Results 51 to 60 of about 7,574,392 (244)

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

Advanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi, Ludovic Mouttet, Shihao Cui, Yasaman Hekmatnia, Mehran Mottahedi, Ida Derish, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Renzo Cecere, Houman Savoji   +10 more
wiley   +1 more source

Merits of hiPSC-Derived Cardiomyocytes for In Vitro Research and Testing Drug Toxicity

Biomedicines, 2022
The progress of medical technology and scientific advances in the field of anticancer treatment have increased the survival probabilities and duration of life of patients.
Ping-Hsien Wang, Yi-Hsien Fang, Yen-Wen Liu, Min-Long Yeh   +3 more
doaj   +1 more source

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

In silico predictions of drug-induced changes in human cardiac contractility align with experimental recordings

Frontiers in Pharmacology
Drug-induced changes in cardiac contractility (inotropy) can lead to cardiotoxicity, a major cause of discontinuation in drug development. Preclinical approaches to assess cardiac inotropy are imperfect, with in vitro assays limited to stem cell-derived ...
Cristian Trovato, Cristian Trovato, Stefano Longobardi, Elisa Passini, Kylie A. Beattie, Maxx Holmes, Khuram W. Chaudhary, Eric I. Rossman, Blanca Rodriguez   +8 more
doaj   +1 more source

Calcium Homeostasis in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes [PDF]

, 2011
Rationale: Cardiomyocytes generated from human induced pluripotent stem cells (hiPSCs) are suggested as the most promising candidate to replenish cardiomyocyte loss in regenerative medicine.
Lai, WH, Lian, Q, Lee, Yee-Ki, Lee, YK, Yau-Chi Chan, Kwong-Man Ng, Qizhou Lian, Lau, YM, Chung-Wah Siu, Hung-Fat Tse, Chan, YC, Siu, CW, Yee-Man Lau, ux through L-type calci Chung-Wah Siu, Yee-Ki Lee, Tse, HF, Ng, KM, Wing-Hon Lai   +17 more
core   +1 more source

Optical Detection of Cellular Signals at Material Interfaces

Advanced Healthcare Materials, EarlyView.
Emerging functional materials are transforming optical detection of cellular signals. This review highlights optical techniques that exploit the unique optical properties of diverse materials to detect and quantify cellular electrical, chemical, and mechanical signals, and discusses key opportunities and challenges.
Xuchen Ren, Jitong Ren, Zixin Zhang, Koney Eungkon Kim, Francis L. Hong, Yuecheng Peter Zhou   +5 more
wiley   +1 more source

Phenotyping cultured human cardiomyocytes.

, 2014
Human cardiomyocytes cultured on microscope cover slips where phenotyped using cardiac markers (A) α-MHC (63× magnification) (AF546-labeled secondary antibody [red]) (B) Cx43 (x40) (AF488-labeled primary antibody [green]) and (C) cTnT (40× magnification)
Lynn Morris (7883), Walter R. Lopes de Campos (646288), Lia S. Rotherham (129222), Makobetsa Khati (129233), Grace London (646290), Bongani M. Mayosi (202901), Nthato Chirwa (646289)   +6 more
core   +1 more source

Atrial cardiomyocytes development from human induced pluripotent stem cells [PDF]

, 2018
Cardiovascular diseases are the leading cause of death around the globe. Despite ongoing progress, a shortage in the primary source of human cardiac tissue still presents a major limiting factor in relevant research. Human induced pluripotent stem cells (
Meng Yuan, Yuan, Meng
core   +1 more source

Soft Skins With Reversible Thickness Morphing: Materials, Mechanisms, and Applications

Advanced Materials, EarlyView.
Evolution of electronic skin (e‐skin) technologies toward adaptive, multifunctional soft skins. Phase I highlights early rigid and discrete sensory interfaces. Phase II shows the transition toward flexible, stretchable, and large‐area e‐skin. Phase III captures the emergence of computational e‐skin.
Oliver Ozioko, Chiamaka Akah, Ravinder Dahiya   +2 more
wiley   +1 more source

Elastomeric 3D‐Printed Microenvironments Enable Nanonewton Force Measurements in Healthy and Diseased Human Pluripotent Stem Cell‐Derived Neuroepithelial Cells

Advanced Materials, EarlyView.
We present elastomeric three‐dimensional (3D) microstructures fabricated via two‐photon polymerization (2PP) and post‐processed through wet etching, for quantifying nanonewton (nN)‐scale forces applied by healthy and diseased neural cells. The mechanically characterized free‐standing beam architectures enable measurement of traction forces of ...
Pieter F. J. van Altena, Lucia Castillo Ransanz, Ruben H. Guis, Giulia Bergamaschi, Nanne J. Paauw, Urs Staufer, Vivi M. Heine, Angelo Accardo   +7 more
wiley   +1 more source