Results 11 to 20 of about 103,809 (257)

Human cardiomyocytes for drug discovery

Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2018
Introduction: Cardiac drug discovery are based in old methods that use animals, animal cells or modified cells that do not faithfully represent human cardiac phenotypes.
Diogo Gonçalves Biagi, Jéssica Gonçalves, Estela Cruvinel, Renata Damiani, Flavia Valgode, Fabiana Medeiros, Camila G Moreira, Evelyn Santos, Rodrigo Marcon, Calixto João, Gabriela Venturini, Alexandre Pereira, Éden Ferreira, Renato Mortara, Marcos C Valadares   +14 more
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Requirements for human cardiomyocytes. [PDF]

Cell Prolif, 2022
Abstract‘Requirements for human cardiomyocytes', jointly drafted and agreed upon by experts from the Chinese Society for Stem Cell Research, is the first guideline for human cardiomyocytes in China. This standard specifies the technical requirements, test methods, test regulations, instructions for use, labelling requirements, packing requirements ...
Yu M, Lei W, Cao J, Wang L, Ma A, Zhao ZA, Yang HT, Shen Z, Lan F, Cao F, Liang P, Pei X, Xiang AP, Yu J, Zhang Y, Zhang Y, Li Q, Zhou J, Wei J, Peng Y, Zhu H, Liang L, Cao N, Fu B, Hao J, Zhao T, Hu S.   +26 more
europepmc   +4 more sources

Effect of Hypoxia on Irisin Secretion by Human Cardiomyocytes. [PDF]

In Vivo
Cardiovascular disease (CVD) is the leading cause of death worldwide, accounting for 31% of all deaths. Biomarkers such as troponins and natriuretic peptides are crucial in diagnosing CVD. Recently, irisin (Ir), a myokine derived from the cleavage of fibronectin type III domain-containing protein 5 (FNDC5), has been identified as a potential new ...
Grzeszczuk M, Ciesielska U, Rusak A, Kulus MJ, Haczkiewicz-Leśniak K, Jabłońska K, Kmiecik A, Podhorska-Okołów M, Dzięgiel P, Nowińska K.   +9 more
europepmc   +3 more sources

Cardiomyocyte Renewal in Humans [PDF]

Circulation Research, 2012
Pas de ...
Bergmann, Olaf, Zdunek, Sofia, Frisén, Jonas, Bernard, Samuel, Druid, Henrik, Jovinge, Stefan   +5 more
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Evidence for Cardiomyocyte Renewal in Humans [PDF]

Science, 2009
It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes
Bergmann, Olaf, Bhardwaj, Ratan D, Bernard, Samuel, Zdunek, Sofia, Barnabé-Heider, Fanie, Walsh, Stuart, Zupicich, Joel, Alkass, Kanar, Buchholz, Bruce A, Druid, Henrik, Jovinge, Stefan, Frisén, Jonas   +11 more
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The toxicity of lithium to human cardiomyocytes [PDF]

Environmental Sciences Europe, 2020
Abstract Background: Lithium is widely used in the electronic consumer market and electric vehicles and has a great contribution in the world economy, resulting in large quantities of lithium waste in the environment. Yangtze River basin is one of the most developed areas in China.
Junwei Shen, Xin Li, Xiujuan Shi, Wei Wang, Hua Zhou, Jiawen Wu, Xin Wang, Jue Li   +7 more
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Chemically defined generation of human cardiomyocytes [PDF]

Nature Methods, 2014
Existing methods for human induced pluripotent stem cell (hiPSC) cardiac differentiation are efficient but require complex, undefined medium constituents that hinder further elucidation of the molecular mechanisms of cardiomyogenesis. Using hiPSCs derived under chemically defined conditions on synthetic matrices, we systematically developed an ...
Paul W Burridge, Elena Matsa, Praveen Shukla, Ziliang C Lin, Jared M Churko, Antje D Ebert, Feng Lan, Sebastian Diecke, Bruno Huber, Nicholas M Mordwinkin, Jordan R Plews, Oscar J Abilez, Bianxiao Cui, Joseph D Gold, Joseph C Wu   +14 more
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Preconditioning human cardiomyocytes and endothelial cells [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 1998
The effects of simulated "ischemia" and "reperfusion" were evaluated in cell cultures of human ventricular cardiomyocytes and human saphenous vein endothelial cells.Myocyte and endothelial cell cultures were exposed to a low volume (1.5 ml) of either hypoxic (oxygen tension = 16 mm Hg) or anoxic (oxygen tension = 0 mm Hg) phosphate-buffered saline ...
Shirai, Toshizumi, Rao, Vivek, Weisel, Richard D., Ikonomidis, John S., Li, Ren-Ke, Tumiati, Laura C., Merante, Frank, Mickle, Donald A.   +7 more
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Cardiomyocytes Derived from Human CardiopoieticAmniotic Fluids [PDF]

Scientific Reports, 2018
AbstractHuman amniotic fluid (hAF) cells share characteristics of both embryonic and adult stem cells. They proliferate rapidly and can differentiate into cells of all embryonic germ layers but do not form teratomas. Embryoid-bodies obtained from hAF have cardiac differentiation potential, but terminal differentiation to cardiomyocytes (CMs) has not ...
Di Baldassarre, Angela, D’Amico, Maria A., Izzicupo, Pascal, Gaggi, Giulia, Guarnieri, Simone, Mariggiò, Maria A., Antonucci, Ivana, Corneo, Barbara, Sirabella, Dario, Stuppia, Liborio, Ghinassi, Barbara   +10 more
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Single-cell transcriptomic profiling reveals specific maturation signatures in human cardiomyocytes derived from LMNB2-inactivated induced pluripotent stem cells

Frontiers in Cell and Developmental Biology, 2022
Mammalian cardiomyocyte maturation entails phenotypic and functional optimization during the late fetal and postnatal phases of heart development, both processes driven and coordinated by complex gene regulatory networks.
Jie Wang, William Morgan, William Morgan, William Morgan, Ankur Saini, Ankur Saini, Ankur Saini, Tao Liu, John Lough, John Lough, Lu Han, Lu Han, Lu Han   +12 more
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