Results 11 to 20 of about 7,574,392 (244)
Human cardiomyocytes for drug discovery [PDF]
Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2018 Introduction: Cardiac drug discovery are based in old methods that use animals, animal cells or modified cells that do not faithfully represent human cardiac phenotypes.
Diogo Gonçalves Biagi +14 more
doaj +8 more sources
Cyclin A2 induces cytokinesis in human adult cardiomyocytes and drives reprogramming in mice
npj Regenerative MedicineCyclin A2 (CCNA2), a master cell cycle regulator silenced in postnatal cardiomyocytes, promotes cardiac repair in animal models. However, its effect on cytokinesis in adult human cardiomyocytes was previously unknown.
Esmaa Bouhamida +9 more
doaj +2 more sources
The role of bone marrow derived cells in cardiac repair [PDF]
, 2012 PhDCurrent pharmacological therapies fail to address the final end-point of cardiac ischaemia — the death and dysfunction of cardiomyocytes. Advances in stem cell biology have provided hope, for the first time, of addressing this underlying pathology.
Lovell, Matthew J.
core +4 more sources
Loss-of-function of leptin receptor impairs metabolism in human cardiomyocytes [PDF]
, 2023 Background and aims: Leptin resistance or leptin signalling deficiency are associated with increased risk of diabetic cardiomyopathy and heart failure, which is a leading cause of obesity- and diabetes type 2 (T2DM)-related morbidity and mortality ...
Strano, Anna
core +5 more sources
Reactivation of the mitosis-promoting factor in postmitotic cardiomyocytes [PDF]
, 2003 Cardiomyocytes cease to divide shortly after birth and an irreversible cell cycle arrest is evident accompanied by the downregulation of cyclin-dependent kinase activities.
Datwyler, D. A. +11 more
core +1 more source
Stem Cell Research & Therapy, 2022 Background α-1-syntrophin (SNTA1), a protein encoded by SNTA1, is highly expressed in human cardiomyocytes. Mutations in SNTA1 are associated with arrhythmia and cardiomyopathy. Previous research on SNTA1 has been based on non-human cardiomyocytes.
Tao Dong +7 more
doaj +1 more source
Cells, 2022 Live-cell imaging techniques are essential for acquiring vital physiological and pathophysiological knowledge to understand and treat heart disease. For live-cell imaging of transient alterations of [Ca2+]i in human cardiomyocytes, we engineered human ...
Aviseka Acharya +8 more
doaj +1 more source
A modified method for isolation of human cardiomyocytes to model cardiac diseases
Journal of Translational Medicine, 2018 Background Cardiomyocytes derived from animals and induced pluripotent stem cells (iPSCs) are two main cellular models to study cardiovascular diseases, however, neither provides precise modeling of the response of mature human cardiomyocytes to disease ...
Guang-ran Guo +5 more
doaj +1 more source
Yulink, predicted from evolutionary analysis, is involved in cardiac function
Journal of Biomedical Science, 2021 Background The comparative evolutionary genomics analysis was used to study the functions of novel Ka/Ks-predicted human exons in a zebrafish model. The Yulink (MIOS, Entrez Gene: 54,468), a conserved gene from zebrafish to human with WD40 repeats at N ...
Ming-Wei Kuo +5 more
doaj +1 more source
Stem Cell Reports, 2017 We hypothesized that the neonatal rat heart would bring transplanted human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to maturity as it grows to adult size.
Shin Kadota +3 more
doaj +1 more source