Results 81 to 90 of about 1,981,363 (314)

A lipidomics study reveals hepatic lipid signatures associating with deficiency of the LDL receptor in a rat model

Biology Open, 2016
The low-density lipoprotein receptor (LDLR) plays a critical role in the liver for the clearance of plasma low-density lipoprotein (LDL). Its deficiency causes hypercholesterolemia in many models.
Hong Yu Wang, Chao Quan, Chunxiu Hu, Bingxian Xie, Yinan Du, Liang Chen, Wei Yang, Liu Yang, Qiaoli Chen, Bin Shen, Bian Hu, Zhihong Zheng, Haibo Zhu, Xingxu Huang, Guowang Xu, Shuai Chen   +15 more
doaj   +1 more source

Neuroprotective Effects of the Lithium Salt of a Novel JNK Inhibitor in an Animal Model of Cerebral Ischemia–Reperfusion [PDF]

, 2022
Igor A. Schepetkin, Г. А. Чернышева, О. И. Алиев, Liliya N. Kirpotina, V. I. Smol’yakova, A. N. Osipenko, М. Б. Плотников, Anastasia R. Kovrizhina, Аndrei I. Khlebnikov, Evgenii Plotnikov, Mark T. Quinn   +10 more
openalex   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

PGC-1α-Coordinated Hypothalamic Antioxidant Defense Is Linked to SP1-LanCL1 Axis during High-Fat-Diet-Induced Obesity in Male Mice

Antioxidants
High-fat-diet (HFD)-induced obesity parallels hypothalamic inflammation and oxidative stress, but the correlations between them are not well-defined. Here, with mouse models targeting the antioxidant gene LanCL1 in the hypothalamus, we demonstrate that ...
Shuai Shi, Jichen Wang, Huan Gong, Xiaohua Huang, Bin Mu, Xiangyu Cheng, Bin Feng, Lanlan Jia, Qihui Luo, Wentao Liu, Zhengli Chen, Chao Huang   +11 more
doaj   +1 more source

Chronic Periodontal Infection and Not Iatrogenic Interference Is the Trigger of Medication-Related Osteonecrosis of the Jaw: Insights from a Large Animal Study (PerioBRONJ Pig Model) [PDF]

, 2023
Matthias Troeltzsch, Stephan Zeiter, Daniel Arens, Dirk Nehrbass, Florian Probst, Paris Liokatis, Michael Ehrenfeld, Sven Otto   +7 more
openalex   +1 more source

Animal models of sepsis [PDF]

Virulence, 2013
Sepsis remains a common, serious, and heterogeneous clinical entity that is difficult to define adequately. Despite its importance as a public health problem, efforts to develop and gain regulatory approval for a specific therapeutic agent for the adjuvant treatment of sepsis have been remarkably unsuccessful.
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Models for character animation

Software Focus, 2001
AbstractGORDON COLLINS and ADRIAN HILTON present a reviewof methods for the constructionand deformation of charactermodels. They consider both stateof the art research and common practice. In particular they review applications, data capture methods, manual model construction, polygonal, parametricand implicit surface representations, basic geometric ...
Collins, G, Hilton, A
openaire   +4 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Transcranial magnetic stimulation in animal models of neurodegeneration

, 2021
Shahid Bashir, Mohammad Uzair, Turki Abualait, Arshad Muhammad, Woo‐Kyoung Yoo, Ali Mir, ReemFahd Bunyan   +6 more
openalex   +1 more source