Results 81 to 90 of about 2,176,407 (303)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Exploring roles of neuroglobin in oxygen homeostasis and neurodevelopment based on human cerebral organoid models

iScience
Summary: Neuroglobin (NGB) is a neuron-enriched globin known for its neuroprotective role under hypoxic and oxidative stress conditions. However, its function in neurodevelopment remains largely unexplored.
Yuan-Hsuan Liu, Meng-Ting Chung, Hsi-Chieh Lin, Hsin-Lei Lin, Hsuan Lin, Ya-Jen Cheng, Hsiao-Mei Wu, Tzyy-Wen Chiou, Yi-Chung Tung   +8 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Cellular Physiology of Cortical Multisensory Processing.

, 2012
Kayser C, Lakatos P, Meredith M. Cellular Physiology of Cortical Multisensory Processing. In: Stein BE, ed. The New Handbook of Multisensory Processing.
Lakatos, P., Meredith, M., Stein, B.E., Kayser, Christoph ; https://orcid.org/   +3 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Frontiers in Physiology

, 2020
Frontiers in Physiology is a leading journal in its field, publishing rigorously peer-reviewed research on the physiology of living systems, from the subcellular and molecular domains to the intact organism, and its interaction with the ...
Petracci M.
core   +1 more source

Dynamic changes of molecular pattern and cellular subpopulation in puncture-induced tendon injury model

iScience
Summary: Tendon degeneration and injury often result in significant pain and functional impairment. Typically, tendon healing occurs through a scar-mediated response and may progress to chronic tendinopathy without timely intervention.
Zizhan Huang, Ziyang Li, Dengfeng Ruan, Yiwen Xu, Honglu Cai, Hengzhi Liu, Haocheng Jin, Peiwen He, Yang Fei, Jiayun Huang, Canlong Wang, Xiao Chen, Jia Jiang, Weiliang Shen   +13 more
doaj   +1 more source

Physiology in Central and South America and hope for better times

Cellular and Molecular Physiology Laboratory (CMPL) Department of Obstetrics Division of Obstetrics and Gynaecology School of Medicine Faculty of Medicine Pontificia Universidad Católica de ChileDepartment of Physiology Faculty of Pharmacy Universidad de
Sobrevia, Luis [UNESP]
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Nicotinamide mononucleotide restores impaired metabolism, endothelial cell proliferation and angiogenesis in old sedentary male mice

iScience
Summary: Aging is accompanied by a decline in neovascularization potential and increased susceptibility to ischemic injury. Here, we confirm the age-related impaired neovascularization following ischemic leg injury and impaired angiogenesis.
Kevin Kiesworo, Thomas Agius, Michael R. Macarthur, Martine Lambelet, Arnaud Lyon, Jing Zhang, Guillermo Turiel, Zheng Fan, Sènan d’Almeida, Korkut Uygun, Heidi Yeh, Sébastien Déglise, Katrien de Bock, Sarah J. Mitchell, Alejandro Ocampo, Florent Allagnat, Alban Longchamp   +16 more
doaj   +1 more source