Results 71 to 80 of about 9,526,153 (337)

Depletion of Vasohibin 1 Speeds Contraction and Relaxation in Failing Human Cardiomyocytes

Circulation Research, 2020
Supplemental Digital Content is available in the text. Rationale: Impaired myocardial relaxation is an intractable feature of several heart failure (HF) causes. In human HF, detyrosinated microtubules stiffen cardiomyocytes and impair relaxation. Yet the
C. Y. Chen, A. K. Salomon, M. Caporizzo, S. Curry, N. Kelly, K. Bedi, A. Bogush, Elisabeth Krämer, S. Schlossarek, P. Janiak, M. Moutin, L. Carrier, K. Margulies, B. Prosser   +13 more
semanticscholar   +1 more source

High-Throughput Drug Screening System Based on Human Induced Pluripotent Stem Cell-Derived Atrial Myocytes ∼ A Novel Platform to Detect Cardiac Toxicity for Atrial Arrhythmias

Frontiers in Pharmacology, 2021
Evaluation of proarrhythmic properties is critical for drug discovery. In particular, QT prolongation in electrocardiograms has been utilized as a surrogate marker in many evaluation systems to assess the risk of torsade de pointes and lethal ventricular
Yayoi Honda, Yayoi Honda, Jun Li, Jun Li, Aya Hino, Shinji Tsujimoto, Jong-Kook Lee   +6 more
doaj   +1 more source

TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes

Nature Communications, 2019
Mitochondrial trifunctional protein deficiency, due to mutations in hydratase subunit A (HADHA), results in sudden infant death syndrome with no cure.
J. Miklas, Elisa Clark, Shiri Levy, Damien Detraux, Andrea Leonard, Kevin M. Beussman, Megan Showalter, Alec T. Smith, Peter Hofsteen, Xiulan Yang, J. Macadangdang, T. Manninen, D. Raftery, A. Madan, A. Suomalainen, Deok‐Ho Kim, C. Murry, O. Fiehn, N. Sniadecki, Yuliang Wang, H. Ruohola-Baker   +20 more
semanticscholar   +1 more source

Cardiomyocyte Regeneration in Human Myocarditis

European Heart Journal
Background : Newly generated cardiomyocytes (NGC) concur to recovery of human myocarditis. However, Methods: We retrospectively assessed NGC in 213 consecutive patients with endomyocardial biopsy denoting acute myocarditis, with normal coronaries and valves.
Andrea Frustaci, Eleonora Foglio, Federica Limana, Michele Magnocavallo, Emanuela Frustaci, Leonardo Lupacchini, Romina Verardo   +6 more
openaire   +3 more sources

MicroRNA-197-3p Transfection: Variations in Cardiomyocyte Gene Expression with Anaesthetics Drugs in a Model of Hypoxia/Reperfusion

Pharmaceuticals
Background: Our research team analyzed the microRNA (miRNA)-197-3p involved in cardioprotection, and we demonstrated that the overexpression of miRNA-197-3p could be linked to a higher risk of cardiac damage.
Jose Luis Guerrero-Orriach, Maria Dolores Carmona-Luque, Maria Jose Rodriguez-Capitan, Guillermo Quesada-Muñoz   +3 more
doaj   +1 more source

Engineering human ventricular heart muscles based on a highly efficient system for purification of human pluripotent stem cell-derived ventricular cardiomyocytes

Stem Cell Research & Therapy, 2017
Background Most infarctions occur in the left anterior descending coronary artery and cause myocardium damage of the left ventricle. Although current pluripotent stem cells (PSCs) and directed cardiac differentiation techniques are able to generate fetal-
Bin Li, Hui Yang, Xiaochen Wang, Yongkun Zhan, Wei Sheng, Huanhuan Cai, Haoyang Xin, Qianqian Liang, Ping Zhou, Chao Lu, Ruizhe Qian, Sifeng Chen, Pengyuan Yang, Jianyi Zhang, Weinian Shou, Guoying Huang, Ping Liang, Ning Sun   +17 more
doaj   +1 more source

Contribution of bone marrow-derived hematopoietic stem/progenitor cells to the generation of donor-marker⁺ cardiomyocytes in vivo. [PDF]

PLoS ONE, 2013
BACKGROUND: Definite identification of the cell types and the mechanism relevant to cardiomyogenesis is essential for effective cardiac regenerative medicine.
Mitsuhiro Fukata, Fumihiko Ishikawa, Yuho Najima, Takuji Yamauchi, Yoriko Saito, Katsuto Takenaka, Kohta Miyawaki, Hideki Shimazu, Kazuya Shimoda, Takaaki Kanemaru, Kei-Ichiro Nakamura, Keita Odashiro, Koji Nagafuji, Mine Harada, Koichi Akashi   +14 more
doaj   +1 more source

Bone marrow mononuclear cells and acute myocardial infarction [PDF]

, 2012
PMCID: PMC3340546This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided ...
Arnous, S, Martin, J, Mathur, A, Mozid, A   +3 more
core   +1 more source

Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes

Particle and Fibre Toxicology, 2020
Background Silica nanoparticles (nanoSiO 2 ) are promising systems that can deliver biologically active compounds to tissues such as the heart in a controllable manner.
O. Lozano, C. Silva-Platas, Héctor Chapoy-Villanueva, Baruc E. Pérez, J. Lees, C. Ramachandra, F. Contreras‐Torres, Anay Lázaro-Alfaro, Estefanía Luna-Figueroa, Judith Bernal-Ramírez, Aldemar Gordillo-Galeano, A. Benitez, Y. Oropeza-Almazán, E. C. Castillo, P. Koh, D. Hausenloy, Shiang Y. Lim, G. García-Rivas   +17 more
semanticscholar   +1 more source

Stimulation of Cardiomyocyte Proliferation Is Dependent on Species and Level of Maturation

Frontiers in Cell and Developmental Biology, 2022
The heart is one of the least regenerative organs. This is in large part due to the inability of adult mammalian cardiomyocytes to proliferate and divide.
Dogacan Yücel, Dogacan Yücel, Bayardo I. Garay, Bayardo I. Garay, Bayardo I. Garay, Rita C. R. Perlingeiro, Rita C. R. Perlingeiro, Rita C. R. Perlingeiro, Rita C. R. Perlingeiro, Jop H. van Berlo, Jop H. van Berlo, Jop H. van Berlo   +11 more
doaj   +1 more source