Results 131 to 140 of about 1,342,535 (334)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Improved order selection method for hidden Markov models: A case study with movement data

Methods in Ecology and Evolution
Hidden Markov models (HMMs) are a versatile statistical framework commonly used in ecology to characterize behavioural patterns from animal movement data.
Fanny Dupont, Marianne Marcoux, Nigel Hussey, Marie Auger‐Méthé   +3 more
doaj   +1 more source

Evaluating wild Turkey movement ecology: An example using first‐passage time analysis

Wildlife Society Bulletin, 2014
Recent advances in animal tracking technology have increased interest in the field of animal movement ecology. Numerous methods have been developed to extract information from animal movement paths that can be used to link movement behavior to external ...
Michael E. Byrne, Joshua D. Guthrie, Jason Hardin, Bret A. Collier, Michael J. Chamberlain   +4 more
doaj   +1 more source

Revisitation analysis uncovers spatio‐temporal patterns in animal movement data [PDF]

, 2018
Chloe Bracis, Keith L. Bildstein, Thomas Mueller   +2 more
openalex   +1 more source

The Movebank system for studying global animal movement and demography [PDF]

, 2021
Roland Kays, Sarah C. Davidson, Matthias Berger, Gil Bohrer, Wolfgang Fiedler, Andrea Flack, Julian Hirt, Clemens Hahn, Dominik Gauggel, B. R. Russell, Andrea Kölzsch, Ashley Lohr, Jesko Partecke, Michael Quetting, Kamran Safi, Anne K. Scharf, Gabriel Schneider, Ilona Lang, Friedrich Schaeuffelhut, Matthias Landwehr, Martin Storhas, Louis van Schalkwyk, Candace M. Vinciguerra, Rolf Weinzierl, Martin Wikelski   +24 more
openalex   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Ponds as experimental arenas for studying animal movement: current research and future prospects. [PDF]

Mov Ecol, 2023
Brönmark C, Hellström G, Baktoft H, Hansson LA, McCallum ES, Nilsson PA, Skov C, Brodin T, Hulthén K.   +8 more
europepmc   +1 more source

Economic Impacts of Restricted Animal Movements in Mexico Due to Increased Mexican Regional Bovine Health Criteria [PDF]

Tuberculosis restrictions on animal movement have important implications for Mexican producers and consumers as well as the U.S. beef cattle industry. The restrictions cause decreased Mexican cattle exports, increased domestic fed beef production, and ...
Cunningham, Megan E., Peel, Derrell S.
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source