Results 1 to 10 of about 511,410 (265)

Adipose triglyceride lipase mediates lipolysis and lipid mobilization in response to iron-mediated negative energy balance

iScience, 2022
Summary: Maintenance of energy balance is essential for overall organismal health. Mammals have evolved complex regulatory mechanisms that control energy intake and expenditure.
Alicia R. Romero, Andre Mu, Janelle S. Ayres   +2 more
doaj   +1 more source

ACSL1 is a key regulator of inflammatory and macrophage foaming induced by short-term palmitate exposure or acute high-fat feeding

iScience, 2023
Summary: Foamy and inflammatory macrophages play pathogenic roles in metabolic disorders. However, the mechanisms that promote foamy and inflammatory macrophage phenotypes under acute-high-fat feeding (AHFF) remain elusive.
Fatema Al-Rashed, Dania Haddad, Ashraf Al Madhoun, Sardar Sindhu, Texy Jacob, Shihab Kochumon, Lina M. Obeid, Fahd Al-Mulla, Yusuf A. Hannun, Rasheed Ahmad   +9 more
doaj   +1 more source

Regulated adipose tissue-specific expression of human AGPAT2 in lipodystrophic Agpat2-null mice results in regeneration of adipose tissue

iScience, 2023
Summary: Genetic loss of Agpat2 in humans and mice results in congenital generalized lipodystrophy with near-total loss of adipose tissue and predisposition to develop insulin resistance, diabetes mellitus, hepatic steatosis, and hypertriglyceridemia ...
Anil K. Agarwal, Katie Tunison, Goncalo Vale, Jeffrey G. McDonald, Xilong Li, Philipp E. Scherer, Jay D. Horton, Abhimanyu Garg   +7 more
doaj   +1 more source

Adipocyte-derived chemerin rescues lipid overload-induced cardiac dysfunction

iScience, 2023
Summary: Chemerin, an adipocyte-secreted protein, has been recently suggested to be linked to metabolic syndrome and cardiac function in obese and diabetes mellitus.
Ruimin Liu, Yinying Han, Chenglong Huang, Mengqian Hou, Rui Cheng, Shujin Wang, Xi Li, Jie Tian   +7 more
doaj   +1 more source

A purinergic mechanism underlying metformin regulation of hyperglycemia

iScience, 2023
Summary: Metformin, created in 1922, has been the first-line therapy for treating type 2 diabetes mellitus for almost 70 years; however, its mechanism of action remains controversial, partly because most prior studies used supratherapeutic concentrations
Jared Senfeld, Qianman Peng, Yi Shi, Shenqi Qian, Jianzhong Shen   +4 more
doaj   +1 more source

Spatially coordinated collective phosphorylation filters spatiotemporal noises for precise circadian timekeeping

iScience, 2023
Summary: The circadian (∼24h) clock is based on a negative-feedback loop centered around the PERIOD protein (PER), translated in the cytoplasm and then enters the nucleus to repress its own transcription at the right time of day.
Seok Joo Chae, Dae Wook Kim, Seunggyu Lee, Jae Kyoung Kim   +3 more
doaj   +1 more source

IL-1beta promotes the age-associated decline of beta cell function

iScience, 2021
Summary: Aging is the prime risk factor for the development of type 2 diabetes. We investigated the role of the interleukin-1 (IL-1) system on insulin secretion in aged mice.
Marianne Böni-Schnetzler, Hélène Méreau, Leila Rachid, Sophia J. Wiedemann, Friederike Schulze, Kelly Trimigliozzi, Daniel T. Meier, Marc Y. Donath   +7 more
doaj   +1 more source

Five‐to‐Seven Carbon Glycols Severely Impair Bioenergetics and Metabolism of Aggressive Lung Cancer Cells

Advanced NanoBiomed Research, 2022
Lung cancer is the leading cause of cancer deaths. Nonsmall cell lung cancer (NSCLC) accounts for the vast majority of the histological subtypes and at advanced stage exhibits extremely low survival rate.
Sílvio Terra Stefanello, Caren Rigon Mizdal, Ihab Azzam, Lilly Döhlinger, Andrea Oeckinghaus, Victor Shahin   +5 more
doaj   +1 more source

In vitro cell models merging circadian rhythms and brain waves for personalized neuromedicine

iScience, 2022
Summary: New evidence is emerging about the dynamics of interaction between circadian rhythms and brain waves, whose coordination occurs through the entrainment process.
Barbara Pavan, Anna Bianchi, Giada Botti
doaj   +1 more source

Pitstop‐2 and its novel derivative RVD‐127 disrupt global cell dynamics and nuclear pores integrity by direct interaction with small GTPases

Bioengineering & Translational Medicine, 2023
Clathrin‐mediated endocytosis (CME) is an essential cell physiological process of broad biomedical relevance. Since the recent introduction of Pitstop‐2 as a potent CME inhibitor, we and others have reported on substantial clathrin‐independent inhibitory
Ivan Liashkovich, Sílvio Terra Stefanello, Reshma Vidyadharan, Günter Haufe, Alexander Erofeev, Peter V. Gorelkin, Vasilii Kolmogorov, Caren Rigon Mizdal, Alexander Dulebo, Etmar Bulk, Ian U. Kouzel, Victor Shahin   +11 more
doaj   +1 more source