Results 171 to 180 of about 321,984 (308)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Influence of a garlic-based additive on the performance parameters and intestinal morphology of replacement gilts in Ukraine under commercial conditions. [PDF]

Vet World
Lykhach V, Bevz N, Lykhach A, Balanchuk I, Faustov R, Shaposhnik V.   +5 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Does a whole millet grain-based diet replace whole corn grain in non-forage diets for goat kids? [PDF]

Trop Anim Health Prod
Santos FLAD, Araújo DLDC, Gonçalves LMP, Soares MCS, Lopes FA, Miranda DFH, Alves AA, Parente HN, de Araújo MJ, Santos FNS, Pinheiro RSB, Parente MOM.   +11 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Partial fishmeal replacement with poultry by-product meal and yeast enhances growth and health in Clarias gariepinus, while unbalanced PBM diets induce metabolic stress. [PDF]

PLoS One
Hamwi NI, Altajer HA.
europepmc   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

Dietary replacement of whole soybean grain with micronized defatted soybean meal in dairy cow diets: effects on intake, digestibility, ruminal parameters, and milk yield and composition. [PDF]

Trop Anim Health Prod
Maciel TTBAFRAALP, Okada ESM, De Oliveira ER, Gandra JR, Banys VL, Da Silva Fernandes T, de Araújo Gabriel AM, Cardoso CAL, Júnior VRR, de Jesus Silva RKO, Monção FP.   +10 more
europepmc   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Effects of BSFL on growing-finishing pigs in growth performance, nutrient digestibility, blood profiles, and gas emission. [PDF]

J Anim Sci Technol
Chang S, Park Y, Lee J, Song D, Jeon K, Kim H, Yang J, Cho J.   +7 more
europepmc   +1 more source