Results 61 to 70 of about 2,176,407 (303)
Enhanced access to the human phosphoproteome with genetically encoded phosphothreonine
Nature Communications, 2022 Protein phosphorylation is a ubiquitous post-translational modification used to regulate cellular processes and proteome architecture by modulating protein-protein interactions.
Jack M. Moen +5 more
doaj +1 more source
iScience, 2023 Summary: The forebrain cholinergic system promotes higher brain function in part by signaling through the M1 muscarinic acetylcholine receptor (mAChR). Long-term potentiation (LTP) and long-term depression (LTD) of excitatory synaptic transmission in the
Tomonari Sumi, Kouji Harada
doaj +1 more source
Physiological and pathological consequences of cellular senescence [PDF]
Cellular and Molecular Life Sciences, 2014 Cellular senescence, a permanent state of cell cycle arrest accompanied by a complex phenotype, is an essential mechanism that limits tumorigenesis and tissue damage. In physiological conditions, senescent cells can be removed by the immune system, facilitating tumor suppression and wound healing.
Dominick G. A. Burton +1 more
openaire +2 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Advances in Physiology EducationUnderstanding cellular physiology, particularly transport across the plasma membrane, remains a significant challenge for undergraduate health sciences students, as these microscopic processes are inherently difficult to visualize.
Ana Carolina de Souza da Rosa +6 more
doaj +1 more source
Respiratory Research, 2023 Background The recruitment of the actin-regulatory proteins cortactin and profilin-1 (Pfn-1) to the membrane is important for the regulation of actin cytoskeletal reorganization and smooth muscle contraction.
Yinna Wang +4 more
doaj +1 more source
Cellular and molecular exercise physiology: talking about past, present and future
, 2020 Exercise physiology has evolved as a main area of investigation, in which the central goal is to better understand how the physiological systems respond to an acute bout of exercise and how these systems adapt to different types of exercise ...
Brum, Patricia Chakur +5 more
core +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
iScienceSummary: Neuronal metabolism fundamentally modulates synaptic activity, yet how single-cell metabolic architecture aligns with electrophysiological diversity remains elusive.
Man Yuan +7 more
doaj +1 more source
Physiological role of the cellular prion protein [PDF]
Veterinary Research, 2007 The prion protein (PrP) plays a key role in the pathogenesis of prion diseases. However, the normal function of the protein remains unclear. The cellular isoform (PrP(C)) is expressed most abundantly in the brain, but has also been detected in other non-neuronal tissues as diverse as lymphoid cells, lung, heart, kidney, gastrointestinal tract, muscle ...
Zomosa-Signoret, Viviana +4 more
openaire +2 more sources