Results 71 to 80 of about 2,084,390 (260)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Exocytosis proteins as novel targets for diabetes prevention and/or remediation?

, 2017
Diabetes remains one of the leading causes of morbidity and mortality worldwide, affecting an estimated 422 million adults. In the US, it is predicted that one in every three children born as of 2000 will suffer from diabetes in their lifetime.
Arianne Aslamy, Debbie C. Thurmond, Aslamy, Arianne, Thurmond, Debbie C.   +3 more
core   +1 more source

Effect of a 3-D cell membrane model combined with an interactive online platform on health students’ learning of cellular physiology

Advances in Physiology Education
Understanding cellular physiology, particularly transport across the plasma membrane, remains a significant challenge for undergraduate health sciences students, as these microscopic processes are inherently difficult to visualize.
Ana Carolina de Souza da Rosa, Giulia Azevedo Martinez, Anna Cecília Perreto, Nelson Gustavo Novais Marinho, Larissa de Almeida Dias, Cláudio Felipe Kolling da Rocha, Pâmela Billig Mello-Carpes   +6 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Rho kinase collaborates with p21-activated kinase to regulate actin polymerization and contraction in airway smooth muscle [PDF]

, 2018
KEY POINTS: The mechanisms by which Rho kinase (ROCK) regulates airway smooth muscle contraction were determined in tracheal smooth muscle tissues.
Bhetwal, Bhupal P., Wenwu Zhang, Zhang, Wenwu, Bhupal P. Bhetwal, Gunst, Susan J., Susan J. Gunst   +5 more
core   +1 more source

Nuclear talin-1 provides a bridge between cell adhesion and gene expression

iScience
Summary: Talin-1 (TLN1) is best known to activate integrin receptors and transmit mechanical stimuli to the actin cytoskeleton at focal adhesions. However, the localization of TLN1 is not restricted to focal adhesions.
Alejandro J. Da Silva, Hendrik S.E. Hästbacka, Mikael C. Puustinen, Jenny C. Pessa, Jens C. Luoto, Erika Sundström, Benjamin T. Goult, Guillaume Jacquemet, Eva Henriksson, Lea Sistonen   +9 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Frontiers in Vascular Physiology _ Speciality Section of Frontiers in Physiology

, 2012
Frontiers in Vascular Physiology is a Specialty Section of Frontiers in Physiology. It is devoted to embracing the field of vascular physiology with all its many facets from the molecular to the intact system level.
ZOCCOLI, GIOVANNA
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Cellular stress responses: cell survival and cell death [PDF]

, 2010
Cells can respond to stress in various ways ranging from the activation of survival pathways to the initiation of cell death that eventually eliminates damaged cells.
Afshin Samali, Hori, Osamu, Gorman, Adrienne M., 26106, Fulda, Simone, 26105, Samali, Afshin, 26107, 60303947, 233, Simone Fulda, Osamu Hori, Adrienne M. Gorman   +12 more
core   +1 more source