Results 21 to 30 of about 4,368,802 (298)

Activation of GDNF-ERK-Runx1 signaling contributes to P2X3R gene transcription and bone cancer pain

iScience, 2022
Summary: Bone cancer pain is a common symptom in cancer patients with bone metastases and its underlying mechanisms remain unknown. Here, we report that Runx1 directly upregulates the transcriptional activity of P2X3 receptor (P2X3R) gene promoter in ...
Zhu-Lin Yuan, Xiao-Dan Liu, Zi-Xian Zhang, Song Li, Yue Tian, Ke Xi, Jie Cai, Xiao-Mei Yang, Min Liu, Guo-Gang Xing   +9 more
doaj   +1 more source

Oxytocin promotes hepatic regeneration in elderly mice

iScience, 2021
Summary: Liver aging impairs the ability of hepatocyte regeneration. Recent studies have found that oxytocin (OT) plays an important role in promoting tissue repair and maintaining differentiation and regeneration of stem cells. Here, we reported that OT
Dan Luo, Bin Jin, Xiangyu Zhai, Jing Li, Chuanyong Liu, Wei Guo, Jingxin Li   +6 more
doaj   +1 more source

The birth and development of clinical physiology in Finland [PDF]

, 2022
The specialty of clinical physiology was established in Finland about 20 years later than in Sweden. In the early 1960s, six physicians working mainly in preclinical departments of physiology were certified as specialists in clinical physiology.
Hartiala, Jaakko, Malmberg, Pekka, Sovijarvi, Anssi, Jaakko Hartiala, Pekka Malmberg, Väinö Turjanmaa, Turjanmaa, Väinö, Anssi Sovijärvi, Laitinen, Tomi, Tomi Laitinen, Turjanmaa Väinö, Hartiala Jaakko, Sovijärvi Anssi, Malmberg Pekka, Laitinen Tomi   +14 more
core   +3 more sources

Propionate induces intestinal oxidative stress via Sod2 propionylation in zebrafish

iScience, 2021
Summary: Propionate and propionyl-CoA accumulation have been associated with the development of mitochondrial dysfunction. In this study, we show that propionate induces intestinal damage in zebrafish when fed a high-fat diet (HFD). The intestinal damage
Qianwen Ding, Zhen Zhang, Yu Li, Hongliang Liu, Qiang Hao, Yalin Yang, Einar Ringø, Rolf Erik Olsen, Jihong Liu Clarke, Chao Ran, Zhigang Zhou   +10 more
doaj   +1 more source

Celecoxib alleviates pathological cardiac hypertrophy and fibrosis via M1-like macrophage infiltration in neonatal mice

iScience, 2021
Summary: Cardiac hypertrophy is an adaptive response to all forms of heart disease, including hypertension, myocardial infarction, and cardiomyopathy. Cyclooxygenase-2 (COX-2) overexpression results in inflammatory response, cardiac cell apoptosis, and ...
Yanli Zhao, Qi Zheng, Hanchao Gao, Mengtao Cao, Huiyun Wang, Rong Chang, Changchun Zeng   +6 more
doaj   +1 more source

Molecular Physiology of Mammalian Glucokinase [PDF]

Cellular and Molecular Life Sciences, 2008
The glucokinase (GCK) gene was one of the first candidate genes to be identified as a human "diabetes gene". Subsequently, important advances were made in understanding the impact of GCK in the regulation of glucose metabolism. Structure elucidation by crystallography provided insight into the kinetic properties of GCK.
openaire   +4 more sources

Trace Element Management in Rice

Agronomy, 2015
Trace elements (TEs) are vital for the operation of metabolic pathways that promote growth and structural integrity. Paddy soils are often prone to TE limitation due to intensive cultivation and irrigation practices.
Abin Sebastian, Majeti Narasimha Vara Prasad   +1 more
doaj   +1 more source

NFIA determines the cis-effect of genetic variation on Ucp1 expression in murinethermogenic adipocytes

iScience, 2022
Summary: Thermogenic brown and beige adipocytes counteract obesity by enhancing energy dissipation via uncoupling protein-1 (Ucp1). However, the effect of genetic variation on these cells, a major source of disease susceptibility, has been less well ...
Yuta Hiraike, Shuichi Tsutsumi, Takahito Wada, Misato Oguchi, Kaede Saito, Masahiro Nakamura, Satoshi Ota, Michinori Koebis, Harumi Nakao, Atsu Aiba, Gaku Nagano, Haruya Ohno, Kenji Oki, Masayasu Yoneda, Takashi Kadowaki, Hiroyuki Aburatani, Hironori Waki, Toshimasa Yamauchi   +17 more
doaj   +1 more source

TRPC1 Regulates the Activity of a Voltage-Dependent Nonselective Cation Current in Hippocampal CA1 Neurons

Cells, 2020
The cation channel subunit TRPC1 is strongly expressed in central neurons including neurons in the CA1 region of the hippocampus where it forms complexes with TRPC4 and TRPC5.
Frauke Kepura, Eva Braun, Alexander Dietrich, Tim D. Plant   +3 more
doaj   +1 more source

Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk4

iScience, 2021
Summary: Androgens have a robust effect on skeletal muscles to increase muscle mass and strength. The molecular mechanism of androgen/androgen receptor (AR) action on muscle strength is still not well known, especially for the regulation of sarcomeric ...
Iori Sakakibara, Yuta Yanagihara, Koichi Himori, Takashi Yamada, Hiroshi Sakai, Yuichiro Sawada, Hirotaka Takahashi, Noritaka Saeki, Hiroyuki Hirakawa, Atsushi Yokoyama, So-ichiro Fukada, Tatsuya Sawasaki, Yuuki Imai   +12 more
doaj   +1 more source