Results 11 to 20 of about 1,247,695 (303)

Impaired interferon-γ signaling promotes the development of silicosis

iScience, 2022
Summary: Silicosis is caused by inhalation of crystalline silica dust particles and known as one of the most serious occupational diseases worldwide. However, little is known about intrinsic factors leading to disease susceptibility.
Zhouyangfan Peng, Mingwu Duan, Yiting Tang, Jianfeng Wu, Kai Zhao, Yanjun Zhong, Zhihui He, Jie Meng, Fangping Chen, Xianzhong Xiao, Haichao Wang, Timothy R. Billiar, Ben Lu, Fang Liang   +13 more
doaj   +1 more source

Activation of GDNF-ERK-Runx1 signaling contributes to P2X3R gene transcription and bone cancer pain

iScience, 2022
Summary: Bone cancer pain is a common symptom in cancer patients with bone metastases and its underlying mechanisms remain unknown. Here, we report that Runx1 directly upregulates the transcriptional activity of P2X3 receptor (P2X3R) gene promoter in ...
Zhu-Lin Yuan, Xiao-Dan Liu, Zi-Xian Zhang, Song Li, Yue Tian, Ke Xi, Jie Cai, Xiao-Mei Yang, Min Liu, Guo-Gang Xing   +9 more
doaj   +1 more source

Renal neoplasms in tuberous sclerosis mice are neurocristopathies

iScience, 2021
Summary: Tuberous sclerosis (TS) is a rare disorder exhibiting multi-systemic benign neoplasms. We hypothesized the origin of TS neoplastic cells derived from the neural crest given the heterogeneous ecto-mesenchymal phenotype of the most common TS ...
Uchenna Unachukwu, Takayuki Shiomi, Monica Goldklang, Kiran Chada, Jeanine D'Armiento   +4 more
doaj   +1 more source

Prominin 1 and Notch regulate ciliary length and dynamics in multiciliated cells of the airway epithelium

iScience, 2022
Summary: Differences in ciliary morphology and dynamics among multiciliated cells of the respiratory tract contribute to efficient mucociliary clearance. Nevertheless, little is known about how these phenotypic differences are established.
Carlos F.H. Serra, Helu Liu, Jun Qian, Munemasa Mori, Jining Lu, Wellington V. Cardoso   +5 more
doaj   +1 more source

Alteration of lipid bilayer mechanics by volatile anesthetics: Insights from μs-long molecular dynamics simulations

iScience, 2022
Summary: Very few drugs in clinical practice feature the chemical diversity, narrow therapeutic window, unique route of administration, and reversible cognitive effects of volatile anesthetics.
Eric A. Zizzi, Marco Cavaglià, Jack A. Tuszynski, Marco A. Deriu   +3 more
doaj   +1 more source

A Drosophila platform identifies a novel, personalized therapy for a patient with adenoid cystic carcinoma

iScience, 2021
Summary: Adenoid cystic carcinoma (ACC) is a rare cancer type that originates in the salivary glands. Tumors commonly invade along nerve tracks in the head and neck, making surgery challenging.
Erdem Bangi, Peter Smibert, Andrew V. Uzilov, Alexander G. Teague, Sindhura Gopinath, Yevgeniy Antipin, Rong Chen, Chana Hecht, Nelson Gruszczynski, Wesley J. Yon, Denis Malyshev, Denise Laspina, Isaiah Selkridge, Huan Wang, Jorge Gomez, John Mascarenhas, Aye S. Moe, Chun Yee Lau, Patricia Taik, Chetanya Pandya, Max Sung, Sara Kim, Kendra Yum, Robert Sebra, Michael Donovan, Krzysztof Misiukiewicz, Celina Ang, Eric E. Schadt, Marshall R. Posner, Ross L. Cagan   +29 more
doaj   +1 more source

Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis

iScience, 2021
Summary: Synovial macrophages that are activated by cartilage fragments initiate synovitis, a condition that promotes hypertrophic changes in chondrocytes leading to cartilage degeneration in OA.
Taku Ebata, Mohamad Alaa Terkawi, Masanari Hamasaki, Gen Matsumae, Tomohiro Onodera, Mahmoud Khamis Aly, Shunichi Yokota, Hend Alhasan, Tomohiro Shimizu, Daisuke Takahashi, Kentaro Homan, Ken Kadoya, Norimasa Iwasaki   +12 more
doaj   +1 more source

Celecoxib alleviates pathological cardiac hypertrophy and fibrosis via M1-like macrophage infiltration in neonatal mice

iScience, 2021
Summary: Cardiac hypertrophy is an adaptive response to all forms of heart disease, including hypertension, myocardial infarction, and cardiomyopathy. Cyclooxygenase-2 (COX-2) overexpression results in inflammatory response, cardiac cell apoptosis, and ...
Yanli Zhao, Qi Zheng, Hanchao Gao, Mengtao Cao, Huiyun Wang, Rong Chang, Changchun Zeng   +6 more
doaj   +1 more source

To germinate or not to germinate : a question of dormancy relief not germination stimulation [PDF]

, 2012
A common understanding of the control of germination through dormancy is essential for effective communication between seed scientists whether they are ecologists, physiologists or molecular biologists. Vleeshouwers et al.
Batlla, Bewley, Sanchez, Steven Footitt, William E. Finch-Savage   +4 more
core   +1 more source

Spicy science: David Julius and the discovery of temperature-sensitive TRP channels. [PDF]

, 2015
This invited biographical review covers the career of Dr. David Julius and his discovery of thermosensitive TRP channels. Dr. Julius is currently the Morris Herzstein Chair in Molecular Biology and Medicine and Professor and Chair of Physiology at the ...
Bautista, Diana
core   +2 more sources