Results 41 to 50 of about 113,516 (292)

A modified method for isolation of human cardiomyocytes to model cardiac diseases

Journal of Translational Medicine, 2018
Background Cardiomyocytes derived from animals and induced pluripotent stem cells (iPSCs) are two main cellular models to study cardiovascular diseases, however, neither provides precise modeling of the response of mature human cardiomyocytes to disease ...
Guang-ran Guo, Liang Chen, Man Rao, Kai Chen, Jiang-ping Song, Sheng-shou Hu   +5 more
doaj   +1 more source

Yulink, predicted from evolutionary analysis, is involved in cardiac function

Journal of Biomedical Science, 2021
Background The comparative evolutionary genomics analysis was used to study the functions of novel Ka/Ks-predicted human exons in a zebrafish model. The Yulink (MIOS, Entrez Gene: 54,468), a conserved gene from zebrafish to human with WD40 repeats at N ...
Ming-Wei Kuo, Hsiu-Hui Tsai, Sheng-Hung Wang, Yi-Yin Chen, Alice L. Yu, John Yu   +5 more
doaj   +1 more source

Assessment of Cardiomyocyte Contraction in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes [PDF]

Toxicological Sciences, 2014
Functional changes to cardiomyocytes are a common cause of attrition in preclinical and clinical drug development. Current approaches to assess cardiomyocyte contractility in vitro are limited to low-throughput methods not amenable to early drug discovery.
Amy, Pointon, Alexander R, Harmer, Ian L, Dale, Najah, Abi-Gerges, Joanne, Bowes, Christopher, Pollard, Helen, Garside   +6 more
openaire   +2 more sources

Effects of local activation times on the tension development of human cardiomyocytes in a computational model

Current Directions in Biomedical Engineering, 2018
The human heart is an organ of high complexity and hence, very challenging to simulate. To calculate the force developed by the human heart and therefore the tension of the muscle fibers, accurate models are necessary.
Müller Armin, Kovacheva Ekaterina, Schuler Steffen, Dössel Olaf, Baron Lukas   +4 more
doaj   +2 more sources

Burst-Like Transcription of Mutant and Wildtype MYH7-Alleles as Possible Origin of Cell-to-Cell Contractile Imbalance in Hypertrophic Cardiomyopathy

Frontiers in Physiology, 2018
Hypertrophic Cardiomyopathy (HCM) has been related to many different mutations in more than 20 different, mostly sarcomeric proteins. While development of the HCM-phenotype is thought to be triggered by the different mutations, a common mechanism remains
Judith Montag, Kathrin Kowalski, Mirza Makul, Pia Ernstberger, Ante Radocaj, Julia Beck, Edgar Becker, Snigdha Tripathi, Britta Keyser, Christian Mühlfeld, Kirsten Wissel, Andreas Pich, Jolanda van der Velden, Cristobal G. dos Remedios, Andreas Perrot, Antonio Francino, Francesco Navarro-López, Bernhard Brenner, Theresia Kraft   +18 more
doaj   +1 more source

Electrophysiological Biomarkers for Age-Related Changes in Human Atrial Cardiomyocytes: In Silico Study [PDF]

ITM Web of Conferences, 2020
Age-related changes in human cardiomyocytes are closely related to cardiac diseases, especially atrial fibrillation. Restricted availability of biological preparations from the human atrial myocardium complicates experimental studies on the aging ...
Nesterova Tatyana, Ushenin Konstantin, Shmarko Dmitry, Solovyova Olga   +3 more
doaj   +1 more source

Electroporation Parameters for Human Cardiomyocyte Ablation In Vitro

Journal of Cardiovascular Development and Disease, 2022
Cardiac ablation with irreversible electroporation (IRE) is quickly being established as a modality of choice for atrial fibrillation treatment. While it has not yet been optimised, IRE has the potential to significantly limit collateral damage and improve cell-specific targeting associated with other energy sources.
Jara M. Baena-Montes, Tony O’Halloran, Cormac Clarke, Kevin Donaghey, Eoghan Dunne, Martin O’Halloran, Leo R. Quinlan   +6 more
openaire   +3 more sources

Inhibition of miR-128-3p by Tongxinluo Protects Human Cardiomyocytes from Ischemia/reperfusion Injury via Upregulation of p70s6k1/p-p70s6k1

Frontiers in Pharmacology, 2017
Background and Aims: Tongxinluo (TXL) is a multifunctional traditional Chinese medicine that has been widely used to treat cardiovascular and cerebrovascular diseases.
Gui-hao Chen, Chuan-sheng Xu, Jie Zhang, Qing Li, He-he Cui, Xiang-dong Li, Li-ping Chang, Rui-jie Tang, Jun-yan Xu, Xia-qiu Tian, Pei-sen Huang, Jun Xu, Chen Jin, Yue-jin Yang   +13 more
doaj   +1 more source

Vacuolated cardiomyocytes in human endomyocardial biopsy specimens [PDF]

Journal of Cardiology Cases, 2020
We encountered an unfamiliar finding during electron microscopic examination of an endomyocardial biopsy obtained from a 55-year-old woman suffering from heart failure due to dilated phase hypertrophic cardiomyopathy. Many cardiomyocytes contained large vacuoles that were mainly empty except for small amounts of amorphous substrate.
Genzou, Takemura, Kenji, Onoue, Takanori, Arimoto, Tetsu, Watanabe, Akiko, Tsujimoto, Chihiro, Takada, Hideshi, Okada, Tomoya, Nakano, Yasuhiro, Sakaguchi, Nagisa, Miyazaki, Takatomo, Watanabe, Hiromitsu, Kanamori, Shinji, Ogura, Yoshihiko, Saito, Takako, Fujiwara, Hisayoshi, Fujiwara, Yasuaki, Hotta   +16 more
openaire   +2 more sources

Exercise training corrects control of spontaneous calcium waves in hearts from myocardial infarction heart failure rats [PDF]

, 2011
Impaired cardiac control of intracellular diastolic Ca²⁺ gives rise to arrhythmias. Whereas exercise training corrects abnormal cyclic Ca²⁺ handling in heart failure, the effect on diastolic Ca<sup>2 ...
Kemi, Ole J., Wisloff, Ulrik, Morten A. Hoydal, MacQuaide, Niall, Godfrey L. Smith, Hoydal, Morten A., Smith, Godfrey L., Ellingsen, Oyvind, Oyvind Ellingsen, Smith, Godfrey L, Niall MacQuaide, Ole J. Kemi, Ulrik Wisloff   +12 more
core   +1 more source