Results 121 to 130 of about 553,501 (299)
Hormone studies on ewes grazing Yarloop clover
, 1971 xviii, 167 [76] leaves : ill.Thesis (Ph.D.) -- University of Adelaide, Dept.
Obst, John Marcus
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
BIOL 451 Animal Physiology Laboratory
, 1987 Course syllabus for BIOL 451 Animal Physiology Laboratory Course description: Covers laboratory experiments and demonstrations associated with Animal Physiology lecture, BIOL ...
Klingensmith, Phyllis M.
core
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Reproductive endocrinology of the viviparous lizard, Tiliqua rugosa
, 1972 xxiii, 171 leaves : ill. + appendixThesis (Ph.D.) -- University of Adelaide, Dept.
Bourne, Anthony Roger
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
iScienceSummary: Micro-computed tomography derived functional biomarkers used in lung disease research can significantly complement end-stage histomorphometric measures while also allowing for longitudinal studies.
Francesca Pennati +7 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Extreme regional heterothermy during flight in diverse wild bats
iScienceSummary: Endotherms actively regulate their body temperatures to maintain relatively constant internal temperatures in heterogeneous environments, but experience regional variation in body temperature (heterothermy). This is especially pronounced in bats,
Andrea D. Rummel +3 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source