Results 21 to 30 of about 2,084,390 (260)

Systematic diet composition swap in a mouse genome-scale metabolic model reveals determinants of obesogenic diet metabolism in liver cancer

iScience, 2023
Summary: Dietary nutrient availability and gene expression, together, influence tissue metabolic activity. Here, we explore whether altering dietary nutrient composition in the context of mouse liver cancer suffices to overcome chronic gene expression ...
Frederick Clasen, Patrícia M. Nunes, Gholamreza Bidkhori, Nourdine Bah, Stefan Boeing, Saeed Shoaie, Dimitrios Anastasiou   +6 more
doaj   +1 more source

Skeletal muscle and kidney crosstalk in chronic kidney disease [PDF]

, 2022
The functioning of complex organisms requires a constant and delicate balance of processes both between and within cells, tissues, and organ systems. There is growing appreciation for the role of signalling crosstalk connecting different organ systems of
Jenkin, Kayte A. (R19563), Perry, Ben D. (R19224)   +1 more
core   +1 more source

Linoleic Acid Increases Prostaglandin E2 Release and Reduces Mitochondrial Respiration and Cell Viability in Human Trophoblast-Like Cells [PDF]

, 2019
BACKGROUND/AIMS: The omega 6 fatty acid (FA) linoleic acid (LA) is required for embryonic development; however, omega 6 FAs can alter cellular metabolism via inflammation or modulation of mitochondrial function.
Cuffe, J, Hryciw, Deanne H, Shrestha, Nirajan, McAinch, AJ, Shrestha, N, Hryciw, D, Perkins, Anthony V, Holland, Olivia J, Holland, OJ, Holland, Olivia, Cuffe, JSM, Perkins, Anthony, McAinch, Andrew, McAinch, A, Cuffe, James SM, Perkins, AV, Hryciw, DH   +16 more
core   +1 more source

The role of Phe150 in human voltage-gated proton channel

iScience, 2022
Summary: The voltage-gated proton channel Hv1 is a member of voltage-gated ion channels containing voltage-sensing domains (VSDs). The VSDs are made of four membrane-spanning segments (S1 through S4), and their function is to detect changes in membrane ...
Xin Wu, Lu Zhang, Liang Hong
doaj   +1 more source

Piezo1 induces endothelial responses to shear stress via soluble adenylyl Cyclase-IP3R2 circuit

iScience, 2023
Summary: Endothelial cells (ECs) continuously sense and adapt to changes in shear stress generated by blood flow. Here, we show that the activation of the mechanosensitive channel Piezo1 by defined shear forces induces Ca2+ entry into the endoplasmic ...
Dianicha Santana Nunez, Asrar B. Malik, Quinn Lee, Sang Joon Ahn, Arnold Coctecon-Murillo, Dana Lazarko, Irena Levitan, Dolly Mehta, Yulia A. Komarova   +8 more
doaj   +1 more source

Circulating and tissue resident endothelial progenitor cells

, 2014
Progenitor cells for the endothelial lineage have been widely investigated for more than a decade, but continue to be controversial since no unique identifying marker has yet been identified.
Yoder, Mervin C., Basile, David P.
core   +1 more source

Nmp4/CIZ inhibits mechanically-induced β-catenin signaling activity in osteoblasts

, 2010
Cellular mechanotransduction, the process of converting mechanical signals into biochemical responses within cells, is a critical aspect of bone health.
Bidwell, Joseph P., Wang, Haifang, Pavalko, Fredrick M., Young, Suzanne R., Gerard-O’Riley, Rita, Yang, Zhouqi   +5 more
core   +1 more source

An imbalanced GLP-1R/GIPR co-agonist peptide with a site-specific N-terminal PEGylation to maximize metabolic benefits

iScience
Summary: Glycemic and body weight control gained from GLP-1R agonists remains an unmet need for diabetes and obesity treatment, leading to the development of GLP-1R/GIPR co-agonists.
Xuan Xia, Qianmeng Lin, Zhan Zhou, Yongheng Chen   +3 more
doaj   +1 more source

Architects of Pituitary Tumour Growth

Frontiers in Endocrinology, 2022
The pituitary is a master gland responsible for the modulation of critical endocrine functions. Pituitary neuroendocrine tumours (PitNETs) display a considerable prevalence of 1/1106, frequently observed as benign solid tumours. PitNETs still represent a
Maria Eugenia Sabatino, Maria Eugenia Sabatino, Ezequiel Grondona, Ezequiel Grondona, Ana Lucía De Paul, Ana Lucía De Paul   +5 more
doaj   +1 more source

Hepatic Levels of DHA-Containing Phospholipids Instruct SREBP1-Mediated Synthesis and Systemic Delivery of Polyunsaturated Fatty Acids

iScience, 2020
Summary: Polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid (DHA) and arachidonic acid (ARA), play fundamental roles in mammalian physiology.
Daisuke Hishikawa, Keisuke Yanagida, Katsuyuki Nagata, Ayumi Kanatani, Yoshiko Iizuka, Fumie Hamano, Megumi Yasuda, Tadashi Okamura, Hideo Shindou, Takao Shimizu   +9 more
doaj   +1 more source