Results 71 to 80 of about 113,516 (292)

Peroxisomes contribute to intracellular calcium dynamics in cardiomyocytes and non-excitable cells

Life Science Alliance, 2021
Using genetically encoded Förster resonance energy transfer calcium sensors for the peroxisome, this study dissects the previously contentious peroxisome involvement in calcium handling in HeLa cells and in cardiomyocytes derived from human induced ...
Yelena Sargsyan, Uta Bickmeyer, Christine S Gibhardt, Katrin Streckfuss-Bömeke, Ivan Bogeski, Sven Thoms   +5 more
doaj   +1 more source

S100A1 genetically targeted therapy reverses dysfunction of human failing cardiomyocytes

, 2011
This study investigated the hypothesis whether S100A1 gene therapy can improve pathological key features in human failing ventricular cardiomyocytes (HFCMs)
Thierry Carrel, Henriette Brinks, Most, Patrick, Eckhart, Andrea D., Walter J. Koch, Sven T. Pleger, Qiu, Gang, Pleger, Sven T, Carrel, Thierry, Koch, Walter J, Mather, Paul J, David Rohde, Katus, Hugo A, Joseph Rabinowitz, Hugo A. Katus, Andrea D. Eckhart, Paul J. Mather, Mirko Voelkers, Arjang Ruhparwar, Rohde, David, Herzog, Nicole, Pleger, Sven T., Brinks, Henriette, Nicole Herzog, Carolin Lerchenmüller, Patrick Most, Rabinowitz, Joseph, Silvestry, Scott, Gang Qiu, Eckhart, Andrea D, Mather, Paul J., Lerchenmüller, Carolin, Katus, Hugo A., Koch, Walter J., Voelkers, Mirko, Ruhparwar, Arjang, Scott Silvestry   +36 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Myofilament Degradation and Dysfunction of Human Cardiomyocytes in Fabry Disease [PDF]

The American Journal of Pathology, 2008
Early detection of myocardial dysfunction in Fabry disease (FD) cardiomyopathy suggests the contribution of myofilament structural alterations. Six males with untreated FD cardiomyopathy submitted to cardiac studies, including tissue Doppler imaging and left ventricular endomyocardial biopsy.
CHIMENTI, CRISTINA, HAMDANI H, BOONTJE NM, DECOBELLI F, ESPOSITO A, BRONZWAER JGF, STIENEN GJM, RUSSO, Matteo Antonio, PAULUS WJ, FRUSTACI, ANDREA, VAN DER VELDEN J.   +10 more
openaire   +4 more sources

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Loss-of-function of leptin receptor impairs metabolism in human cardiomyocytes

, 2023
Background and aims: Leptin resistance or leptin signalling deficiency are associated with increased risk of diabetic cardiomyopathy and heart failure, which is a leading cause of obesity- and diabetes type 2 (T2DM)-related morbidity and mortality ...
Strano, Anna
core   +2 more sources

Merits of hiPSC-Derived Cardiomyocytes for In Vitro Research and Testing Drug Toxicity

Biomedicines, 2022
The progress of medical technology and scientific advances in the field of anticancer treatment have increased the survival probabilities and duration of life of patients.
Ping-Hsien Wang, Yi-Hsien Fang, Yen-Wen Liu, Min-Long Yeh   +3 more
doaj   +1 more source

Slow Turning Lateral Vessel Bioreactor Improves Embryoid Body Formation and Cardiogenic Differentiation of Mouse Embryonic Stem Cells.

, 2013
Embryonic stem cells (ESCs) have the ability to form aggregates, which are called embryoid bodies (EBs). EBs mimic early embryonic development and are commonly produced for cardiomyogenesis.
Tharasanit, T., Biology of Reproductive Cells, Pirity, M., Rungarunlert, Sasitorn, Klincumhom, Nuttha, Rungarunlert, S., Dinnyés, András, Tharasanit, Theerawat, Dep Gezondheidszorg Landbouwhuisdieren, Klincumhom, N., Techakumphu, M., Pirity, Melinda, Dinnyes, A.   +12 more
core   +1 more source

Transfer Printing and Reconfiguration of Soft Electronics Using Digital Microfluidics and Laser Machining

Advanced Functional Materials, EarlyView.
This paper presents a digital microfluidics‐based technique for transferring and reconfiguring soft nanomembranes. Laser‐machined nanothin membranes are picked up, transported, and aligned via tailored surface tension and the actuation of water droplets, enabling the development of flexible electronics, the integration of functional materials on 3D ...
Quang Anh Nguyen, Chi Cong Nguyen, Tran Bach Dang, Phuoc Thien Phan, Jordan Thorpe, Michael Listyawan, Nhat Minh Doan, Sinuo Zhao, Hongru Chen, Trung Thien Hoang, Mingsheng Xu, Jisheng Han, Thanh Nho Do, Adam Hill, Timothée Mouterde, Hoang‐Phuong Phan   +15 more
wiley   +1 more source

Human Ventricular Unloading Induces Cardiomyocyte Proliferation

Journal of the American College of Cardiology, 2015
The adult mammalian heart is incapable of meaningful regeneration after substantial cardiomyocyte loss, primarily due to the inability of adult cardiomyocytes to divide. Our group recently showed that mitochondria-mediated oxidative DNA damage is an important regulator of postnatal cardiomyocyte cell cycle arrest.
Canseco, Diana C., Kimura, Wataru, Garg, Sonia, Mukherjee, Shibani, Bhattacharya, Souparno, Abdisalaam, Salim, Das, Sandeep, Asaithamby, Aroumougame, Mammen, Pradeep P.A., Sadek, Hesham A.   +9 more
openaire   +2 more sources