Results 81 to 90 of about 3,851,825 (350)
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
Generation of rat offspring from ovarian oocytes by xenotransplantation
Scientific ReportsThe idea of utilizing unused oocytes present in the ovaries has been tested in various ways to produce offspring. However, only a limited number of studies succeeded in offspring generation.
Hiroaki Taketsuru +6 more
doaj +1 more source
Gene regulatory networks that control the specification of neural-crest cells in the lamprey [PDF]
, 2009 The lamprey is the only basal vertebrate in which large-scale gene perturbation analyses are feasible at present. Studies on this unique animal model promise to contribute both to the understanding of the basic neural-crest gene regulatory network ...
Bronner-Fraser, Marianne +1 more
core +1 more source
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Loss of endothelial EMCN drives tumor lung metastasis through the premetastatic niche
Journal of Translational Medicine, 2022 Background Metastasis is the primary cause of cancer-related mortality. Metastasis involves a complex multistep process during which individual tumor cells spread primarily through destruction of the endothelial barrier, entering the circulatory system ...
Guoxin Zhang +5 more
doaj +1 more source
Modelling the Effect of Dorsal Raphe Serotonin Neurons on Patience for Future Rewards [PDF]
, 2016 Serotonin is a neurotransmitter that is implicated in many basic human functions and behaviours and is closely associated with happiness, depression and reward processing.
Porr, Bernd, Sutherland, Marc
core +1 more source
Chinese Medical Journal, 2019 Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease of human beings characterized by not fully reversible airflow limitation. Emphysema is the main pathological feature of COPD which causes high mortality worldwide every year and consumes a large amount of medical expenses. This paper was to review the establishment and
Gui-Bin Liang, Zhi-Hui He, Xin Chen
openaire +4 more sources
Endocrine-Related Cancer, 2017 Animal models of cancer have been instrumental in advancing our understanding of the biology of tumor initiation and progression, in studying gene function and in performing preclinical studies aimed at testing novel therapies. Several animal models of the MEN1 syndrome have been generated in different organisms by introducing loss-of-function ...
Mohr H., Pellegata N. S.
openaire +5 more sources
Purification tags markedly affect self‐aggregation of CPEB3
FEBS Letters, EarlyView.Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito +6 more
wiley +1 more source
Journal of Neuroinflammation, 2020 Background Exposure to benzo(a)pyrene (BaP) was associated with cognitive impairments and some Alzheimer’s disease (AD)-like pathological changes.
Dan Liu +7 more
doaj +1 more source