Results 21 to 30 of about 642,316 (296)

Protein kinase A activation alleviates cataract formation via increased gap junction intercellular communication

iScience, 2023
Summary: Cataract is the leading cause of blindness worldwide. Here, we reported a potential, effective therapeutic mean for cataract prevention and treatment.
Yu Du, Yuxin Tong, Yumeng Quan, Guangyan Wang, Hongyun Cheng, Sumin Gu, Jean X. Jiang   +6 more
doaj   +1 more source

Impaired interferon-γ signaling promotes the development of silicosis

iScience, 2022
Summary: Silicosis is caused by inhalation of crystalline silica dust particles and known as one of the most serious occupational diseases worldwide. However, little is known about intrinsic factors leading to disease susceptibility.
Zhouyangfan Peng, Mingwu Duan, Yiting Tang, Jianfeng Wu, Kai Zhao, Yanjun Zhong, Zhihui He, Jie Meng, Fangping Chen, Xianzhong Xiao, Haichao Wang, Timothy R. Billiar, Ben Lu, Fang Liang   +13 more
doaj   +1 more source

Activation of GDNF-ERK-Runx1 signaling contributes to P2X3R gene transcription and bone cancer pain

iScience, 2022
Summary: Bone cancer pain is a common symptom in cancer patients with bone metastases and its underlying mechanisms remain unknown. Here, we report that Runx1 directly upregulates the transcriptional activity of P2X3 receptor (P2X3R) gene promoter in ...
Zhu-Lin Yuan, Xiao-Dan Liu, Zi-Xian Zhang, Song Li, Yue Tian, Ke Xi, Jie Cai, Xiao-Mei Yang, Min Liu, Guo-Gang Xing   +9 more
doaj   +1 more source

Renal neoplasms in tuberous sclerosis mice are neurocristopathies

iScience, 2021
Summary: Tuberous sclerosis (TS) is a rare disorder exhibiting multi-systemic benign neoplasms. We hypothesized the origin of TS neoplastic cells derived from the neural crest given the heterogeneous ecto-mesenchymal phenotype of the most common TS ...
Uchenna Unachukwu, Takayuki Shiomi, Monica Goldklang, Kiran Chada, Jeanine D'Armiento   +4 more
doaj   +1 more source

Prominin 1 and Notch regulate ciliary length and dynamics in multiciliated cells of the airway epithelium

iScience, 2022
Summary: Differences in ciliary morphology and dynamics among multiciliated cells of the respiratory tract contribute to efficient mucociliary clearance. Nevertheless, little is known about how these phenotypic differences are established.
Carlos F.H. Serra, Helu Liu, Jun Qian, Munemasa Mori, Jining Lu, Wellington V. Cardoso   +5 more
doaj   +1 more source

Alteration of lipid bilayer mechanics by volatile anesthetics: Insights from μs-long molecular dynamics simulations

iScience, 2022
Summary: Very few drugs in clinical practice feature the chemical diversity, narrow therapeutic window, unique route of administration, and reversible cognitive effects of volatile anesthetics.
Eric A. Zizzi, Marco Cavaglià, Jack A. Tuszynski, Marco A. Deriu   +3 more
doaj   +1 more source

The molecular physiology of CRH neurons. [PDF]

Front Neuroendocrinol, 2012
Corticotropin releasing hormone (CRH) is essential for stress adaptation by mediating hypothalamic-pituitary-adrenal (HPA) axis, behavioral and autonomic responses to stress. Activation of CRH neurons depends on neural afferents from the brain stem and limbic system, leading to sequential CRH release and synthesis.
Aguilera G, Liu Y.
europepmc   +4 more sources

A Drosophila platform identifies a novel, personalized therapy for a patient with adenoid cystic carcinoma

iScience, 2021
Summary: Adenoid cystic carcinoma (ACC) is a rare cancer type that originates in the salivary glands. Tumors commonly invade along nerve tracks in the head and neck, making surgery challenging.
Erdem Bangi, Peter Smibert, Andrew V. Uzilov, Alexander G. Teague, Sindhura Gopinath, Yevgeniy Antipin, Rong Chen, Chana Hecht, Nelson Gruszczynski, Wesley J. Yon, Denis Malyshev, Denise Laspina, Isaiah Selkridge, Huan Wang, Jorge Gomez, John Mascarenhas, Aye S. Moe, Chun Yee Lau, Patricia Taik, Chetanya Pandya, Max Sung, Sara Kim, Kendra Yum, Robert Sebra, Michael Donovan, Krzysztof Misiukiewicz, Celina Ang, Eric E. Schadt, Marshall R. Posner, Ross L. Cagan   +29 more
doaj   +1 more source

The cultivation method affects the transcriptomic response of Aspergillus niger to growth on sugar beet pulp [PDF]

, 2021
In nature, filamentous fungi are exposed to diverse nutritional sources and changes in substrate availability. Conversely, in submerged cultures, mycelia are continuously exposed to the existing substrates, which are depleted over time.
Gelber, Isabelle Benoit, Garrigues, Sandra, Kun, Roland S., P.deVries, Ronald, Mäkelä, Miia, Molecular Plant Physiology, Sub Molecular Plant Physiology, Gruben, Birgit, Kun, Roland, Benoit Gelber, Isabelle, de Vries, Ronald, Peng, Mao, S.Gruben, Birgit   +12 more
core   +1 more source

Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis

iScience, 2021
Summary: Synovial macrophages that are activated by cartilage fragments initiate synovitis, a condition that promotes hypertrophic changes in chondrocytes leading to cartilage degeneration in OA.
Taku Ebata, Mohamad Alaa Terkawi, Masanari Hamasaki, Gen Matsumae, Tomohiro Onodera, Mahmoud Khamis Aly, Shunichi Yokota, Hend Alhasan, Tomohiro Shimizu, Daisuke Takahashi, Kentaro Homan, Ken Kadoya, Norimasa Iwasaki   +12 more
doaj   +1 more source