Results 101 to 110 of about 638,332 (291)

Evaluation of human antibodies from vaccinated volunteers for protection against Yersinia pestis infection

Microbiology Spectrum
Yersinia pestis has a broad host range and has caused lethal bubonic and pneumonic plague in humans. With the emergence of multiple resistant strains and the potential for biothreat use, there is an urgent need for new therapeutic strategies that can ...
Li Zhang, Binyang Zheng, Jing Lu, Haisheng Wu, Hailian Wu, Qi Zhang, Lei Jiao, Hongxing Pan, Jianfang Zhou   +8 more
doaj   +1 more source

Association of hoarding case identification and animal protection programs to socioeconomic indicators in a major metropolitan area of Brazil. [PDF]

Front Vet Sci, 2022
de Moura RR, de Castro WAC, Farinhas JH, da Cunha GR, Pegoraro MMO, Kmetiuk LB, Dos Santos AP, Biondo AW.   +7 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

CONFINED ANIMAL PRODUCTION AND MANURE NUTRIENTS

Census of agriculture data were used to estimate manure nutrient production and the capacity of cropland and pastureland to assimilate nutrients. Most farms (78 percent for nitrogen and 69 percent for phosphorus) have adequate land on which it is ...
Ribaudo, Marc, Lander, Charles, Letson, David, Caswell, Margriet, Gollehon, Noel R., Kellogg, Robert L.   +5 more
core   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Chronicle of the First China Animal Law Forum - Beijing, July 2019 [PDF]

, 2019
On July 11 and 12, 2019 the First China Animal Law Forum was held in Beijing, which was co-hosted by the Capital Animal Welfare Association and the Vshine Animal Protection Association.
Li, Bo
core   +1 more source

Animal Protection, Law Enforcement, and Occupational Health: Qualitative Action Research Highlights the Urgency of Relational Coordination in a Medico-Legal Borderland. [PDF]

Animals (Basel), 2022
Rault D, Adams CL, Springett J, Rock MJ.
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Progress report - Plant Protection and Quarantine Programs.

Report covers fiscal year 1979.Mode of access: Internet.Supersedes: United States. Agricultural Research Service. Plant Protection Division. Annual report - U.S.
United States. Animal and Plant Health Inspection Service. Plant Protection and Quarantine Programs.
core  

Reflections on the Ethical Premises Underlying the Proposed UN Convention on Animal Health and Protection

, 2022
This article examines the ethical underpinnings of the proposed UN Convention on Animal Health and Protection (UNCAHP), a framework treaty drafted by the Global Animal Law Association (GAL).
Şarbak, Hilâl Nur
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