Results 61 to 70 of about 2,084,390 (260)

Inhibition of Sphingolipid Synthesis as a Phenotype-Modifying Therapy in Cystic Fibrosis [PDF]

, 2020
Cystic Fibrosis (CF) is an inherited disease associated with a variety of mutations affecting the CFTR gene. A deletion of phenylalanine 508 (F508) affects more than 70% of patients and results in unfolded proteins accumulation, originating a ...
Bonezzi, Fabiola, Signorelli, Paola, Caretti, Anna, Mingione, Alessandra, Piccoli, Marco, Dei Cas, Michele, Ghidoni, Riccardo, Paroni, Rita, Anastasia, Luigi   +8 more
core   +1 more source

Epidermal growth factor augments the self-renewal capacity of aged hematopoietic stem cells

iScience
Summary: Hematopoietic aging is associated with decreased hematopoietic stem cell (HSC) self-renewal capacity and myeloid skewing. We report that culture of bone marrow (BM) HSCs from aged mice with epidermal growth factor (EGF) suppressed myeloid ...
Vivian Y. Chang, Yuwei He, Samantha Grohe, Morgan R. Brady, Aldi Chan, Rucha S. Kadam, Tiancheng Fang, Amara Pang, Katherine Pohl, Evelyn Tran, Michelle Li, Jenny Kan, Yurun Zhang, Josie J. Lu, Joshua P. Sasine, Heather A. Himburg, Peibin Yue, John P. Chute   +17 more
doaj   +1 more source

The intermediate filament protein nestin serves as a molecular hub for smooth muscle cytoskeletal signaling

Respiratory Research, 2023
Background The recruitment of the actin-regulatory proteins cortactin and profilin-1 (Pfn-1) to the membrane is important for the regulation of actin cytoskeletal reorganization and smooth muscle contraction.
Yinna Wang, Guoning Liao, Yidi Wu, Ruping Wang, Dale D. Tang   +4 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Kinetic analyses of vasculogenesis inform mechanistic studies

, 2017
Vasculogenesis is a complex process by which endothelial stem and progenitor cells undergo de novo vessel formation. Quantitative assessment of vasculogenesis is a central readout of endothelial progenitor cell functionality. However, current assays lack
Dunn, Kenneth W., Winfree, Seth, Tu, Wanzhu, Chu, Chenghao, Blue, Emily K., Gohn, Cassandra R., Haneline, Laura S., Varberg, Kaela M.   +7 more
core   +1 more source

Patient-derived tumor organoids mimic treatment-induced DNA damage response in glioblastoma

iScience
Summary: Glioblastoma (GB) is the most common primary malignant brain tumor, characterized by resistance to therapy. Despite aggressive treatment options, GB remains an incurable disease.
Bernarda Majc, Anamarija Habič, Marta Malavolta, Miloš Vittori, Andrej Porčnik, Roman Bošnjak, Jernej Mlakar, Alenka Matjašič, Andrej Zupan, Marija Skoblar Vidmar, Tamara Lah Turnšek, Aleksander Sadikov, Barbara Breznik, Metka Novak   +13 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Basic cellular physiology

, 2017
This chapter describes basic cellular physiology as it applies to Emergency Medicine, and in particular the Primary FRCEM examination. The chapter outlines the key details of homeostasis, compartments and fluid spaces, cell structure and function, vessel
Mark Harrison
core   +1 more source

Multimodal atlas of single neuron metabolic electrophysiological coupling uncovers circadian rewiring

iScience
Summary: Neuronal metabolism fundamentally modulates synaptic activity, yet how single-cell metabolic architecture aligns with electrophysiological diversity remains elusive.
Man Yuan, Siyuan Ge, Wenwei Qian, Chenjian Miao, Wei Liang, Qi Chen, Hongying Zhu, Wei Xiong   +7 more
doaj   +1 more source