Results 1 to 10 of about 103,660 (112)

Ion Channel Expression and Electrophysiology of Singular Human (Primary and Induced Pluripotent Stem Cell-Derived) Cardiomyocytes

Cells, 2021
Subtype-specific human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are promising tools, e.g., to assess the potential of drugs to cause chronotropic effects (nodal hiPSC-CMs), atrial fibrillation (atrial hiPSC-CMs), or ventricular ...
Christina Schmid, Najah Abi-Gerges, Michael Georg Leitner, Dietmar Zellner, Georg Rast   +4 more
doaj   +3 more sources

SNTA1-deficient human cardiomyocytes demonstrate hypertrophic phenotype and calcium handling disorder [PDF]

Stem Cell Research & Therapy, 2022
Background α-1-syntrophin (SNTA1), a protein encoded by SNTA1, is highly expressed in human cardiomyocytes. Mutations in SNTA1 are associated with arrhythmia and cardiomyopathy. Previous research on SNTA1 has been based on non-human cardiomyocytes.
Tao Dong, Yan Zhao, Hai-Feng Jin, Lei Shen, Yan Lin, Long-Long Si, Li Chen, Ji-Cheng Liu   +7 more
doaj   +2 more sources

Hypoxia and re-oxygenation effects on human cardiomyocytes cultured on polycaprolactone and polyurethane nanofibrous mats [PDF]

Journal of Biological Engineering
Heart diseases are caused mainly by chronic oxygen insufficiency (hypoxia), leading to damage and apoptosis of cardiomyocytes. Research into the regeneration of a damaged human heart is limited due to the lack of cellular models that mimic damaged ...
Zuzanna Iwoń, Ewelina Krogulec, Aleksandra Kierlańczyk, Michał Wojasiński, Elżbieta Jastrzębska   +4 more
doaj   +2 more sources

Modeling Human Cardiac Hypertrophy in Stem Cell-Derived Cardiomyocytes

Stem Cell Reports, 2018
Summary: Cardiac hypertrophy accompanies many forms of cardiovascular diseases. The mechanisms behind the development and regulation of cardiac hypertrophy in the human setting are poorly understood, which can be partially attributed to the lack of a ...
Ekaterina Ovchinnikova, Martijn Hoes, Kirill Ustyantsev, Nils Bomer, Tristan V. de Jong, Henny van der Mei, Eugene Berezikov, Peter van der Meer   +7 more
doaj   +3 more sources

Human induced pluripotent stem cell-derived cardiomyocytes as an electrophysiological model: Opportunities and challenges—The Hamburg perspective

Frontiers in Physiology, 2023
Models based on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are proposed in almost any field of physiology and pharmacology. The development of human induced pluripotent stem cell-derived cardiomyocytes is expected to become a ...
Djemail Ismaili, Djemail Ismaili, Djemail Ismaili, Carl Schulz, Carl Schulz, András Horváth, Jussi T. Koivumäki, Delphine Mika, Arne Hansen, Arne Hansen, Thomas Eschenhagen, Thomas Eschenhagen, Torsten Christ, Torsten Christ   +13 more
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Potential Role of Lisinopril in Reducing Atherosclerotic Risk: Evidence of an Antioxidant Effect in Human Cardiomyocytes Cell Line

Frontiers in Pharmacology, 2022
The cellular mechanisms involved in myocardial ischemia/reperfusion injury (I/R) pathogenesis are complex but attributable to reactive oxygen species (ROS) production.
Lucia Scisciola, Rosaria Anna Fontanella, Surina, Giovanna Garofalo, Maria Rosaria Rizzo, Giuseppe Paolisso, Giuseppe Paolisso, Michelangela Barbieri   +7 more
doaj   +1 more source

MiRNA-615-3p Alleviates Oxidative Stress Injury of Human Cardiomyocytes Via PI3K/Akt Signaling by Targeting MEF2A

Anatolian Journal of Cardiology, 2022
Background: Myocardial infarction, a coronary heart disease, is a serious hazard to human health. Cardiomyocyte oxidative stress and apoptosis have been considered as the main causes of myocardial infarction. Here, we aimed to investigate the role of miR-
Dongying Zhang, Gang Zhang, Kun Yu, Xiwen Zhang, Aixia Jiang   +4 more
doaj   +1 more source

Identification of miRNAs as Biomarkers of Cardiac Protection in Non-Genetically Modified Primary Human Cardiomyocytes Exposed to Halogenated Hypnotics in an In Vitro Model of Transfection and Ischemia/Reperfusion: A New Model in Translational Anesthesia

Life, 2022
Background: Many clinical studies have identified some circulating micro-RNAs (miRNAs) as potential biomarkers with regard to the cardioprotective effects of halogenated agents administered perioperatively during myocardial conditioning procedures ...
Maria Dolores Carmona-Luque, Laura Gonzalez-Alvarez, José Luis Guerrero Orriach   +2 more
doaj   +1 more source

Comparative Effect of MSC Secretome to MSC Co-culture on Cardiomyocyte Gene Expression Under Hypoxic Conditions in vitro

Frontiers in Bioengineering and Biotechnology, 2020
IntroductionDespite major leaps in regenerative medicine, the regeneration of cardiomyocytes after ischemic conditions remains to elucidate. It is crucial to understand hypoxia induced cellular mechanisms to provide advanced treatment options, including ...
Nina Kastner, Julia Mester-Tonczar, Johannes Winkler, Denise Traxler, Andreas Spannbauer, Beate M. Rüger, Georg Goliasch, Noemi Pavo, Mariann Gyöngyösi, Katrin Zlabinger   +9 more
doaj   +1 more source

Empagliflozin and Dapagliflozin Increase Na⁺ and Inward Rectifier K⁺ Current Densities in Human Cardiomyocytes Derived from Induced Pluripotent Stem Cells (hiPSC-CMs)

Cells, 2022
Dapagliflozin (dapa) and empagliflozin (empa) are sodium-glucose cotransporter-2 inhibitors (SGLT2is) that reduce morbidity and mortality in heart failure (HF) patients.
María Dago, Teresa Crespo-García, Anabel Cámara-Checa, Josu Rapún, Marcos Rubio-Alarcón, María Marín, Juan Tamargo, Ricardo Caballero, Eva Delpón   +8 more
doaj   +1 more source