Results 41 to 50 of about 7,574,392 (244)

Engineering human ventricular heart muscles based on a highly efficient system for purification of human pluripotent stem cell-derived ventricular cardiomyocytes

Stem Cell Research & Therapy, 2017
Background Most infarctions occur in the left anterior descending coronary artery and cause myocardium damage of the left ventricle. Although current pluripotent stem cells (PSCs) and directed cardiac differentiation techniques are able to generate fetal-
Bin Li, Hui Yang, Xiaochen Wang, Yongkun Zhan, Wei Sheng, Huanhuan Cai, Haoyang Xin, Qianqian Liang, Ping Zhou, Chao Lu, Ruizhe Qian, Sifeng Chen, Pengyuan Yang, Jianyi Zhang, Weinian Shou, Guoying Huang, Ping Liang, Ning Sun   +17 more
doaj   +1 more source

High-Throughput Drug Screening System Based on Human Induced Pluripotent Stem Cell-Derived Atrial Myocytes ∼ A Novel Platform to Detect Cardiac Toxicity for Atrial Arrhythmias

Frontiers in Pharmacology, 2021
Evaluation of proarrhythmic properties is critical for drug discovery. In particular, QT prolongation in electrocardiograms has been utilized as a surrogate marker in many evaluation systems to assess the risk of torsade de pointes and lethal ventricular
Yayoi Honda, Yayoi Honda, Jun Li, Jun Li, Aya Hino, Shinji Tsujimoto, Jong-Kook Lee   +6 more
doaj   +1 more source

Mena/VASP and αII-Spectrin complexes regulate cytoplasmic actin networks in cardiomyocytes and protect from conduction abnormalities and dilated cardiomyopathy [PDF]

, 2013
BACKGROUND: In the heart, cytoplasmic actin networks are thought to have important roles in mechanical support, myofibrillogenesis, and ion channel function.
Benz, PM, Frantz, Stefan, Merkel, CJ, Offner, Kristin, Fleming, Ingrid, Feller, Stephan M., Renné, T, Gambaryan, Stepan, Unger, A, Linke, Wolfgang A., Fischer, T, Merkel, Carla J., Bayer, B, Schuh, K, Benz, Peter M., Wagner, Helga, Ullrich, Melanie, Linke, WA, Bayer, Barbara, Ullrich, M, Offner, K, Renné, Thomas, Abeßer, M, Ursitti, Jeanine A., Frantz, S, Adham, Ibrahim M., Unger, Andreas, Adham, IM, Feller, SM, Fischer, Tobias, Wagner, H, Abeßer, Marco, Schuh, Kai, Gambaryan, S, Fleming, I, Ursitti, JA   +35 more
core   +1 more source

Contribution of bone marrow-derived hematopoietic stem/progenitor cells to the generation of donor-marker⁺ cardiomyocytes in vivo. [PDF]

PLoS ONE, 2013
BACKGROUND: Definite identification of the cell types and the mechanism relevant to cardiomyogenesis is essential for effective cardiac regenerative medicine.
Mitsuhiro Fukata, Fumihiko Ishikawa, Yuho Najima, Takuji Yamauchi, Yoriko Saito, Katsuto Takenaka, Kohta Miyawaki, Hideki Shimazu, Kazuya Shimoda, Takaaki Kanemaru, Kei-Ichiro Nakamura, Keita Odashiro, Koji Nagafuji, Mine Harada, Koichi Akashi   +14 more
doaj   +1 more source

Consensus Comparative Analysis of Human Embryonic Stem Cell-Derived Cardiomyocytes [PDF]

, 2015
Global transcriptional analyses have been performed with human embryonic stem cells (hESC) derived cardiomyocytes (CMs) to identify molecules and pathways important for human CM differentiation, but variations in culture and profiling conditions have led
Ellen Poon (474693), Hau-San Wong (181512), Kenneth R Boheler, Li, RA, Ellen Poon, Boheler, KR, Ronald A Li, Shaohong Zhang, Dongqing Xie (734694), Zhang, SH, Ronald A. Li (75921), Shaohong Zhang (474694), Kenneth R. Boheler (75926), Hau-San Wong, Poon, E, Xie, D, Dongqing Xie, Wong, HS   +17 more
core   +2 more sources

Stimulation of Cardiomyocyte Proliferation Is Dependent on Species and Level of Maturation

Frontiers in Cell and Developmental Biology, 2022
The heart is one of the least regenerative organs. This is in large part due to the inability of adult mammalian cardiomyocytes to proliferate and divide.
Dogacan Yücel, Dogacan Yücel, Bayardo I. Garay, Bayardo I. Garay, Bayardo I. Garay, Rita C. R. Perlingeiro, Rita C. R. Perlingeiro, Rita C. R. Perlingeiro, Rita C. R. Perlingeiro, Jop H. van Berlo, Jop H. van Berlo, Jop H. van Berlo   +11 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Peroxisomes contribute to intracellular calcium dynamics in cardiomyocytes and non-excitable cells

Life Science Alliance, 2021
Using genetically encoded Förster resonance energy transfer calcium sensors for the peroxisome, this study dissects the previously contentious peroxisome involvement in calcium handling in HeLa cells and in cardiomyocytes derived from human induced ...
Yelena Sargsyan, Uta Bickmeyer, Christine S Gibhardt, Katrin Streckfuss-Bömeke, Ivan Bogeski, Sven Thoms   +5 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Adiponectin is synthesized and secreted by human and murine cardiomyocytes [PDF]

, 2005
Adiponectin is thought to play a decisive role in the relationships among obesity, insulin resistance and cardiovascular risk. This study investigated whether cardiomyocytes synthesize and secrete adiponectin, and the effects of this hormone on cardiac ...
Piñeiro, Roberto, Raghay, Kawtar, Diéguez, Carlos, Rosalía Gallego, Oreste Gualillo, José R. González-Juanatey, Francisca Lago, María J. Iglesias, José Rubio, Roberto Piñeiro, Iglesias, María J., Gualillo, Oreste, González-Juanatey, José R., Gallego, Rosalía, Rubio, José, Lago, Francisca, Sonia Eiras, Eiras, Sonia, Kawtar Raghay, Carlos Diéguez   +19 more
core   +1 more source