Results 41 to 50 of about 9,526,153 (337)

Comparing the signaling and transcriptome profiling landscapes of human iPSC-derived and primary rat neonatal cardiomyocytes

Scientific Reports, 2023
The inaccessibility of human cardiomyocytes significantly hindered years of cardiovascular research efforts. To overcome these limitations, non-human cell sources were used as proxies to study heart function and associated diseases.
Kyla Bourque, Jace Jones-Tabah, Darlaine Pétrin, Ryan D. Martin, Jason C. Tanny, Terence E. Hébert   +5 more
doaj   +1 more source

Electrophysiological Biomarkers for Age-Related Changes in Human Atrial Cardiomyocytes: In Silico Study [PDF]

ITM Web of Conferences, 2020
Age-related changes in human cardiomyocytes are closely related to cardiac diseases, especially atrial fibrillation. Restricted availability of biological preparations from the human atrial myocardium complicates experimental studies on the aging ...
Nesterova Tatyana, Ushenin Konstantin, Shmarko Dmitry, Solovyova Olga   +3 more
doaj   +1 more source

Peptide-enhanced mRNA transfection in cultured mouse cardiac fibroblasts and direct reprogramming towards cardiomyocyte-like cells. [PDF]

, 2015
The treatment of myocardial infarction is a major challenge in medicine due to the inability of heart tissue to regenerate. Direct reprogramming of endogenous cardiac fibroblasts into functional cardiomyocytes via the delivery of transcription factor ...
Kim, Hyun Jin, Lee, Kunwoo, Lingampalli, Nithya, Murthy, Niren, Tang, Richard, Yu, Pengzhi   +5 more
core   +3 more sources

MCL-1 Inhibition by Selective BH3 Mimetics Disrupts Mitochondrial Dynamics Causing Loss of Viability and Functionality of Human Cardiomyocytes

iScience, 2020
Summary MCL-1 is a well-characterized inhibitor of cell death that has also been shown to be a regulator of mitochondrial dynamics in human pluripotent stem cells.
Megan L. Rasmussen, Nilay Taneja, Abigail C. Neininger, Lili Wang, Gabriella L. Robertson, Stellan Riffle, Linzheng Shi, B. Knollmann, D. Burnette, V. Gama   +9 more
semanticscholar   +1 more source

Electroporation Parameters for Human Cardiomyocyte Ablation In Vitro

Journal of Cardiovascular Development and Disease, 2022
Cardiac ablation with irreversible electroporation (IRE) is quickly being established as a modality of choice for atrial fibrillation treatment. While it has not yet been optimised, IRE has the potential to significantly limit collateral damage and improve cell-specific targeting associated with other energy sources.
Jara M. Baena-Montes, Tony O’Halloran, Cormac Clarke, Kevin Donaghey, Eoghan Dunne, Martin O’Halloran, Leo R. Quinlan   +6 more
openaire   +3 more sources

Vacuolated cardiomyocytes in human endomyocardial biopsy specimens [PDF]

Journal of Cardiology Cases, 2020
We encountered an unfamiliar finding during electron microscopic examination of an endomyocardial biopsy obtained from a 55-year-old woman suffering from heart failure due to dilated phase hypertrophic cardiomyopathy. Many cardiomyocytes contained large vacuoles that were mainly empty except for small amounts of amorphous substrate.
Genzou, Takemura, Kenji, Onoue, Takanori, Arimoto, Tetsu, Watanabe, Akiko, Tsujimoto, Chihiro, Takada, Hideshi, Okada, Tomoya, Nakano, Yasuhiro, Sakaguchi, Nagisa, Miyazaki, Takatomo, Watanabe, Hiromitsu, Kanamori, Shinji, Ogura, Yoshihiko, Saito, Takako, Fujiwara, Hisayoshi, Fujiwara, Yasuaki, Hotta   +16 more
openaire   +2 more sources

Effects of local activation times on the tension development of human cardiomyocytes in a computational model

Current Directions in Biomedical Engineering, 2018
The human heart is an organ of high complexity and hence, very challenging to simulate. To calculate the force developed by the human heart and therefore the tension of the muscle fibers, accurate models are necessary.
Müller Armin, Kovacheva Ekaterina, Schuler Steffen, Dössel Olaf, Baron Lukas   +4 more
doaj   +2 more sources

Comparison of Non-human Primate versus Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Treatment of Myocardial Infarction. [PDF]

, 2018
Non-human primates (NHPs) can serve as a human-like model to study cell therapy using induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). However, whether the efficacy of NHP and human iPSC-CMs is mechanistically similar remains unknown.
Aguirre, Aitor, Chen, Haodong, Chour, Tony, Holmström, Alexandra, Itzhaki, Ilanit, Jain, Mohit, Kim, Youngkyun, Lehmann, Kim, Ndoye, Babacar C, Neofytou, Evgenios, Qin, Xulei, Shukla, Praveen, Wu, Joseph C, Xiao, Dan, Yang, Huaxiao, Zhang, Joe Z, Zhao, Mingtao, Zhao, Xin, Zhuge, Yan, Zimmermann, Wolfram-Hubertus   +19 more
core   +6 more sources

Burst-Like Transcription of Mutant and Wildtype MYH7-Alleles as Possible Origin of Cell-to-Cell Contractile Imbalance in Hypertrophic Cardiomyopathy

Frontiers in Physiology, 2018
Hypertrophic Cardiomyopathy (HCM) has been related to many different mutations in more than 20 different, mostly sarcomeric proteins. While development of the HCM-phenotype is thought to be triggered by the different mutations, a common mechanism remains
Judith Montag, Kathrin Kowalski, Mirza Makul, Pia Ernstberger, Ante Radocaj, Julia Beck, Edgar Becker, Snigdha Tripathi, Britta Keyser, Christian Mühlfeld, Kirsten Wissel, Andreas Pich, Jolanda van der Velden, Cristobal G. dos Remedios, Andreas Perrot, Antonio Francino, Francesco Navarro-López, Bernhard Brenner, Theresia Kraft   +18 more
doaj   +1 more source

Antisense-mediated exon skipping: a therapeutic strategy for titin-based dilated cardiomyopathy [PDF]

, 2015
Frameshift mutations in the TTN gene encoding titin are a major cause for inherited forms of dilated cardiomyopathy (DCM), a heart disease characterized by ventricular dilatation, systolic dysfunction, and progressive heart failure. To date, there are no
Alessandra, Moretti, Alexander, Goedel, Annemieke Aartsma, Rus, Brenda, Gerull, Daniel, Sinnecker, Elvira, Parrotta, John J., Atherton, Julie, Mcgaughran, Karl Ludwig, Laugwitz, Katja, Metzger, Ludwig, Thierfelder, Luna Simona, Pane, Martin, Schaller, Matthias, Mann, Meinrad Paul, Gawaz, Michael, Gramlich, Murgia, Marta, Qifeng, Zhou, Richard P., Harvey, Siegfried, Labeit, Sonja, Sch\uf6tterl, Thomas, Brade, Zhifen, Chen   +22 more
core   +1 more source