The Mitochondrial Ca(2+) Uniporter: Structure, Function, and Pharmacology. [PDF]
, 2017 Mitochondrial Ca(2+) uptake is crucial for an array of cellular functions while an imbalance can elicit cell death. In this chapter, we briefly reviewed the various modes of mitochondrial Ca(2+) uptake and our current understanding of mitochondrial Ca(2+)
A Quintana +167 more
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Piezo1 induces endothelial responses to shear stress via soluble adenylyl Cyclase-IP3R2 circuit
iScience, 2023 Summary: Endothelial cells (ECs) continuously sense and adapt to changes in shear stress generated by blood flow. Here, we show that the activation of the mechanosensitive channel Piezo1 by defined shear forces induces Ca2+ entry into the endoplasmic ...
Dianicha Santana Nunez +8 more
doaj +1 more source
Growth-rate-dependent dynamics of a bacterial genetic oscillator [PDF]
, 2013 Gene networks exhibiting oscillatory dynamics are widespread in biology. The minimal regulatory designs giving rise to oscillations have been implemented synthetically and studied by mathematical modeling.
Lagomarsino, Marco Cosentino +1 more
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Oxidative protein biogenesis and redox regulation in the mitochondrial intermembrane space [PDF]
, 2016 Mitochondria are organelles that play a central role in cellular metabolism, as they are responsible for processes such as iron/sulfur cluster biogenesis, respiration and apoptosis.
MacPherson, Lisa +2 more
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Novel perspectives in redox biology and pathophysiology of failing myocytes: modulation of the intramyocardial redox milieu for therapeutic interventions - A review article from the Working Group of Cardiac Cell Biology, Italian Society of Cardiology [PDF]
, 2016 The prevalence of heart failure (HF) is still increasing worldwide, with enormous human, social, and economic costs, in spite of huge efforts in understanding pathogeneticmechanisms and in developing effective therapies that have transformed this ...
Angelini, Annalisa +8 more
core +9 more sources
Architects of Pituitary Tumour Growth
Frontiers in Endocrinology, 2022 The pituitary is a master gland responsible for the modulation of critical endocrine functions. Pituitary neuroendocrine tumours (PitNETs) display a considerable prevalence of 1/1106, frequently observed as benign solid tumours. PitNETs still represent a
Maria Eugenia Sabatino +5 more
doaj +1 more source
Analysis of DNA-Damage Response to ionizing radiation in serum-shock synchronized human fibroblasts. [PDF]
, 2017 Many aspects of cellular physiology, including cellular response to genotoxic stress, are related to the circadian rhythmicity induced by the molecular clock.
Barbieri, Vito +4 more
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Circadian regulation of reproduction: From gamete to offspring [PDF]
, 2013 P01326625; Grants: GNT0519315Few challenges are more critical to the survival of a species than reproduction. To ensure reproductive success, myriad aspects of physiology and behaviour need to be tightly orchestrated within the animal, as well as timed ...
Boden, M., Kennaway, D., Varcoe, T.
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Journal of Fungi, 2022 Microbial lipids have been a hot topic in the field of metabolic engineering and synthetic biology due to their increased market and important applications in biofuels, oleochemicals, cosmetics, etc. This review first compares the popular hosts for lipid
Wei Jiang +3 more
doaj +1 more source
Nuclear tau and its potential role in Alzheimer’s disease [PDF]
, 2016 Tau protein, found in both neuronal and non-neuronal cells, forms aggregates in neurons that constitutes one of the hallmarks of Alzheimer’s disease (AD).
Al-Hilaly, Youssra +2 more
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