Results 21 to 30 of about 2,176,407 (303)

Physiological Functions of the Cellular Prion Protein [PDF]

Frontiers in Molecular Biosciences, 2017
The prion protein, PrPC, is a small, cell-surface glycoprotein notable primarily for its critical role in pathogenesis of the neurodegenerative disorders known as prion diseases. A hallmark of prion diseases is the conversion of PrPC into an abnormally folded isoform, which provides a template for further pathogenic conversion of PrPC, allowing disease
Andrew R. Castle, Andrew Gill
openaire   +4 more sources

Clinical Exercise Physiology Accreditation: An Audit of Existing Standards

, 2023
Background: Health professions such as clinical exercise physiology are founded on a set of standards that outline base level knowledge, skills, and competencies to define the roles and scope of practice of the profession.
Nathan E. Reeves, Carly Ryan, Ryan, Carly, Davison, Kade, Kade Davison, Reeves, Nathan E   +5 more
core   +1 more source

Whole-cell energy modeling reveals quantitative changes of predicted energy flows in RAS mutant cancer cell lines

iScience, 2023
Summary: Cellular utilization of available energy flows to drive a multitude of forms of cellular “work” is a major biological constraint. Cells steer metabolism to address changing phenotypic states but little is known as to how bioenergetics couples to
Thomas Sevrin, Lisa Strasser, Camille Ternet, Philipp Junk, Miriam Caffarini, Stella Prins, Cian D’Arcy, Simona Catozzi, Giorgio Oliviero, Kieran Wynne, Christina Kiel, Philip J. Luthert   +11 more
doaj   +1 more source

Pro-α-cell-derived β-cells contribute to β-cell neogenesis induced by antagonistic glucagon receptor antibody in type 2 diabetic mice

iScience, 2022
Summary: The deficiency of pancreatic β-cells is the key pathogenesis of diabetes, while glucagon-secreting α-cells are another player in the development of diabetes.
Xiaona Cui, Jin Feng, Tianjiao Wei, Liangbiao Gu, Dandan Wang, Shan Lang, Kun Yang, Jin Yang, Hai Yan, Rui Wei, Tianpei Hong   +10 more
doaj   +1 more source

Plant Stress Physiology [PDF]

, 2022
This book includes ten chapters addressing various aspects of plant stress physiology, including plant responses and tolerance to abiotic and biotic stress.

core   +1 more source

Systematic diet composition swap in a mouse genome-scale metabolic model reveals determinants of obesogenic diet metabolism in liver cancer

iScience, 2023
Summary: Dietary nutrient availability and gene expression, together, influence tissue metabolic activity. Here, we explore whether altering dietary nutrient composition in the context of mouse liver cancer suffices to overcome chronic gene expression ...
Frederick Clasen, Patrícia M. Nunes, Gholamreza Bidkhori, Nourdine Bah, Stefan Boeing, Saeed Shoaie, Dimitrios Anastasiou   +6 more
doaj   +1 more source

The role of Phe150 in human voltage-gated proton channel

iScience, 2022
Summary: The voltage-gated proton channel Hv1 is a member of voltage-gated ion channels containing voltage-sensing domains (VSDs). The VSDs are made of four membrane-spanning segments (S1 through S4), and their function is to detect changes in membrane ...
Xin Wu, Lu Zhang, Liang Hong
doaj   +1 more source

Piezo1 induces endothelial responses to shear stress via soluble adenylyl Cyclase-IP3R2 circuit

iScience, 2023
Summary: Endothelial cells (ECs) continuously sense and adapt to changes in shear stress generated by blood flow. Here, we show that the activation of the mechanosensitive channel Piezo1 by defined shear forces induces Ca2+ entry into the endoplasmic ...
Dianicha Santana Nunez, Asrar B. Malik, Quinn Lee, Sang Joon Ahn, Arnold Coctecon-Murillo, Dana Lazarko, Irena Levitan, Dolly Mehta, Yulia A. Komarova   +8 more
doaj   +1 more source

An imbalanced GLP-1R/GIPR co-agonist peptide with a site-specific N-terminal PEGylation to maximize metabolic benefits

iScience
Summary: Glycemic and body weight control gained from GLP-1R agonists remains an unmet need for diabetes and obesity treatment, leading to the development of GLP-1R/GIPR co-agonists.
Xuan Xia, Qianmeng Lin, Zhan Zhou, Yongheng Chen   +3 more
doaj   +1 more source

Photodynamic Physiology-Photonanomanipulations in Cellular Physiology with Protein Photosensitizers. [PDF]

Front Physiol, 2017
Singlet oxygen generated in a type II photodynamic action, due to its limited lifetime (1 μs) and reactive distance (
Jiang HN, Li Y, Cui ZJ.
europepmc   +4 more sources