Results 71 to 80 of about 7,574,392 (244)

In vitro epigenetic reprogramming of human cardiac mesenchymal stromal cells into functionally competent cardiovascular precursors [PDF]

, 2012
Adult human cardiac mesenchymal-like stromal cells (CStC) represent a relatively accessible cell type useful for therapy. In this light, their conversion into cardiovascular precursors represents a potential successful strategy for cardiac repair.
Andrea Barbuti (106295), A. Barbuti, Rossini, Alessandra, Simona Nanni, Nanni, Simona, Barbuti, Andrea, C. Gaetano, Meraviglia Viviana, Carlo Gaetano (110837), Meraviglia, Viviana, Capogrossi, Maurizio C., Pompilio Giulio, Gualtiero I Colombo, Angela Scavone, Simona Nanni (110816), Maurizio C Capogrossi, S. Nanni, Scavone Angela, Matteo Vecellio, Viviana Meraviglia (110811), DiFrancesco Dario, A. Scavone, Antonella Farsetti, Alessandra Rossini (110841), Viviana Meraviglia, Colombo Gualtiero I., Dario DiFrancesco, Pompilio, Giulio, Gaetano, Carlo, Vecellio, Matteo, Nanni Simona, Maurizio C. Capogrossi (103525), D. DiFrancesco, Giulio Pompilio (103510), Gaetano Carlo, Carlo Gaetano, Colombo, Gualtiero I., Vecellio Matteo, Farsetti Antonella, A. Farsetti, Angela Scavone (110822), M. Vecellio, Farsetti, Antonella, Barbuti Andrea, Capogrossi Maurizio C., Rossini Alessandra, G.I. Colombo, Giulio Pompilio, Antonella Farsetti (110827), V. Meraviglia, Alessandra Rossini, Andrea Barbuti, DiFrancesco, Dario, Dario DiFrancesco (106304), M. C. Capogrossi, Gualtiero I. Colombo (103516), Scavone, Angela, Matteo Vecellio (110807), A. Rossini, G. Pompilio   +59 more
core   +2 more sources

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Derivation of human post-mitotic cardiomyocytes from tetraploid iPSCs

Communications Biology
Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (iPS-CMs) have great potential in regenerative medicine. However, iPS-CMs are immature and resemble fetal cardiomyocytes, restricting their application.
Ittetsu Nakajima, Mitsuyoshi Shimane, Grace Holmstrom, Yuichiro Miyaoka   +3 more
doaj   +1 more source

Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes

Frontiers in Pharmacology, 2019
Contractility of the myocardium engines the pumping function of the heart and is enabled by the collective contractile activity of its muscle cells: cardiomyocytes.
Alexandre J. S. Ribeiro, Brian D. Guth, Brian D. Guth, Michael Engwall, Sandy Eldridge, C. Michael Foley, Liang Guo, Gary Gintant, John Koerner, Stanley T. Parish, Jennifer B. Pierson, Mathew Brock, Khuram W. Chaudhary, Yasunari Kanda, Brian Berridge   +14 more
doaj   +1 more source

Large-scale production of cardiomyocytes from human pluripotent stem cells using a highly reproducible small molecule-based differentiation protocol

, 2016
Maximizing the benefit of human pluripotent stem cells (hPSCs) for research, disease modeling, pharmaceutical and clinical applications requires robust methods for the large-scale production of functional cell types, including cardiomyocytes.
Aghdami, N, Harvey, RP, Bosman, A, Baharvand, H, Ansari, H, Winlaw, DS, Fonoudi, H, Abbasalizadeh, S, Blue, GM   +8 more
core   +1 more source

Cyclic Mechanical Loading of Cardiomyocytes via Pressure‐Driven Non‐Planar Membrane Deformation in a Bioreactor System

Advanced Science, EarlyView.
In this research article, Mansoor and coworkers present a novel device that applies controlled mechanical stimuli to cardiomyocytes using pressure‐driven membrane deformation. By exposing cells to physiologically and pathologically relevant loading conditions, the platform reproduces distinct structural, functional and molecular responses associated ...
Haris Mansoor, Gabrielle Juul, Jil Patel, Heran Pradhan, Gram Hepner, Jackson Jewell, Mark Bardin, Ryan Slusser, Abigail Glezer, Leda Klouda, Melikhan Tanyeri, Anita Saraf   +11 more
wiley   +1 more source

The Critical Human Rights Issues of 2022: Year in Review

, 2023
AAs 2022 draws to a close, the Carr Center and its affiliates are reflecting on events and issues around the world that continue to shape our approach to protecting human rights.
Carr Center for Human Rights Policy
core   +3 more sources

Increased Nox2 expression in human cardiomyocytes after acute myocardial infarction

, 2003
Background/Aims: Recent studies indicate the presence of reactive oxygen species (ROS) producing homologues of the enzymatic subunit (Nox2) of phagocytic NADPH oxidase in non-phagocytic cells.
Meijer, C. J. L. M., Visser, C A, Hack, C. E., Meischl, C., Niessen, H. W. M., Krijnen, P A J, Meijer, C J L M, Meischl, C, Niessen, H W M, Roos, D, Roos, D., Krijnen, P. A. J., Visser, C. A., Hack, C E   +13 more
core   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Intermittent Fasting Restores Cardiac Lipid Homeostasis in Diabetic Cardiomyopathy in Association With Akkermansia Muciniphila and 1‐methyl‐L‐histidine

Advanced Science, EarlyView.
Intermittent fasting reshapes the gut microbiota in diabetic cardiomyopathy, restoring Akkermansia muciniphila and the microbiota‐associated metabolite 1‐methyl‐L‐histidine. This shift is linked to improved cardiac lipid homeostasis, reduced lipid peroxidation, and attenuated myocardial injury, highlighting a gut microbiota–metabolite–lipid axis in ...
Kaiyuan Jiang, Fen Xiong, Yiwen Peng, Lingfei Meng, Xinran Wang, Yingruo Xu, Tian Tang, Hongchang Gao   +7 more
wiley   +1 more source