Results 91 to 100 of about 10,496,554 (311)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Nutrigenomics in fish: a meta-analysis of the impacts of different feed ingredients on gene expression, feed conversion, and specific growth rate [PDF]

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
This study aimed to describe the impact of diet on gene expression and to quantify, through a meta-analysis, the effect of different ingredients used in nutrigenomic studies on feed conversion and specific growth rates in fish.
L.T.S. Oliveira, A.H.C. Ferreira, K.R.S. Sousa, L.A.S. Figueiredo Filho, F.C.B. Sousa, J.L.R. Sarmento, N.P.S. Santos   +6 more
doaj   +2 more sources

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Dose-dependent effects of selenium (Se)-enriched yeast containing nano-scale Se particles on Se bioavailability, rumen fermentation, hematological profile, and growth performance in female Thin-Tail sheep [PDF]

Veterinary World
Background and Aim: Selenium (Se) deficiency remains a significant nutritional challenge in sheep production due to the limited bioavailability of inorganic Se sources and the low Se availability in many soils and forages.
Dadik Pantaya, Merry Muspita Dyah Utami, Suci Wulandari, Hariadi Subagja, Muhammad Adhyatma, Agus Hadi Prayitno   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Effect of Different Levels of Extruded Coffee (Coffea arabica) Pulp Flour on the Productive Performance and Intestinal Morphometry of Cobb 500 Broiler Chickens

Animals
Coffee pulp is a by-product of the coffee industry. Due to conventional management techniques, it represents a severe environmental problem due to its negative impact on the soil (anaerobic fermentation and pH changes), water sources (the infiltration of
Steven Antúnez, Nadia Fuentes, Marco Gutierrez, Fernando Carcelén, Fritz Trillo, Sofía López, Sandra Bezada, Virginia Rivadeneira, Samuel Pizarro, Jimny Nuñez   +9 more
doaj   +1 more source

Animal Health News

, 2017
This internet resource contains issues published throughout multiple yearsSmall Animal Facilities Seminar Cervid Tuberculosis And Brucellosis Canine Brucellosis Staff Spotlight Dr. Bill Brown Dr.
Kansas Animal Health
core  

Effects of flavonoids extracted from Citrus aurantium on performance, eating and animal behavior, rumen health, and carcass quality in Holstein bulls fed high-concentrate diets [PDF]

, 2018
The effects of flavonoids extracted from Citrus aurantium (Bioflavex® CA) on eating pattern, performance, carcass quality, and rumen wall health of Holstein bulls fed on a single feeder were studied.
Crespo, J., Paniagua, M., Bach, A., Devant, M.   +3 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source