Results 1 to 10 of about 4,156,910 (157)

Editorial: Molecular Physiology in Molluscs, Volume II [PDF]

Frontiers in Physiology, 2022
Xuekai Zhang, Youji Wang, Xiaotong Wang
doaj   +4 more sources

Editorial: Integrative Approaches to the Molecular Physiology of Inflammation [PDF]

Frontiers in Physiology, 2018
Enrique Hernández-Lemus, Maria Elena Soto, Carlos Rosales   +2 more
doaj   +4 more sources

TGFβ2 and TGFβ3 mediate appropriate context-dependent phenotype of rat valvular interstitial cells

iScience, 2021
Summary: This study focused on characterizing the potential mechanism of valvular toxicity caused by TGFβ receptor inhibitors (TGFβRis) using rat valvular interstitial cells (VICs) to evaluate early biological responses to TGFβR inhibition. Three TGFβRis
Faye Wang, Cindy Zhang, Jae Kwagh, Brian Strassle, Jinqing Li, Minxue Huang, Yunling Song, Brenda Lehman, Richard Westhouse, Kamalavenkatesh Palanisamy, Vinay K. Holenarsipur, Robert Borzilleri, Karen Augustine-Rauch   +12 more
doaj   +1 more source

Differing impact of phosphoglycerate mutase 1-deficiency on brown and white adipose tissue

iScience, 2022
Summary: Brown adipose tissue (BAT) is a metabolically active organ that contributes to the thermogenic response to cold exposure. In addition, other thermogenic cells termed beige adipocytes are generated in white adipose tissue (WAT) by cold exposure ...
Yohko Yoshida, Ippei Shimizu, Yung-Ting Hsiao, Masayoshi Suda, Goro Katsuumi, Masahide Seki, Yutaka Suzuki, Shujiro Okuda, Tomoyoshi Soga, Tohru Minamino   +9 more
doaj   +1 more source

Protein kinase A activation alleviates cataract formation via increased gap junction intercellular communication

iScience, 2023
Summary: Cataract is the leading cause of blindness worldwide. Here, we reported a potential, effective therapeutic mean for cataract prevention and treatment.
Yu Du, Yuxin Tong, Yumeng Quan, Guangyan Wang, Hongyun Cheng, Sumin Gu, Jean X. Jiang   +6 more
doaj   +1 more source

Impaired interferon-γ signaling promotes the development of silicosis

iScience, 2022
Summary: Silicosis is caused by inhalation of crystalline silica dust particles and known as one of the most serious occupational diseases worldwide. However, little is known about intrinsic factors leading to disease susceptibility.
Zhouyangfan Peng, Mingwu Duan, Yiting Tang, Jianfeng Wu, Kai Zhao, Yanjun Zhong, Zhihui He, Jie Meng, Fangping Chen, Xianzhong Xiao, Haichao Wang, Timothy R. Billiar, Ben Lu, Fang Liang   +13 more
doaj   +1 more source

Activation of GDNF-ERK-Runx1 signaling contributes to P2X3R gene transcription and bone cancer pain

iScience, 2022
Summary: Bone cancer pain is a common symptom in cancer patients with bone metastases and its underlying mechanisms remain unknown. Here, we report that Runx1 directly upregulates the transcriptional activity of P2X3 receptor (P2X3R) gene promoter in ...
Zhu-Lin Yuan, Xiao-Dan Liu, Zi-Xian Zhang, Song Li, Yue Tian, Ke Xi, Jie Cai, Xiao-Mei Yang, Min Liu, Guo-Gang Xing   +9 more
doaj   +1 more source

Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis

iScience, 2021
Summary: Synovial macrophages that are activated by cartilage fragments initiate synovitis, a condition that promotes hypertrophic changes in chondrocytes leading to cartilage degeneration in OA.
Taku Ebata, Mohamad Alaa Terkawi, Masanari Hamasaki, Gen Matsumae, Tomohiro Onodera, Mahmoud Khamis Aly, Shunichi Yokota, Hend Alhasan, Tomohiro Shimizu, Daisuke Takahashi, Kentaro Homan, Ken Kadoya, Norimasa Iwasaki   +12 more
doaj   +1 more source

Renal neoplasms in tuberous sclerosis mice are neurocristopathies

iScience, 2021
Summary: Tuberous sclerosis (TS) is a rare disorder exhibiting multi-systemic benign neoplasms. We hypothesized the origin of TS neoplastic cells derived from the neural crest given the heterogeneous ecto-mesenchymal phenotype of the most common TS ...
Uchenna Unachukwu, Takayuki Shiomi, Monica Goldklang, Kiran Chada, Jeanine D'Armiento   +4 more
doaj   +1 more source

Prominin 1 and Notch regulate ciliary length and dynamics in multiciliated cells of the airway epithelium

iScience, 2022
Summary: Differences in ciliary morphology and dynamics among multiciliated cells of the respiratory tract contribute to efficient mucociliary clearance. Nevertheless, little is known about how these phenotypic differences are established.
Carlos F.H. Serra, Helu Liu, Jun Qian, Munemasa Mori, Jining Lu, Wellington V. Cardoso   +5 more
doaj   +1 more source