Results 91 to 100 of about 2,084,390 (260)

Bridging behavior and physiology: Ion-channel perspective on mushroom body-dependent olfactory learning and memory in Drosophila [PDF]

, 2006
An important body of evidence documents the differential expression of ion channels in brains, suggesting they are essential to endow particular brain structures with specific physiological properties.
Delgado, R, Darszon, A, Labarca, P, Gasque, Gabriel, Gasque, G, Gabriel Gasque, Alberto Darszon, Labarca, Pedro, Darzon, Alberto, Pedro Labarca, Delgado Arriagada, Ricardo, Ricardo Delgado   +11 more
core   +1 more source

Alloxan-induced diabetes exacerbates coronary atherosclerosis and calcification in Ossabaw miniature swine with metabolic syndrome

Journal of Translational Medicine, 2018
Background There is a preponderance of evidence implicating diabetes with increased coronary artery disease (CAD) and calcification (CAC) in human patients with metabolic syndrome (MetS), but the effect of diabetes on CAD severity in animal models ...
Jill K. Badin, Ayeeshik Kole, Benjamin Stivers, Victor Progar, Anisha Pareddy, Mouhamad Alloosh, Michael Sturek   +6 more
doaj   +1 more source

Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-κB/cyclin D1 pathway

Nature Communications, 2020
Pulmonary hypertension is a devastating disease with elevation of pulmonary artery pressure and related to abnormal calcium signalling. Here, the authors show that suppression or stabilization of the calcium channel ryanodine receptor 2 may be a ...
Lin Mei, Yun-Min Zheng, Tengyao Song, Vishal R. Yadav, Leroy C. Joseph, Lillian Truong, Sharath Kandhi, Margarida M. Barroso, Hiroshi Takeshima, Marc A. Judson, Yong-Xiao Wang   +10 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Effect of l-caldesmon on osteoclastogenesis in RANKL-induced RAW264.7 cells

, 2018
Non-muscle caldesmon (l-CaD) is involved in the regulation of actin cytoskeletal remodeling in the podosome formation, but its function in osteoclastogenesis remains to be determined.
劉英明, Chan, Chu-Lung, Renjian Huang, Chih‐Lueh A. Wang, Huang, Renjian, Ying‐Ming Liou, Chu‐Lung Chan, Wang, Chih-Lueh A, Liou, Ying-Ming   +8 more
core   +1 more source

Pathophysiology of Acute Kidney Injury [PDF]

, 2012
Acute kidney injury (AKI) is the leading cause of nephrology consultation and is associated with high mortality rates. The primary causes of AKI include ischemia, hypoxia, or nephrotoxicity.
David P. Basile, Basile, David P., Melissa D. Anderson, Anderson, Melissa D., Timothy A. Sutton, Sutton, Timothy A.   +5 more
core   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Delineation of Molecular Pathways Involved in Cardiomyopathies Caused by Troponin T Mutations* [PDF]

, 2016
Familial hypertrophic cardiomyopathy (FHC) is associated with mild to severe cardiac problems and is the leading cause of sudden death in young people and athletes.
Lai, Xianyin, Gomes, Aldrin V., Gomes, Aldrin V, Witzmann, Frank A., Witzmann, Frank A, Gilda, Jennifer E., Gilda, Jennifer E   +6 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source