Results 11 to 20 of about 9,526,153 (337)

Chemically Defined and Small Molecule-Based Generation of Human Cardiomyocytes [PDF]

Nature Methods, 2014
Existing methods for human induced pluripotent stem cell (hiPSC) cardiac differentiation are efficient but require complex, undefined medium constituents that hinder further elucidation of the molecular mechanisms of cardiomyogenesis.
P. Burridge, Elena Matsa, Praveen K. Shukla, Z. Lin, Jared M. Churko, Antje D. Ebert, F. Lan, Sebastian Diecke, B. Huber, N. Mordwinkin, J. Plews, O. Abilez, B. Cui, Joseph D. Gold, Joseph C. Wu   +14 more
semanticscholar   +3 more sources

The toxicity of lithium to human cardiomyocytes [PDF]

Environmental Sciences Europe, 2020
Background Lithium is widely used in the electronic consumer market and electric vehicles and has a great contribution to the world economy, resulting in large quantities of lithium waste in the environment.
Junwei Shen, Xin Li, Xiujuan Shi, Wei Wang, Hua Zhou, Jiawen Wu, Xin Wang, Jue Li   +7 more
semanticscholar   +4 more sources

Effect of Hypoxia on Irisin Secretion by Human Cardiomyocytes. [PDF]

In Vivo
Cardiovascular disease (CVD) is the leading cause of death worldwide, accounting for 31% of all deaths. Biomarkers such as troponins and natriuretic peptides are crucial in diagnosing CVD. Recently, irisin (Ir), a myokine derived from the cleavage of fibronectin type III domain-containing protein 5 (FNDC5), has been identified as a potential new ...
Grzeszczuk M, Ciesielska U, Rusak A, Kulus MJ, Haczkiewicz-Leśniak K, Jabłońska K, Kmiecik A, Podhorska-Okołów M, Dzięgiel P, Nowińska K.   +9 more
europepmc   +3 more sources

Human induced pluripotent stem cell-derived cardiomyocytes as an electrophysiological model: Opportunities and challenges—The Hamburg perspective

Frontiers in Physiology, 2023
Models based on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are proposed in almost any field of physiology and pharmacology. The development of human induced pluripotent stem cell-derived cardiomyocytes is expected to become a ...
Djemail Ismaili, Djemail Ismaili, Djemail Ismaili, Carl Schulz, Carl Schulz, András Horváth, Jussi T. Koivumäki, Delphine Mika, Arne Hansen, Arne Hansen, Thomas Eschenhagen, Thomas Eschenhagen, Torsten Christ, Torsten Christ   +13 more
doaj   +1 more source

Potential Role of Lisinopril in Reducing Atherosclerotic Risk: Evidence of an Antioxidant Effect in Human Cardiomyocytes Cell Line

Frontiers in Pharmacology, 2022
The cellular mechanisms involved in myocardial ischemia/reperfusion injury (I/R) pathogenesis are complex but attributable to reactive oxygen species (ROS) production.
Lucia Scisciola, Rosaria Anna Fontanella, Surina, Giovanna Garofalo, Maria Rosaria Rizzo, Giuseppe Paolisso, Giuseppe Paolisso, Michelangela Barbieri   +7 more
doaj   +1 more source

Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread oxidative genotoxicity

Nature Aging, 2022
The accumulation of somatic DNA mutations over time is a hallmark of aging in many dividing and nondividing cells but has not been studied in postmitotic human cardiomyocytes. Using single-cell whole-genome sequencing, we identified and characterized the
S. Choudhury, A. Huang, Junho Kim, Zinan Zhou, Katherine S. Morillo, Eduardo A. Maury, Jessica W Tsai, Michael B. Miller, Michael A. Lodato, Sarah Araten, N. Hilal, E. Lee, M. Chen, Christopher A. Walsh   +13 more
semanticscholar   +1 more source

MiRNA-615-3p Alleviates Oxidative Stress Injury of Human Cardiomyocytes Via PI3K/Akt Signaling by Targeting MEF2A

Anatolian Journal of Cardiology, 2022
Background: Myocardial infarction, a coronary heart disease, is a serious hazard to human health. Cardiomyocyte oxidative stress and apoptosis have been considered as the main causes of myocardial infarction. Here, we aimed to investigate the role of miR-
Dongying Zhang, Gang Zhang, Kun Yu, Xiwen Zhang, Aixia Jiang   +4 more
doaj   +1 more source

Cardiomyocyte Renewal in Humans [PDF]

Circulation Research, 2012
Pas de ...
Bergmann, Olaf, Zdunek, Sofia, Frisén, Jonas, Bernard, Samuel, Druid, Henrik, Jovinge, Stefan   +5 more
openaire   +4 more sources

Generation of high-performance human cardiomyocytes and engineered heart tissues from extended pluripotent stem cells

Cell Discovery, 2022
The availability of functional human cardiomyocytes is essential for cardiac disease modeling, drug screening, and cell therapy, whereas donor human cardiomyocytes are incredibly scarce.
Li Li, Z. Wan, Ruxiang Wang, Yuxin Zhao, Yida Ye, Pengcheng Yang, Yan Qi, Wei Jiang, Lingling Cai, Donghui Zhang   +9 more
semanticscholar   +1 more source

Evidence for Cardiomyocyte Renewal in Humans [PDF]

Science, 2009
It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes
Bergmann, Olaf, Bhardwaj, Ratan D, Bernard, Samuel, Zdunek, Sofia, Barnabé-Heider, Fanie, Walsh, Stuart, Zupicich, Joel, Alkass, Kanar, Buchholz, Bruce A, Druid, Henrik, Jovinge, Stefan, Frisén, Jonas   +11 more
openaire   +3 more sources