Results 11 to 20 of about 113,516 (292)

Human cardiomyocytes for drug discovery

Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2018
Introduction: Cardiac drug discovery are based in old methods that use animals, animal cells or modified cells that do not faithfully represent human cardiac phenotypes.
Diogo Gonçalves Biagi, Jéssica Gonçalves, Estela Cruvinel, Renata Damiani, Flavia Valgode, Fabiana Medeiros, Camila G Moreira, Evelyn Santos, Rodrigo Marcon, Calixto João, Gabriela Venturini, Alexandre Pereira, Éden Ferreira, Renato Mortara, Marcos C Valadares   +14 more
doaj   +10 more sources

Human induced pluripotent stem cell-derived cardiomyocytes as an electrophysiological model: Opportunities and challenges—The Hamburg perspective [PDF]

Frontiers in Physiology, 2023
Models based on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are proposed in almost any field of physiology and pharmacology. The development of human induced pluripotent stem cell-derived cardiomyocytes is expected to become a ...
Djemail Ismaili, Djemail Ismaili, Djemail Ismaili, Carl Schulz, Carl Schulz, András Horváth, Jussi T. Koivumäki, Delphine Mika, Arne Hansen, Arne Hansen, Thomas Eschenhagen, Thomas Eschenhagen, Torsten Christ, Torsten Christ   +13 more
doaj   +2 more sources

Requirements for human cardiomyocytes. [PDF]

Cell Prolif, 2022
Abstract‘Requirements for human cardiomyocytes', jointly drafted and agreed upon by experts from the Chinese Society for Stem Cell Research, is the first guideline for human cardiomyocytes in China. This standard specifies the technical requirements, test methods, test regulations, instructions for use, labelling requirements, packing requirements ...
Yu M, Lei W, Cao J, Wang L, Ma A, Zhao ZA, Yang HT, Shen Z, Lan F, Cao F, Liang P, Pei X, Xiang AP, Yu J, Zhang Y, Zhang Y, Li Q, Zhou J, Wei J, Peng Y, Zhu H, Liang L, Cao N, Fu B, Hao J, Zhao T, Hu S.   +26 more
europepmc   +4 more sources

Preconditioning human cardiomyocytes and endothelial cells [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 1998
The effects of simulated "ischemia" and "reperfusion" were evaluated in cell cultures of human ventricular cardiomyocytes and human saphenous vein endothelial cells.Myocyte and endothelial cell cultures were exposed to a low volume (1.5 ml) of either hypoxic (oxygen tension = 16 mm Hg) or anoxic (oxygen tension = 0 mm Hg) phosphate-buffered saline ...
Shirai, Toshizumi, Rao, Vivek, Weisel, Richard D., Ikonomidis, John S., Li, Ren-Ke, Tumiati, Laura C., Merante, Frank, Mickle, Donald A.   +7 more
openaire   +3 more sources

Effect of Hypoxia on Irisin Secretion by Human Cardiomyocytes. [PDF]

In Vivo
Cardiovascular disease (CVD) is the leading cause of death worldwide, accounting for 31% of all deaths. Biomarkers such as troponins and natriuretic peptides are crucial in diagnosing CVD. Recently, irisin (Ir), a myokine derived from the cleavage of fibronectin type III domain-containing protein 5 (FNDC5), has been identified as a potential new ...
Grzeszczuk M, Ciesielska U, Rusak A, Kulus MJ, Haczkiewicz-Leśniak K, Jabłońska K, Kmiecik A, Podhorska-Okołów M, Dzięgiel P, Nowińska K.   +9 more
europepmc   +3 more sources

Chemically defined generation of human cardiomyocytes [PDF]

Nature Methods, 2014
Existing methods for human induced pluripotent stem cell (hiPSC) cardiac differentiation are efficient but require complex, undefined medium constituents that hinder further elucidation of the molecular mechanisms of cardiomyogenesis. Using hiPSCs derived under chemically defined conditions on synthetic matrices, we systematically developed an ...
Paul W Burridge, Elena Matsa, Praveen Shukla, Ziliang C Lin, Jared M Churko, Antje D Ebert, Feng Lan, Sebastian Diecke, Bruno Huber, Nicholas M Mordwinkin, Jordan R Plews, Oscar J Abilez, Bianxiao Cui, Joseph D Gold, Joseph C Wu   +14 more
openaire   +3 more sources

SNTA1-deficient human cardiomyocytes demonstrate hypertrophic phenotype and calcium handling disorder [PDF]

Stem Cell Research & Therapy, 2022
Background α-1-syntrophin (SNTA1), a protein encoded by SNTA1, is highly expressed in human cardiomyocytes. Mutations in SNTA1 are associated with arrhythmia and cardiomyopathy. Previous research on SNTA1 has been based on non-human cardiomyocytes.
Tao Dong, Yan Zhao, Hai-Feng Jin, Lei Shen, Yan Lin, Long-Long Si, Li Chen, Ji-Cheng Liu   +7 more
doaj   +2 more sources

Ion Channel Expression and Electrophysiology of Singular Human (Primary and Induced Pluripotent Stem Cell-Derived) Cardiomyocytes

Cells, 2021
Subtype-specific human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are promising tools, e.g., to assess the potential of drugs to cause chronotropic effects (nodal hiPSC-CMs), atrial fibrillation (atrial hiPSC-CMs), or ventricular ...
Christina Schmid, Najah Abi-Gerges, Michael Georg Leitner, Dietmar Zellner, Georg Rast   +4 more
doaj   +3 more sources

Adiponectin is synthesized and secreted by human and murine cardiomyocytes

FEBS Letters, 2005
Adiponectin is thought to play a decisive role in the relationships among obesity, insulin resistance and cardiovascular risk. This study investigated whether cardiomyocytes synthesize and secrete adiponectin, and the effects of this hormone on cardiac cells.
Piñeiro, Roberto, Iglesias, María J., Gallego, Rosalía, Raghay, Kawtar, Eiras, Sonia, Rubio, José, Diéguez, Carlos, Gualillo, Oreste, González-Juanatey, José R., Lago, Francisca   +9 more
openaire   +3 more sources

In Vivo Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Neonatal and Adult Rat Hearts

Stem Cell Reports, 2017
We hypothesized that the neonatal rat heart would bring transplanted human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to maturity as it grows to adult size.
Shin Kadota, Lil Pabon, Hans Reinecke, Charles E. Murry   +3 more
doaj   +2 more sources