Results 71 to 80 of about 1,622,799 (297)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Neuro-Protection and Neuro-Therapy Effects of Acalypha Indica Linn. Water Extract Ex Vivo on Musculus Gastrocnemius Frog [PDF]
, 2008 The studies of neuro-protection and neuro-therapy effects of Acalypha indica Linn. water extract ex vivo on Musculus gastrocnemius frog have already done at three Departments in Faculty of Medicine, University of Indonesia.
Ibrahim, N. (Nurhadi) +3 more
core +1 more source
Animal Abuse Investigations: Challenges and Recommendations to Improve Animal and Human Welfare
AnimalsAnimal cruelty is widespread, yet it is often overlooked by professionals as a form of trauma and not perceived as a serious crime. This study explores current challenges to the effective management of animal abuse and neglect cases in the state of ...
Rebecca Niemiec, Lori R. Kogan
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Technical economical effects of the measures on the pigs welfare and protection [PDF]
, 2012 The term of animal welfare was chosen to describe the animal life quality. It is derived from the English language. This notion includes health, productive comfort and also involves the animal protection.
Chetroiu, Rodica
core
Compensation of damages for killing or injury of a pet [PDF]
Glasnik Advokatske komore Vojvodine, 2015 The goal of this paper is to consider the legal options of an owner to obtain a recovery from a person who caused the death of the pet, which exceeds the market value of the pet in the case the pet is killed.
Milenković Radmila
doaj
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source