Results 61 to 70 of about 113,516 (292)

Engineering human ventricular heart muscles based on a highly efficient system for purification of human pluripotent stem cell-derived ventricular cardiomyocytes

Stem Cell Research & Therapy, 2017
Background Most infarctions occur in the left anterior descending coronary artery and cause myocardium damage of the left ventricle. Although current pluripotent stem cells (PSCs) and directed cardiac differentiation techniques are able to generate fetal-
Bin Li, Hui Yang, Xiaochen Wang, Yongkun Zhan, Wei Sheng, Huanhuan Cai, Haoyang Xin, Qianqian Liang, Ping Zhou, Chao Lu, Ruizhe Qian, Sifeng Chen, Pengyuan Yang, Jianyi Zhang, Weinian Shou, Guoying Huang, Ping Liang, Ning Sun   +17 more
doaj   +1 more source

High-Throughput Drug Screening System Based on Human Induced Pluripotent Stem Cell-Derived Atrial Myocytes ∼ A Novel Platform to Detect Cardiac Toxicity for Atrial Arrhythmias

Frontiers in Pharmacology, 2021
Evaluation of proarrhythmic properties is critical for drug discovery. In particular, QT prolongation in electrocardiograms has been utilized as a surrogate marker in many evaluation systems to assess the risk of torsade de pointes and lethal ventricular
Yayoi Honda, Yayoi Honda, Jun Li, Jun Li, Aya Hino, Shinji Tsujimoto, Jong-Kook Lee   +6 more
doaj   +1 more source

Cardiomyocyte Regeneration in Human Myocarditis

European Heart Journal
Background : Newly generated cardiomyocytes (NGC) concur to recovery of human myocarditis. However, Methods: We retrospectively assessed NGC in 213 consecutive patients with endomyocardial biopsy denoting acute myocarditis, with normal coronaries and valves.
Andrea Frustaci, Eleonora Foglio, Federica Limana, Michele Magnocavallo, Emanuela Frustaci, Leonardo Lupacchini, Romina Verardo   +6 more
openaire   +3 more sources

Dating the Heart: Exploring Cardiomyocyte Renewal in Humans [PDF]

Physiology, 2017
Regenerative mechanisms reported in the hearts of lower vertebrates have been recapitulated in the mammalian milieu, and recent studies have provided strong evidence for cardiomyocyte turnover in humans. These findings speak to an emerging consensus that adult mammalian cardiomyocytes do have the ability to divide, and it stands to reason that ...
Evan, Graham, Olaf, Bergmann
openaire   +2 more sources

Differentiation of Cardiomyocytes from Human Pluripotent Stem Cells Using Monolayer Culture

, 2015
Human pluripotent stem cells (PSCs) are a promising cell source for cardiac tissue engineering and cell-based therapies for heart repair because they can be expanded in vitro and differentiated into most cardiovascular cell types, including ...
Ivan Batalov, Adam W. Feinberg
core   +1 more source

Mena/VASP and αII-Spectrin complexes regulate cytoplasmic actin networks in cardiomyocytes and protect from conduction abnormalities and dilated cardiomyopathy [PDF]

, 2013
BACKGROUND: In the heart, cytoplasmic actin networks are thought to have important roles in mechanical support, myofibrillogenesis, and ion channel function.
Benz, PM, Frantz, Stefan, Merkel, CJ, Offner, Kristin, Fleming, Ingrid, Feller, Stephan M., Renné, T, Gambaryan, Stepan, Unger, A, Linke, Wolfgang A., Fischer, T, Merkel, Carla J., Bayer, B, Schuh, K, Benz, Peter M., Wagner, Helga, Ullrich, Melanie, Linke, WA, Bayer, Barbara, Ullrich, M, Offner, K, Renné, Thomas, Abeßer, M, Ursitti, Jeanine A., Frantz, S, Adham, Ibrahim M., Unger, Andreas, Adham, IM, Feller, SM, Fischer, Tobias, Wagner, H, Abeßer, Marco, Schuh, Kai, Gambaryan, S, Fleming, I, Ursitti, JA   +35 more
core   +1 more source

MicroRNA-197-3p Transfection: Variations in Cardiomyocyte Gene Expression with Anaesthetics Drugs in a Model of Hypoxia/Reperfusion

Pharmaceuticals
Background: Our research team analyzed the microRNA (miRNA)-197-3p involved in cardioprotection, and we demonstrated that the overexpression of miRNA-197-3p could be linked to a higher risk of cardiac damage.
Jose Luis Guerrero-Orriach, Maria Dolores Carmona-Luque, Maria Jose Rodriguez-Capitan, Guillermo Quesada-Muñoz   +3 more
doaj   +1 more source

Contribution of bone marrow-derived hematopoietic stem/progenitor cells to the generation of donor-marker⁺ cardiomyocytes in vivo. [PDF]

PLoS ONE, 2013
BACKGROUND: Definite identification of the cell types and the mechanism relevant to cardiomyogenesis is essential for effective cardiac regenerative medicine.
Mitsuhiro Fukata, Fumihiko Ishikawa, Yuho Najima, Takuji Yamauchi, Yoriko Saito, Katsuto Takenaka, Kohta Miyawaki, Hideki Shimazu, Kazuya Shimoda, Takaaki Kanemaru, Kei-Ichiro Nakamura, Keita Odashiro, Koji Nagafuji, Mine Harada, Koichi Akashi   +14 more
doaj   +1 more source

Stimulation of Cardiomyocyte Proliferation Is Dependent on Species and Level of Maturation

Frontiers in Cell and Developmental Biology, 2022
The heart is one of the least regenerative organs. This is in large part due to the inability of adult mammalian cardiomyocytes to proliferate and divide.
Dogacan Yücel, Dogacan Yücel, Bayardo I. Garay, Bayardo I. Garay, Bayardo I. Garay, Rita C. R. Perlingeiro, Rita C. R. Perlingeiro, Rita C. R. Perlingeiro, Rita C. R. Perlingeiro, Jop H. van Berlo, Jop H. van Berlo, Jop H. van Berlo   +11 more
doaj   +1 more source

Centrosome Reduction Promotes Terminal Differentiation of Human Cardiomyocytes [PDF]

Stem Cell Reports, 2020
Centrosome reduction and redistribution of pericentriolar material (PCM) coincides with cardiomyocyte transitions to a post-mitotic and matured state. However, it is unclear whether centrosome changes are a cause or consequence of terminal differentiation.
Ng, Dominic C.H., Richards, Dominic K., Mills, Richard J., Ho, Uda Y., Perks, Hannah L., Tucker, Callum R., Voges, Holly K., Pagan, Julia K., Hudson, James E.   +8 more
openaire   +5 more sources