Results 81 to 90 of about 631,180 (251)
Using institutional ethnography to analyse animal sheltering and protection I: Animal protection work. [PDF]
Anim Welf, 2023 Koralesky KE, Rankin JM, Fraser D.
europepmc +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Classification of cases of animal abuse in Ecuador using IndetermSoft and C4.5 algorithms [PDF]
Neutrosophic Sets and SystemsThis dissertation aimed to determine the classification of animal abuse within Ecuador by severity, con text, and solution through the application of IndetermSoft and the statistical-neutrosophic C4.5 algorithm to classify the uncertainty associated with
Viviana del Rocío Marfetan Marfetan +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
The Ombudsman for Animal Protection
Wrocławsko-Lwowskie Zeszyty PrawniczeThe actual defenders of animal rights in Poland are mainly foundations and associations; the organisation of animal protection is largely grassroots, social and non-governmental. This fact arouses a lot of controversy, mainly because concrete actions are
Hanna Spasowska
doaj +1 more source
Environment and legal protection of animals in the Republic of Serbia [PDF]
Ekonomika Poljoprivrede (1979), 2018 The aim of this study was to investigate the application of scientific methods of animal protection in the legal legislation of the Republic of Serbia, through assaults on the environment.
Petrović Zdravko +2 more
doaj
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Association of hoarding case identification and animal protection programs to socioeconomic indicators in a major metropolitan area of Brazil. [PDF]
Front Vet Sci, 2022 de Moura RR +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source