Results 131 to 140 of about 1,874,698 (266)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Plant and Animal Protein Intake and Transitions From Multimorbidity to Frailty and Mortality in Older Adults. [PDF]

J Cachexia Sarcopenia Muscle
Vázquez-Fernández A, Caballero FF, Yévenes-Briones H, Struijk EA, Baylin A, Fung TT, Lopez-Garcia E.   +6 more
europepmc   +1 more source

Plant to animal protein ratio in the diet: nutrient adequacy, long-term health and environmental pressure. [PDF]

Front Nutr, 2023
Fouillet H, Dussiot A, Perraud E, Wang J, Huneau JF, Kesse-Guyot E, Mariotti F.   +6 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dietary plant-to-animal protein ratio and risk of premature coronary artery disease (PCAD): Iran Premature Coronary Artery Disease (IPAD) study. [PDF]

BMC Cardiovasc Disord
Bateni M, Mohammadifard N, Haghighatdoost F, Azar MM, Zarepur E, Belyani S, Salari A, Assareh A, Hosseini S, Nouri F, Sarrafzadegan N.   +10 more
europepmc   +1 more source

Updates on Plant-Based Protein Products as an Alternative to Animal Protein: Technology, Properties, and Their Health Benefits. [PDF]

Molecules, 2023
Xiao X, Zou PR, Hu F, Zhu W, Wei ZJ.
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Effect of Plant Versus Animal Protein on Muscle Mass, Strength, Physical Performance, and Sarcopenia: A Systematic Review and Meta-analysis of Randomized Controlled Trials. [PDF]

Nutr Rev
Reid-McCann RJ, Brennan SF, Ward NA, Logan D, McKinley MC, McEvoy CT.   +5 more
europepmc   +1 more source

Food Sources of Animal Protein in Relation to Overall and Cause-Specific Mortality-Causal Associations or Confounding? An Analysis of the EPIC-Heidelberg Cohort. [PDF]

Nutrients, 2023
Bajracharya R, Kaaks R, Katzke V.
europepmc   +1 more source