Results 111 to 120 of about 3,095,140 (302)

Philosophy of Modeling: Neglected Pages of History [PDF]

, 2018
The work done in the philosophy of modeling by Vaihinger (1876), Craik (1943), Rosenblueth and Wiener (1945), Apostel (1960), Minsky (1965), Klaus (1966) and Stachowiak (1973) is still almost completely neglected in the mainstream literature ...
Podnieks, Karlis
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Liver regeneration: unraveling the molecular mechanisms and clinical application

Journal of Translational Medicine
The liver’s exceptional capacity sets it apart from other organs in its response to various acute and chronic injuries, known as “liver regeneration”.
Ning Wang, Meihua Guo, Chu Zhang, Rujiao Jiang, Jianlei Bi, Jie Sun, Bo Liu   +6 more
doaj   +1 more source

A comparative study of Zinc (II) ions removal by a locally produced Granular activated carbon [PDF]

, 2013
Physiochemical properties of wastewater effluent from the plants of a brewery in Lagos, Nigeria were analyzed. The adsorption capacity of Granular activated carbon from animal horns when compared with the available commercial Granulated ...
Aluyor, E. O., Oboh, I. O.
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

GSK-3β at the Intersection of Neuronal Plasticity and Neurodegeneration

Neural Plasticity, 2019
In neurons, Glycogen Synthase Kinase-3β (GSK-3β) has been shown to regulate various critical processes underlying structural and functional synaptic plasticity.
Tomasz Jaworski, Ewa Banach-Kasper, Katarzyna Gralec   +2 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Chromosome-level genome of Cyprinus rubrofuscus ♀ × Sinocyclocheilus grahami ♂ provides high-quality parental haplotype genomes and insights into hybrid economic traits enhancement

BMC Genomics
Cyprinids, the largest and most economically significant family of teleosts, comprise over 600 polyploid species, whose genomic complexity presents challenges in deciphering the genetic basis of phenotypic diversity.
Yanhui Yin, Yuanwei Zhang, Anli Wu, Wei Dao, Jing Long, Xiaofu Pan, Junxing Yang, Xiaoai Wang   +7 more
doaj   +1 more source

Complete Rescue of HTLV-1_p12KO Infectivity by Depletion of Monocytes Together with NK and CD8⁺ T Cells

Pathogens
The transient depletion of monocytes alone prior to exposure of macaques to HTLV-1 enhances both HTLV-1WT (wild type) and HTLV-1p12KO (Orf-1 knockout) infectivity, but seroconversion to either virus is not sustained over time, suggesting a progressive ...
Anna Gutowska, Sarkis Sarkis, Mohammad Arif Rahman, Katherine C. Goldfarbmuren, Ramona Moles, Massimiliano Bissa, Melvin Doster, Robyn Washington-Parks, Katherine McKinnon, Isabela Silva de Castro, Luca Schifanella, Genoveffa Franchini, Cynthia A. Pise-Masison   +12 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source