Results 21 to 30 of about 511,410 (265)

Electronic cigarettes—A review of the physiological health effects

FACETS, 2017
Electronic cigarettes (ECs) are devices that are used recreationally or as smoking cessation tools, and have become increasingly popular in recent years.
Alyssa Zucchet, Grégory Schmaltz
doaj   +1 more source

Pro-α-cell-derived β-cells contribute to β-cell neogenesis induced by antagonistic glucagon receptor antibody in type 2 diabetic mice

iScience, 2022
Summary: The deficiency of pancreatic β-cells is the key pathogenesis of diabetes, while glucagon-secreting α-cells are another player in the development of diabetes.
Xiaona Cui, Jin Feng, Tianjiao Wei, Liangbiao Gu, Dandan Wang, Shan Lang, Kun Yang, Jin Yang, Hai Yan, Rui Wei, Tianpei Hong   +10 more
doaj   +1 more source

The role of Phe150 in human voltage-gated proton channel

iScience, 2022
Summary: The voltage-gated proton channel Hv1 is a member of voltage-gated ion channels containing voltage-sensing domains (VSDs). The VSDs are made of four membrane-spanning segments (S1 through S4), and their function is to detect changes in membrane ...
Xin Wu, Lu Zhang, Liang Hong
doaj   +1 more source

Photodynamic Physiology-Photonanomanipulations in Cellular Physiology with Protein Photosensitizers. [PDF]

Front Physiol, 2017
Singlet oxygen generated in a type II photodynamic action, due to its limited lifetime (1 μs) and reactive distance (
Jiang HN, Li Y, Cui ZJ.
europepmc   +4 more sources

An imbalanced GLP-1R/GIPR co-agonist peptide with a site-specific N-terminal PEGylation to maximize metabolic benefits

iScience
Summary: Glycemic and body weight control gained from GLP-1R agonists remains an unmet need for diabetes and obesity treatment, leading to the development of GLP-1R/GIPR co-agonists.
Xuan Xia, Qianmeng Lin, Zhan Zhou, Yongheng Chen   +3 more
doaj   +1 more source

Piezo1 induces endothelial responses to shear stress via soluble adenylyl Cyclase-IP3R2 circuit

iScience, 2023
Summary: Endothelial cells (ECs) continuously sense and adapt to changes in shear stress generated by blood flow. Here, we show that the activation of the mechanosensitive channel Piezo1 by defined shear forces induces Ca2+ entry into the endoplasmic ...
Dianicha Santana Nunez, Asrar B. Malik, Quinn Lee, Sang Joon Ahn, Arnold Coctecon-Murillo, Dana Lazarko, Irena Levitan, Dolly Mehta, Yulia A. Komarova   +8 more
doaj   +1 more source

Adult-Onset Myopathy with Constitutive Activation of Akt following the Loss of hnRNP-U

iScience, 2020
Summary: Skeletal muscle has the remarkable ability to modulate its mass in response to changes in nutritional input, functional utilization, systemic disease, and age.
Debalina Bagchi, Benjamin D. Mason, Kodilichi Baldino, Bin Li, Eun-Joo Lee, Yuteng Zhang, Linh Khanh Chu, Sherif El Raheb, Indranil Sinha, Ronald L. Neppl   +9 more
doaj   +1 more source

Architects of Pituitary Tumour Growth

Frontiers in Endocrinology, 2022
The pituitary is a master gland responsible for the modulation of critical endocrine functions. Pituitary neuroendocrine tumours (PitNETs) display a considerable prevalence of 1/1106, frequently observed as benign solid tumours. PitNETs still represent a
Maria Eugenia Sabatino, Maria Eugenia Sabatino, Ezequiel Grondona, Ezequiel Grondona, Ana Lucía De Paul, Ana Lucía De Paul   +5 more
doaj   +1 more source

Hepatic Levels of DHA-Containing Phospholipids Instruct SREBP1-Mediated Synthesis and Systemic Delivery of Polyunsaturated Fatty Acids

iScience, 2020
Summary: Polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid (DHA) and arachidonic acid (ARA), play fundamental roles in mammalian physiology.
Daisuke Hishikawa, Keisuke Yanagida, Katsuyuki Nagata, Ayumi Kanatani, Yoshiko Iizuka, Fumie Hamano, Megumi Yasuda, Tadashi Okamura, Hideo Shindou, Takao Shimizu   +9 more
doaj   +1 more source

Enhanced access to the human phosphoproteome with genetically encoded phosphothreonine

Nature Communications, 2022
Protein phosphorylation is a ubiquitous post-translational modification used to regulate cellular processes and proteome architecture by modulating protein-protein interactions.
Jack M. Moen, Kyle Mohler, Svetlana Rogulina, Xiaojian Shi, Hongying Shen, Jesse Rinehart   +5 more
doaj   +1 more source