Results 111 to 120 of about 2,176,407 (303)

Frontiers in Physiology

Frontiers in Physiology is a field journal of the "Frontiers in" journal series. Physiology investigates the function of all living systems. Frontiers in Physiology publishes tier 1 and tier 2 article types that cover this diverse subject from the ...
CAROSELLI, ERIK
core   +2 more sources

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

The role of the tricellular junction protein ILDR2 in glomerulopathies: Expression patterns and functional insights

iScience
Summary: The tricellular tight junctions are crucial for the regulation of paracellular flux at tricellular junctions, where tricellulin (MARVELD2) and angulins (ILDR1, ILDR2, or LSR) are localized.
Florian Siegerist, Felix Kliewe, Elke Hammer, Paul Schakau, Joanne Ern Chi Soh, Claudia Weber, Maja Lindenmeyer, Simone Reichelt-Wurm, Vedran Drenic, Christos Chatziantoniou, Christos E. Chadjichristos, Yiying Zhang, Stefan Simm, Miriam C. Banas, Matthias Nauck, Uwe Völker, Nicole Endlich   +16 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Physiology Question Paper, 2023

, 2023
Physiology Question ...
Vidyasagar University
core  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Mitochondrial glycerol 3-phosphate dehydrogenase deficiency exacerbates lipotoxic cardiomyopathy

iScience
Summary: Metabolic diseases such as obesity and diabetes induce lipotoxic cardiomyopathy, which is characterized by myocardial lipid accumulation, dysfunction, hypertrophy, fibrosis and mitochondrial dysfunction.
Hua Qu, Xiufei Liu, Jiaran Zhu, Niexia He, Qingshan He, Linlin Zhang, Yuren Wang, Xiaoli Gong, Xin Xiong, Jinbo Liu, Chuan Wang, Gangyi Yang, Qingwu Yang, Gang Luo, Zhiming Zhu, Yi Zheng, Hongting Zheng   +16 more
doaj   +1 more source

O-GlcNAcylation: cellular physiology and therapeutic target for human diseases. [PDF]

MedComm (2020), 2023
Ye L, Ding W, Xiao D, Jia Y, Zhao Z, Ao X, Wang J.   +6 more
europepmc   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Succinate dehydrogenase complex subunit C: Role in cellular physiology and disease. [PDF]

Exp Biol Med (Maywood), 2023
Wang Q, Li M, Zeng N, Zhou Y, Yan J.
europepmc   +1 more source