Results 51 to 60 of about 113,516 (292)

The Effect of TWIK-1 Two Pore Potassium Channels on Cardiomyocytes in Low Extracellular Potassium Conditions

Frontiers in Bioscience-Landmark, 2023
Backgroound: At low extracellular potassium ([K+]e) conditions, human cardiomyocytes can depolarize to –40 mV. This is closely related to hypokalemia-induced fatal cardiac arrhythmia. The underlying mechanism, however, is still not well understood.
Ping Liu, Yawen Yang, Hengxi Zhang, Yingying Zhang, Jin Zeng, Dongchuan Zuo   +5 more
doaj   +1 more source

Development and characterization of a scaffold-free 3D spheroid model of iPSC-derived human cardiomyocytes [PDF]

, 2015
Purpose: Cardiomyocytes are terminally differentiated cells in the adult heart and ischemia and cardiotoxic compounds can lead to cell death and irreversible decline of cardiac function.
Beauchamp, Philippe, Anson, Blake, Moritz, Wolfgang, Suter, Thomas, Zuppinger, Christian, Jens, Kelm, Ullrich, Nina, Agarkova, Irina   +7 more
core   +1 more source

HIV-1 subtype C unproductively infects human cardiomyocytes in vitro and induces apoptosis mitigated by an anti-Gp120 aptamer. [PDF]

PLoS ONE, 2014
HIV-associated cardiomyopathy (HIVCM) is of clinical concern in developing countries because of a high HIV-1 prevalence, especially subtype C, and limited access to highly active antiretroviral therapy (HAART).
Walter R Lopes de Campos, Nthato Chirwa, Grace London, Lia S Rotherham, Lynn Morris, Bongani M Mayosi, Makobetsa Khati   +6 more
doaj   +1 more source

Enhanced nanomagnetic gene transfection of human prenatal cardiac progenitor cells and adult cardiomyocytes [PDF]

, 2013
Magnetic nanoparticle-based gene transfection has been shown to be an effective, non-viral technique for delivery of both plasmid DNA and siRNA into cells in culture.
Jon Dobson, Subramanian, Mahendran, Dobson, John, Mahendran Subramanian, Lim, Jenson, Jenson Lim, Dobson, Jon   +6 more
core   +1 more source

Iron Depletion Affects Genes Encoding Mitochondrial Electron Transport Chain and Genes of Non­Oxidative Metabolism, Pyruvate Kinase and Lactate Dehydrogenase, in Primary Human Cardiac Myocytes Cultured upon Mechanical Stretch

Cells, 2018
(1) Background: Oxidative energy metabolism is presumed to rely on the optimal iron supply. Primary human cardiac myocytes (HCM) exposed to different iron availability conditions during mechanical stretch are anticipated to demonstrate expression changes
Magdalena Dziegala, Kamil A. Kobak, Monika Kasztura, Jacek Bania, Krystian Josiak, Waldemar Banasiak, Piotr Ponikowski, Ewa A. Jankowska   +7 more
doaj   +1 more source

Generation of mature compact ventricular cardiomyocytes from human pluripotent stem cells

Nature Communications, 2021
Cardiomyocytes of heart ventricles consist of subpopulations of trabecular and compact subtypes. Here the authors describe the generation of structurally, metabolically and functionally mature compact ventricular cardiomyocytes as well as mature atrial ...
Shunsuke Funakoshi, Ian Fernandes, Olya Mastikhina, Dan Wilkinson, Thinh Tran, Wahiba Dhahri, Amine Mazine, Donghe Yang, Benjamin Burnett, Jeehoon Lee, Stephanie Protze, Gary D. Bader, Sara S. Nunes, Michael Laflamme, Gordon Keller   +14 more
doaj   +1 more source

A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease

Circulation, 2023
BACKGROUND: Cardiomyocytes in the adult human heart show a regenerative capacity, with an annual renewal rate of ≈0.5%. Whether this regenerative capacity of human cardiomyocytes is employed in heart failure has been controversial. METHODS:
Wouter Derks, Julian Rode, Sofia Collin, Fabian Rost, Paula Heinke, Anjana Hariharan, Lauren Pickel, Irina Simonova, Enikő Lázár, Evan Graham, Ramadan Jashari, Michaela Andrä, Anders Jeppsson, Mehran Salehpour, Kanar Alkass, Henrik Druid, Christos P. Kyriakopoulos, Iosif Taleb, Thirupura S. Shankar, Craig H. Selzman, Hesham Sadek, Stefan Jovinge, Lutz Brusch, Jonas Frisén, Stavros Drakos, Olaf Bergmann   +25 more
openaire   +5 more sources

Consensus Comparative Analysis of Human Embryonic Stem Cell-Derived Cardiomyocytes [PDF]

, 2015
Global transcriptional analyses have been performed with human embryonic stem cells (hESC) derived cardiomyocytes (CMs) to identify molecules and pathways important for human CM differentiation, but variations in culture and profiling conditions have led
Ellen Poon (474693), Hau-San Wong (181512), Kenneth R Boheler, Li, RA, Ellen Poon, Boheler, KR, Ronald A Li, Shaohong Zhang, Dongqing Xie (734694), Zhang, SH, Ronald A. Li (75921), Shaohong Zhang (474694), Kenneth R. Boheler (75926), Hau-San Wong, Poon, E, Xie, D, Dongqing Xie, Wong, HS   +17 more
core   +1 more source

In-silico analysis of aging mechanisms of action potential remodeling in human atrial cardiomyocites

BIO Web of Conferences, 2020
Electrophysiology of cardiomyocytes changes with aging. Agerelated ionic remodeling in cardiomyocytes may increase the incidence and prevalence of atrial fibrillation (AF) in the elderly and affect the efficiency of antiarrhythmic drugs.
Nesterova Tatyana, Shmarko Dmitry, Ushenin Konstantin, Solovyova Olga   +3 more
doaj   +1 more source

Transdifferentiation of blood-derived human adult endothelial progenitor cells into functionally active cardiomyocytes

, 2003
Background - Further to promoting angiogenesis, cell therapy may be an approach for cardiac regeneration. Recent studies suggest that progenitor cells can transdifferentiate into other lineages. However, the transdifferentiation potential of endothelial
Dimmeler, S, Aicher, A, Popp, R, Urbich, C, Busse, R, Badorff, C, Brandes, RP, Fleming, I, Zeiher, AM, Rupp, S   +9 more
core   +1 more source