Results 51 to 60 of about 9,526,153 (337)

Inhibition of miR-128-3p by Tongxinluo Protects Human Cardiomyocytes from Ischemia/reperfusion Injury via Upregulation of p70s6k1/p-p70s6k1

Frontiers in Pharmacology, 2017
Background and Aims: Tongxinluo (TXL) is a multifunctional traditional Chinese medicine that has been widely used to treat cardiovascular and cerebrovascular diseases.
Gui-hao Chen, Chuan-sheng Xu, Jie Zhang, Qing Li, He-he Cui, Xiang-dong Li, Li-ping Chang, Rui-jie Tang, Jun-yan Xu, Xia-qiu Tian, Pei-sen Huang, Jun Xu, Chen Jin, Yue-jin Yang   +13 more
doaj   +1 more source

Transdifferentiation of blood-derived human adult endothelial progenitor cells into functionally active cardiomyocytes [PDF]

, 2003
Background - Further to promoting angiogenesis, cell therapy may be an approach for cardiac regeneration. Recent studies suggest that progenitor cells can transdifferentiate into other lineages. However, the transdifferentiation potential of endothelial
Aicher, A, Badorff, C, Brandes, RP, Busse, R, Dimmeler, S, Fleming, I, Popp, R, Rupp, S, Urbich, C, Zeiher, AM   +9 more
core   +1 more source

Identification of murine phosphodiesterase 5A isoforms and their functional characterization in HL-1 cardiac cell line [PDF]

, 2017
Phosphodiesterase 5A (PDE5A) specifically degrades the ubiquitous second messenger cGMP and experimental and clinical data highlight its important role in cardiac diseases.
Barbagallo, Federica, Campolo, Federica, Cardarelli, Silvia, Cornacchione, Marisa, DE ARCANGELIS, Valeria, DI GRAZIA, Antonio, Gianfrilli, Daniele, Giorgi, Mauro, Isidori, Andrea, Lenzi, Andrea, Monaco, Lucia, Naro, Fabio, Pellegrini, Manuela, Zevini, Alessandra   +13 more
core   +1 more source

Adenine Nucleotide Translocase 1 Expression is Coupled to the HSP27-Mediated TLR4 Signaling in Cardiomyocytes [PDF]

, 2019
The cardiac-specific overexpression of the adenine nucleotide translocase 1 (ANT1) has cardioprotective effects in various experimental heart disease models.
Dörner, Andrea, Hammer, Elke, Heger, Jacqueline, Landmesser, Ulf, Rauch, Ursula, Schultheiss, Heinz-Peter, Winter, Julia   +6 more
core   +2 more sources

Cardiac stem cells: A promising treatment option for heart failure. [PDF]

, 2012
Cardiovascular diseases are the most common cause of death in the world. The development of heart failure is mainly due to the loss of cardiomyocytes following myocardial infarction and the absence of endogenous myocardial repair.
Huang, Lan, Zhao, Xiaohui
core   +1 more source

The Effect of TWIK-1 Two Pore Potassium Channels on Cardiomyocytes in Low Extracellular Potassium Conditions

Frontiers in Bioscience-Landmark, 2023
Backgroound: At low extracellular potassium ([K+]e) conditions, human cardiomyocytes can depolarize to –40 mV. This is closely related to hypokalemia-induced fatal cardiac arrhythmia. The underlying mechanism, however, is still not well understood.
Ping Liu, Yawen Yang, Hengxi Zhang, Yingying Zhang, Jin Zeng, Dongchuan Zuo   +5 more
doaj   +1 more source

Comprehensive translational assessment of human-induced pluripotent stem cell derived cardiomyocytes for evaluating drug-induced arrhythmias [PDF]

, 2016
Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) hold promise for assessment of drug-induced arrhythmias and are being considered for use under the comprehensive in vitro proarrhythmia assay (CiPA).
Blinova, Ksenia, Brock, Mathew, Chan, Dulciana, Chvatal, Stacie, Crumb, William J., Galeotti, Loriano, Hortigon-Vinagre, Maria P., Johannesen, Lars, Lyn-Cook, Beverly, Millard, Daniel, Pang, Li, Ross, James, Smith, Godfrey, Stockbridge, Norman, Stohlman, Jayna, Strauss, David G., Vicente, Jose, Zamora Rodriguez, Victor   +17 more
core   +1 more source

Iron deficiency impairs contractility of human cardiomyocytes through decreased mitochondrial function

European Journal of Heart Failure, 2018
Iron deficiency is common in patients with heart failure and associated with a poor cardiac function and higher mortality. How iron deficiency impairs cardiac function on a cellular level in the human setting is unknown.
M. Hoes, N. Grote Beverborg, J. D. Kijlstra, J. Kuipers, D. Swinkels, B. Giepmans, R. Rodenburg, D. V. van Veldhuisen, R. D. de Boer, P. van der Meer   +9 more
semanticscholar   +1 more source

Mutation location of HCM-causing troponin T mutations defines the degree of myofilament dysfunction in human cardiomyocytes

Journal of Molecular and Cellular Cardiology, 2020
Background: The clinical outcome of hypertrophic cardiomyopathy patients is not only determined by the disease-causing mutation but influenced by a variety of disease modifiers.
M. Schuldt, Jamie R Johnston, Huan He, R. Huurman, J. Pei, M. Harakalova, C. Poggesi, M. Michels, D. Kuster, J. Pinto, J. van der Velden   +10 more
semanticscholar   +1 more source

Activin-A and Bmp4 Levels Modulate Cell Type Specification during CHIR-Induced Cardiomyogenesis [PDF]

, 2015
The use of human pluripotent cell progeny for cardiac disease modeling, drug testing and therapeutics requires the ability to efficiently induce pluripotent cells into the cardiomyogenic lineage.
Blinka, Steven, Gundry, Rebekah, Horst, Audrey, Kim, Min-Su, Lough, John, Mahnke, Donna K., Schuman, James, Stamm, Karl D., Tomita-Mitchell, Aoy   +8 more
core   +8 more sources