulin receptor substrates (IRS) and phosphatidylinositol 3-kinase (PI3K) to the plasma membrane for production of phosphatidylinositol-3,4,5-trisphosphate (PIP3) from phosphatidylinositol-4,5-bisphosphate
Kun Zhou   +10 more
doaj   +1 more source

Using accelerometer, high sample rate GPS and magnetometer data to develop a cattle movement and behaviour model [PDF]

open access: yes, 2009
The study described in this paper developed a model of animal movement, which explicitly recognised each individual as the central unit of measure. The model was developed by learning from a real dataset that measured and calculated, for individual cows ...
Bishop-Hurley, Greg   +5 more
core   +3 more sources

204个国家和地区1990‐2019年因空腹血糖升高导致的全球卒中疾病负担:全球疾病负担研究分析

open access: yesJournal of Diabetes, 2022
Background High fasting plasma glucose (HFPG) is the leading risk factor contributing to the increase of stroke burden in the past three decades. However, the global distribution of stroke burden specifically attributable to HFPG was not studied in depth.
Yang Liu   +8 more
doaj   +1 more source

Animal spirits and credit cycles [PDF]

open access: yes, 2015
In this paper we extend the behavioral macroeconomic model as proposed by De Grauwe (2012) to include a banking sector. The behavioral model takes the view that agents have limited cognitive abilities.
De Grauwe, P, Macchiarelli, C
core   +1 more source

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